Hinojosa CJC, Ramos GRA, Vital RVS

Language: Spanish
References: 20
Page: 63-68
PDF size: 78.99 Kb.

ABSTRACT

Aromatase inhibitors (AI) are compounds that diminish estrogen biosynthesis through reversible inhibition of aromatase enzymatic complex. The first generation of AI was developed in 1960, and the indications for their use had been adjusted in time thanks to improvement on their efficiency and less toxicity of the third generation ones. Nowadays, the main indication for their use is as adjuvant therapy in positive estrogen receptors breast cancer mainly in postmenopausal women. Other indications such as ovulation induction in patients with OMS II anovulation, controlled ovarian hyperstimulation in patients going to assisted reproduction techniques and medical treatment of selected cases of myomatosis and endometriosis, promise to extend their use in human reproductive medicine.

REFERENCES

1. Briest S, Stereans V. Adjuvant aromatase inhibitors and emerging quality of life considerations. Expert Rev Anticancer Ther 2008;8(1):1-4.

2. Czakja I, Simpson E. Aromatase research and its clinical significance. Pol J Endocrinol 2010;61(1):126-134.

3. Santen R, Brodie H, Simpson E, Siteri P, Brodie A. History of aromatase: saga of an important biological mediator and therapeutic target. Endocr Rev 2009;30(4):343-375.

4. Bueso L, Gago F, López R, Rodríguez N, Vigo S. Lineamientos para el tratamiento del cáncer de mama hormonodependiente. Rev Esp Med Quir 2005;10(1):16-18.

5. Perez E. Safety of aromatase inhibitors in the adjuvant setting. Breast Cancer Res Treat 2007;105:75-89.

6. Buzdar AU, Robertson JF, Eirmann W. An overview of the pharmacology and pharmacokinetics of the newer generation aromatase inhibitors anastrozole, lestrozole, and exemastane. Cancer 2002;95:2006-2016.

7. Briest S, Steran M. Adjuvant aromatase inhibitors and emerging quality of life considerations. Expert Rev Anticancer Ther 2008;8(1):1-4.

8. Pachón J, Posada N. Panorama actual de los inhibidores de la aromatasa en la inducción de la ovulación. Revista Colombiana de Obstetricia y Ginecología 2007;58(2):136-141.

9. ACOG. Committee Opinion. Aromatase inhibitors in gynecologyc practice. Obstet Gynecol 2008;112(2);405-407.

10. Polyzos N, Tsappi M, Mauri D, Atay V, et al. Aromatase inhibitors for infertility in polycystic ovary syndrome. The beginning or the end of a new era? Fertil Steril 2008;89:278-280.

11. Badaway A, Abdel B, Abulatta B. Clomiphene citrate or letrozole for ovulation induction in women with polycystic ovarian syndrome: a prospective randomized trial. Fertil Steril 2009;92(3):849-852.

12. Holzer H, Casper R, Tulandi T. A new era in ovulation induction. Fertil Steril 2006;85:277-284.

13. Parzamezhad M, Azmoon M, Alborzi S, Rajaeefard A, et al. A randomized, controlled clinical trial comparing the effects of aromatase inhibitor (letrozole) and gonadotropin releasing hormone agonist (triptorelin) of uterine leiomyioma volume and hormonal status. Fertil Steril 2010;93:193-198.

14. Hilario S, Bozzini N, Barracat E. Action of aromatase inhibitor for treatment of uterine leomyoma in menopausal patients. Fertil Steril 2009;91(1):240-243.

15. Hilario S, Bozzini N, Barracat E. Action of aromatase inhibitor for treatment of uterine leomyoma in menopausal patients. Fertil Steril 2009;91(1):240-243.

16. Altar E, Bulum S. Aromatase inhibitors: the next generation of therapeutics for endometriosis? Fertil Steril 2006;85:1317-1318.

17. ACOG. Committee Opinion. Aromatase inhibitors in gynecologic practice. Obstet Gynecol 2008;112(2);405-407.

18. Maia H, Casoy J, Valente J. Is aromatase expression in the endometrium the cause of endometriosis of related infertility? Gynecol Endocrinol 2009;25(4):253-257.

19. Bilotas M, Meresman G, Stella I, Sueldo C, Barañao R. El tratamiento con inhibidores de aromatasa reduce el tamaño de las lesiones en un modelo de endometriosis murina. Revista SAMER 2006;27-36.

20. Ferrrero S, Biscaldi E, Ventrinni P, Remorgida V. Aromatase inhibitors in the treatment of bladder endometriosis. Gynecol Endocrinol 2010;early online: 1-4.