Manuel L, Zárate A, Hernández-Valencia M

Language: Spanish
References: 17
Page: 154-157
PDF size: 391.48 Kb.

ABSTRACT

Leptin is secreted by the fat tissue in order to establish the regulation of appetite at the brain site. Experimentally, it has been demonstrated that the absence of leptin synthesis or its cell receptor induces hyperfagia, obesity and diabetes. Clinical studies have been directed at the effect of leptin on obesity and diabetes.

REFERENCES

1. Coleman DL. Effects of parabiosis of obese with diabetes and normal mice. Diabetologia 1973; 9: 294-298.

2. Coleman DL. Obese and diabetes: Two mutant genes causing diabetes-obesity syndrome in mice. Diabetologia 1978; 14: 141-148.

3. Coleman DL. A historical perspective on leptin. Nature Medicine 2010; 16: 1097-1099.

4. Isse N, Ogawa Y, Tamura N, Masuzaki H, Mori K, Okazaki T et al. Structural organization and chromosomal assignment of the human obese gene. J Biol Chem 1995; 270: 27728-27733.

5. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of mouse obese gene and its human homologue. Nature 1994; 372: 425-431.

6. Maadej T, Boguski MS, Bryant SH. Threading analysis suggests that the obese gene product may be a helical cytokine. FEBS Lett 1995; 373: 13-18.

7. Zárate A, Saucedo R, Basurto L. El tejido adiposo: una nueva glándula del sistema endocrino. Ciencia 2007: 69-76.

8. Tartaglia L, Dembski M, Weng X, Deng N, Culpepper J, Devos R et al. Identification and expression cloning of a leptin receptor. Cell 1995; 83: 1263-1271.

9. Tartaglia LA. The leptin receptor. J Biol Chem 1997; 272: 6093-6096.

10. Flier JS, Maratos-Flier E. Obesity and the hypothalamus: novel peptides for new pathways. Cell 1998; 92: 437-440.

11. Trayhurn P, Hoggard N, Mercer JG, Rayner DV. Leptin: fundamental aspects. Int J Obesity 1999; 23(Suppl 1): 22-28.

12. Oppert JM. Leptine et régulation du poids corporel. Cah Nutr Diet 1997; 32: 217-223.

13. Lusting R. Childhood obesity: behavioral aberration or biochemical drive? Reinterpreting the First law of thermodynamics. Nature 2006; 2(8): 447-458.

14. Ahima RS, Osei SY. Editorial: Leptin and appetite control in lipodystrophy. J Clin Endocrinol Metabol 2004; 89: 4254-4257.

15. Manuel-Apolinar L, Zárate A, Rocha L, Hernández M. Fetal malnutrition affects hypothalamic leptin receptor expression after birth in male mice. Arch Med Res 2010; 41(4): 240-245.

16. The Lasker Foundation celebrates medical advances made with help from model organisms. Dis Model Mech 2009; 2(11-12): 532-533.

17. Golstein JL. How to win a Lasker? Take a close look at bathers and bulls. Nat Med 2010; 16(10): 1091-1096.