García-Rodríguez F, Rodríguez-Romo LN, Gómez-Peña Á, Martínez-González O, Martínez-Cabriales SA, González-Llano Ó, Jaime PJC, Mancías-Guerra C, Gómez-Almaguer D

Language: Spanish
References: 25
Page: 136-140
PDF size: 58.85 Kb.

ABSTRACT

Background: The frequency of hereditary anemia in northeast of Mexico has not been studied, trying to reach that goal, at least partially, we analyze the osmotic fragility (OF) and hemoglobin electrophoresis (EHb) results reported by our laboratory, in order to identify how many patients with hemoglobinopathies and hereditary spherocytosis were detected in the last 5 years.
Methods: We analyzed the EHb results between June/2004 and January/2010, and OF results between January/2003 and January/2010 reported by the Laboratory of Hematology Service at the University Hospital Dr. José E. Gonzalez in Monterrey, México.
Results: We evaluated 243 EHb reports from 225 patients, 134 (59.6%) were abnormal: 96 (42.6%) thalassemias, 28 (12.4%) HbS presence, 6 (2.7%) thalassemia/HbS, 3 (1.3%) hereditary persistence of HbF and 1 (0.4%) HbC presence. We analyzed 208 OF results from 201 patients, 96 (47.8%) reports were positives, with a median age of 16 (0 - 77) years, 91 (45.3%) were female and 110 (54.7%) male.
Conclusion: The request of this tests in only above 200 patients over more than five years show the low incidence of these diseases in the region; on the other hand, hemoglobinopathies were diagnosed in just 134 cases, being β-thalassemia the most frequently disease reported. Our data suggests that hereditary spherocytosis is the most common hemolytic anemia in the northeast of Mexico.

REFERENCES

1. Villalpando S, Shamah-Levy T, Ramirez-Silva CI, Mejia- Rodriguez F, Rivera JA. Prevalence of anemia in children 1 to 12 years of age. Results from a nationwide probabilistic survey in Mexico. Salud Publica Mex 2003;45 (Suppl 4):S490-498.

2. Villalpando S, Shamah-Levy T, Garcia-Guerra A, Mundo-Rosas V, et al. The prevalence of anemia decreased in Mexican preschool and school-age children from 1999 to 2006. Salud Publica Mex 2009;51(Suppl 4):S507-514.

3. Mendez Estrada RO, Pacheco B, Noriega Verdugo H, Quihui L, Morales G, Valencia ME. [Prevalence of iron deficiency and iron deficiency anemia in pregnant adolescents from northwest Mexico, 2007-2008]. Arch Latinoam Nutr 2009;59(2):147-151.

4. Duque X, Flores-Hernandez S, Flores-Huerta S, Mendez- Ramirez I, et al. Prevalence of anemia and deficiency of iron, folic acid, and zinc in children younger than 2 years of age who use the health services provided by the Mexican Social Security Institute. BMC Public Health 2007;7:345.

5. Clarke GM, Higgins TN. Laboratory investigation of hemoglobinopathies and thalassemias: review and update. Clin Chem 2000;46(8 Pt 2):1284-1290.

6. Hardison RC, Chui DH, Giardine B, Riemer C, et al. HbVar: A relational database of human hemoglobin variants and thalassemia mutations at the globin gene server. Hum Mutat 2002;19(3):225-233.

7. Patrinos GP, Giardine B, Riemer C, Miller W, et al. Improvements in the HbVar database of human hemoglobin variants and thalassemia mutations for population and sequence variation studies. Nucleic Acids Res 2004;32(Database issue):D537-41.

8. Cai R, Liu J, Wang L, Liang X, et al. Study on molecular epidemiology of the alpha-thalassemias in Liuzhou City, Guangxi Autonomous Region, China. Hemoglobin 2004;28(4):325-333.

9. Higgs DR, Vickers MA, Wilkie AO, Pretorius IM, et al. A review of the molecular genetics of the human alpha-globin gene cluster. Blood 1989;73(5):1081-1104.

10. Chong SS, Boehm CD, Cutting GR, Higgs DR. Simplified multiplex-PCR diagnosis of common southeast asian deletional determinants of alpha-thalassemia. Clin Chem 2000;46(10):1692-1695.

11. Cao A, Galanello R. Beta-thalassemia. Genet Med 2010;12(2):61-76.

12. Angastiniotis M, Modell B. Global epidemiology of hemoglobin disorders. Ann N Y Acad Sci 1998;850:251-269.

13. Weatherall DJ, Clegg JB. Inherited haemoglobin disorders: an increasing global health problem. Bull World Health Organ 2001;79(8):704-712.

14. Giordano PC, Harteveld CL, Heister AJ, Batelaan D, et al. The molecular spectrum of beta-thalassemia and abnormal hemoglobins in the allochthonous and autochthonous dutch population. Community Genet 1998;1(4):243-251.

15. Hickman M, Modell B, Greengross P, Chapman C, et al. Mapping the prevalence of sickle cell and beta thalassaemia in England: estimating and validating ethnic-specific rates. Br J Haematol 1999;104(4):860-867.

16. Ashtiani MT, Monajemzadeh M, Sina AH, Berenji F, et al. Prevalence of haemoglobinopathies in 34,030 healthy adults in Tehran, Iran. J Clin Pathol 2009;62(10):924-925.

17. Casas-Castaneda M, Hernandez-Lugo I, Torres O, Barajas H, et al. Alpha-thalassemia in a selected population of Mexico. Rev Invest Clin 1998;50(5):395-398.

18. Ibarra B, Vaca G, Franco-Gamboa E, Garcia-Cruz D, et al. Abnormal hemoglobins in Northwestern Mexico. Acta Anthropogenet 1982;6(4):217-223.

19. Ruiz-Arguelles GJ, Lopez-Martinez B, Ruiz-Reyes G. Heterozygous beta-thalassemia: not infrequent in Mexico. Arch Med Res 2001;32(4):293-295.

20. Cobian JG, Sanchez-Lopez JY, Magana MT, Chavez ML, et al. Types and frequencies of hemoglobin disorders in the pacific coast of four states of Mexico. Rev Invest Clin 2009;61(5):399-404.

21. Perrotta S, Gallagher PG, Mohandas N. Hereditary spherocytosis. Lancet 2008;372(9647):1411-1426.

22. Sanchez-Lopez JY, Camacho AL, Magana MT, Ibarra B, Perea FJ. Red cell membrane protein deficiencies in Mexican patients with hereditary spherocytosis. Blood Cells Mol Dis 2003;31(3):357-359.

23. Delaunay J. The molecular basis of hereditary red cell membrane disorders. Blood Rev 2007;21(1):1-20.

24. Lux SE, Tse WT, Menninger JC, John KM, et al. Hereditary spherocytosis associated with deletion of human erythrocyte ankyrin gene on chromosome 8. Nature 1990;345(6277):736-739.

25. Zayas-Perez P, Ruiz-Reyes G. Hemoglobinas anormales identificadas en una sola institución: experiencia de 22 años. Rev Hematol Mex 2010;11(2):75-77.