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2011, Number 4

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Rev Mex Med Repro 2011; 3.4 (4)

Characteristics optimizing the selection of oocytes donors

Guadarrama GLF, Trejo CH, Chinolla AZL, Pedraza CJ, Caldiño SF, Cubillos GS, Cuneo PS

Language: Spanish
References: 13
Page: 176-181
PDF size: 78.25 Kb.


ABSTRACT

Background: Oocyte donation is an assisted reproduction technique in which female gamete is aported by a different woman to that will receive this or the resulting embryo.
Objective: To identify the variables defining the profile of good reponse in oocyte donors.
Material and methods: A retrospective, longitudinal, descriptive study was done of the first cycle of controlled ovarian hyperstimulation of 53 donors for IVF-TE from November 2004 to March 2010. The characteristics of donors who achieved pregnancy in their first cycle were analyzed (n = 19).
Results: According to the group of nuligest or with previous pregnancy a significant difference was observed favoring donors with at least one term-pregnancy in the value of estradiol with hCG, number of mature follicles, total of captured and in metaphse II oocytes, without observing difference in the total dose of gonadotrophins nor in the basal hormonal profile.
Conclusions: Characteristics optimizing oocytes donations in a donor are a younger age than 25 years, a BMI lesser than 24.9 and tested fertility, thus, at the moment of selection of possible candidates for ovodonation these conditions should be looked for in order to obtain good rates of pregnancy and to use lower doses of gonadotrophin with the lesser probability of complications for the donor.


REFERENCES

  1. Remohí J, Simón C, Pellicer A. Reproducción humana. Madrid: McGraw-Hill Interamericana; 1996;348-359.

  2. Guidelines for oocyte donation. The American Society for Reproductive Medicine. Fertil Steril 2002;77(5):S6-S8.

  3. Soderstrom-Anttila V. Pregnancy and child outcome alter oocyte donation. Hum Reprod Update 2001;7:28-32.

  4. Stolwijk A, Zielhuis G, Sauer M, Hamilton CJ, Paulson RJ. The impact of the woman’ age on the success of standard and donor in vitro fertilization. Fertil Steril 1997;67:702-710.

  5. Gougeon A. Dynamics of follicular growth in the human: a model from preliminary results. Hum Reprod 1986;1:81-87.

  6. Brzyski R, Muasher S, Droesch K, Simonetti S, et al. Follicular atresia associated with concurrent initiation of gonadotropin releasing hormone agonist and folliclestimulating hormone for oocytes recruitment. Fertil Steril 1988;50:917-921.

  7. Tomas C, Nuojua-Huttunen S, Martikainen H. Pretreatment transvaginal ultrasound examination predicts ovarian responsiveness to gonadotrophins in in-vitro fertilization. Hum Reprod 1997;12:220-223.

  8. Obeso I, Galache P, Sepúlveda J, Díaz P, Patrizi P. The impact of body mass index on ovarian stimulation in young oocyte donors. Fertil Steril 2009;92(3, Suppl 1):S103.

  9. Mack CK, Pascal C, Gupta N, Cekleniak NA, et al. In search of the perfect donor: age and BMI influences in egg donors. Fertil Steril 2006;86(3 Suppl 1):S410.

  10. Bush CJ, Beltsos AN, Sasada KL, Martin-Johnston MK, et al. Clinical response of successful donor oocyte cycles. Fertil Steril 2007;88:S141-S142.

  11. Faber BM, Mercan R, Hamacher P, Muasher SJ, Taner JP. The impact of an egg donor’s age and her prior fertility on recipient pregnancy outcome. Fertil Steril 1997;68:370-372.

  12. Flisser E, Kump LM, Krey LC, Licciardi F. Donor age does not impact the success of oocyte donation cycles. Fertil Steril 2006;86:S211

  13. Fiszbajn K, Maero R, Lipowicz S, et al, Searching for the ideal donor in an oocyte donation program. Fertil Steril 2004;82(Suppl 2):S144.




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