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2011, Number 3

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Rev Hematol Mex 2011; 12 (3)

Meningeal infiltration in promyeolocytic leukemia. A report of four cases

de León-Cantú RE, Carrizales-Villarreal JACeballos-López AA, Gómez-Almaguer D

Language: Spanish
References: 21
Page: 140-143
PDF size: 72.71 Kb.


ABSTRACT

Acute promyelocytic leukemia (APL) is distinguished from other myeloblastic leukemias in biology, clinical behavior, prognosis and treatment. Three risk groups are recognized. The frequency of infiltration into central nervous system (CNS) is low. We present a series of 4 cases LAP with CNS relapse. Three adults and one child. Two patients were of high risk, one intermediate risk and other had a low risk. All were treated with all-trans retinoic acid (ATRA) and anthracyclines as induction therapy, and consolidation was continued according to risk. In one patient we used arsenic trioxide and autologous transplantation after relapse. A review of the literature is presented and we concluded that in patients at high risk , prophylaxis of meningeal leukemia should be administered.


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