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2012, Number 4

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AMC 2012; 16 (4)

Plasmapheresis by membrane filtration method for Guillain-Barré syndrome

Curbelo RL, Pila PR

Language: Spanish
References: 22
Page: 431-442
PDF size: 215.89 Kb.


ABSTRACT

Background: plasmapheresis by membrane filtration method is an effective treatment for patients with serious Guillain-Barré syndrome.
Objective: to demonstrate the advantages of plasmapheresis by membrane filtration in the treatment of severe Guillain-Barré syndrome.
Methods: a prospective and descriptive study was conducted in the intensive care unit at the Provincial Hospital Manuel Ascunce Domenech, Camaguey; from January 2007 to January 2011. The sample was composed of 23 patients with diagnosis of Guillain-Barré syndrome with respiratory paralysis. For plasmapheresis was used a conventional haemodialysis machine Fressenius 4008-D, and plasma filters and blood lines for haemodialysis. Extracted plasma volumes were about 3000 ml, as replacement solutions albumin human and fresh plasma were used. The information was collected in forms from clinical histories, relative frequencies and percentages of variables were processed.
Results: the recovery of muscle strength was significant and the quick exit of the ventilation of patients after the first five sessions. Few complications were presented. The treatment was effective for 95, 65 % of patients.
Conclusions: the treatment was effective; improvement was obtained after five exchange transfusions; the needed time to obtain the desired plasma volume was on an hour and a half to two hours and a half, quicker than the centrifugation method. It reduced the time of recovery of muscle strength and mechanical ventilation, turned out to be, in addition, a safe and quick technique for patients who suffer from this disease.


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