Morales TV, Saldaña C, Díaz MM

Language: Spanish
References: 16
Page: 129-134
PDF size: 206.91 Kb.

ABSTRACT

The increase in the intracellular calcium (Ca²⁺i) is a signal that regulates several cellular processes such as muscle contraction, morphogenesis, growth, apoptosis, gene expression, metabolism, secretion, fertilization, among others. To attain these responses, the intracellular calcium concentration ([Ca²⁺]i) is finely regulated by ion channels, ion pumps and Ca²⁺ binding proteins located in diverse compartments. Two organelles that function as Ca²⁺ sources are the endoplasmic reticulum and Golgi apparatus. Mitochondria capture and release Ca²⁺ transiently under physiological conditions to regulate ATP production. Recently, cell nucleus has become the focus of intense research because nucleus appears to be more complex than previously thought, for instance, nuclear membranes present different proteins involved in Ca²⁺ mobilization. It is now clear that changes in nuclear Ca²⁺ regulate numerous processes such as gene expression, alternative RNA splicing, nuclear envelope modification and molecular bidirectional traffic. We have now the tools and the experimental approaches to start unraveling the complexities of nuclear events.

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