2012, Number 5
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Med Int Mex 2012; 28 (5)
Rating Satisfaction Levothyroxine Sodium tri Slotted in Hypothyroid Patients
Fanghänel G, Sánchez-Reyes L, Escalante HA, Rangel RI, Torres P, Violante R, Madero FCM
Language: Spanish
References: 41
Page: 446-453
PDF size: 250.62 Kb.
ABSTRACT
Objective: This study was to identify in primary hypothyroid patients, the correct dose, both initial and maintenance and assess satisfaction
to the treatment, efficacy and safety of levothyroxine sodium trigroove.
Methods: It was a multicenter, prospective, open, non-comparative and longitudinal study. Patients of both sexes, between 18 and 75
years of age, were included. It was administered levotiroxina at 1.6 mcg/kg of weight, regardless of the dose and drug previously administered.
Was applied to evaluate the clinical using the Zulewski’s scale. In addition, it was applied a questionnaire for the evaluation of
satisfaction with the treatment.
Results: 85 patients from six participating centers at national level were included. According to the initial clinical assessment, the clinical
diagnosis index of hypothyroidism proposed by Zulewski and the thyroid profile demonstrated that 62 (61%) were not in appropriate clinical
and/or chemical control: 54 by hypofunction and 8 due to a overdosage were changed to levotiroxine trigroove and the dose was adjusted.
Significant differences were observed in the inferential analysis related to the scale of Zulewski when comparing the values obtained in the
basal measurement (3.94 ± 3.94) vs the final visit (1.69 ± 1.56) p ‹ 0.05. With regard to the levels of TSH, it was observed a significant
difference by comparing basal values (2.68 ± 5.76) with respect to the values of the final visit (1.65 ± 2.5) p ‹ 0.05. Of the total number
of patients, 65.5% at the end of the study ended with a dose of levothyroxine which is usually not prescribed. In the three parameters
assessed by the doctor (efficacy, safety and accuracy of dosage) an “excellent” evaluation prevailed.
Conclusions: According to our results, identifying the correct dose per kilogram of weight, both initial and maintenance in hypothyroid
patients and assess the satisfaction to the treatment, efficacy and safety and that the individualization of the therapeutic, allowed to obtain
an excellent result of effectiveness of 98.8%.
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Cárdenas-Ibarra L, et al. Cross-sectional observations of thyroid function in geriatric Mexican outpatients with and without dementia. Archive Gerontol Geriatr 2007;doi:10.1016/j. archger.2007.03.009.
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Zulewski H, Muller B, Exer P, Miserez AR, Staub JJ. Estimation of tissue hypothyroidism by a new clinical score: evaluation of patients with various grades of hypothyroidism and controls. J Clin Endocrinol Metab 1997;82:771-776.
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