2010, Number 3
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Rev Hematol Mex 2010; 11 (3)
NK cells neoplasms: a report of fourteen cases studied in a single institution
Valdivia-Ferrufino D, Assis MA, Pérez-Romano B, Fragoso-Flores J, Ruiz-Argüelles A
Language: Spanish
References: 30
Page: 129-135
PDF size: 92.96 Kb.
ABSTRACT
Background: NK cells are large lymphocytes with abundant cytoplasmic granules, that bear the CD3-, CD16/56+ phenotype. NK lineage tumors stem from either NK precursors or from mature NK cells. An interim classification into 6 tumor types was proposed at the third meeting of the NK cell tumor study group (NKSG), held in Japan in 2000. Each of the 6 types exhibits different clinical features.
Material and Methods: Fourteen cases of NK cell tumors were found amongst 8467 leukemia cases studied at Laboratorios Clínicos de Puebla from january 1997 to march 2010. A cytomorphologic study of the sample was performed in each case, and the immunologic classification was made according to the guidelines from the Latin American Consensus Conferences for Flow Cytometric Immunophenotyping of Hematological Malignancies.
Results and Discussion: The types of NK neoplasia analyzed in this study were rather heterogeneous. According to the NKSG classification, four cases corresponded to NK precursor/myeloid leukemia, three cases were classified as NK precursor acute leukemia, and three more were chronic NK cell lymphocytosis; the remaining cases were two blastic NK cell leukemia, and two aggressive NK cell lymphoma/leukemia. Inasmuch as the complete clinical records of some of the cases were not available, the NKSG classification criteria were not fulfilled in all instances; however, the antigenic profiles of the neoplastic cells were consonant with those considered in this classification.
REFERENCES
Cocom-Góngora PC, Mut-Martín MC, García-Miss MR. Los receptores de los linfocitos de la inmunidad innata. Rev Biomed 2004;15:113-122.
Oshimi K. Leukemia and lymphoma of natural killer lineage cells. International Journal of Hematology 2003;78:18-23.
Shibuya A. Development and functions of natural killer cells. Int Journal of Hematology 2003;78:1-6.
Shibuya A, Nagayoshi K, Nokamura K, Nakauchi H. Lymphokine requirement of the generation of natural killer cells from CD34+ hematopoietic progenitor cells. Blood 1995;85(15):3538-3546.
Silva MRG, Hoffman R, Srour EF, Ascensao JL. Generation of human natural killer cells from immature progenitors does not require marrow stromal cells. Blood 1994;84(3):841-846.
Mrózek E, Anderson P, Caligiuri MA. Role of interleukin 15 in the development of human CD56+ natural killer cells from CD34+ hematopoietic progenitor cells. Blood 1996;87(7):2632-2640.
Yu H, Fehniger TA, Fuchsuber P, Thiel KS, et al. Flt3 ligand promotes the generation of a distinct CD34+ human natural killer cell progenitor that responds to Interleukin-15. Blood 1998; 92(10):3647-3657.
Fauriat C, Marcenaro E, Sivori S, Rey J, et al. Natural killer cell-triggering receptors in patients with acute leukemia. Leuk Lymphoma 2003;44(10):1683-1689.
Long E, Wagtmann N. Natural killer cell receptors. Curr Opin Inmunol 1997;9:344-350.
Lannier LL, Corliss BC, Wu J, Leong C, Phillips J. Immunoreceptor DP-12 bearing a tyrosine-based activation motif is involved in activating NK cells. Nature 1998;391:703-707.
Lannier LL. Natural killer cell receptor signaling. Curr Opin Immunol 2003;15:308-313.
Seaman WE. Natural killer and natural killer T cells. Arthritis Rheum 2000;43:1204-1217.
Moretta A, Bottino C, Vitale M, Pende D, et al. Receptors for HLA Class-I molecules in human natural killer cells. Annu Rev Immunol 1996;14:619-628.
Colonna M. Unmasking the killer’s accomplice. Nature 1998;391:642-643.
Rajagopalan S, Long E. A human histocompatibility leukocyte antigen (HLA) G-specific receptor expressed on all natural killer cells. J Exp Med 1999;189:1093-1099.
Suzuki R, Nakamura S. Malignancies of natural killer (NK) precursor: myeloid/NK cell precursor acute leukemia and blastic NK cell Lymphoma/Leukemia. Leuk Res 1999;23(7):615-624.
Murashige N, Kami M, Kishi Y, Kim SW, et al. Allogeneic haematopoietic stem cell transplantation as a promising treatment for natural killer-cell neoplasms. Br J Haematol 2005; 130(4):561-567.
Harris NL, Jaffe E. A revised European American Classification of Lymphoid Neoplasm: a proposal from International Study Group. Blood 1994;84:161-192.
Harris NL. The Revised European American Lymphoma Classification. Trends in Onco-Hematology 1996;4(3).
Sanz-Sabrafen J. Hematología clínica. 2ª ed. Barcelona: Doyma,1988;p:375.
Ruiz Argüelles A, Duque E, Orfao A. Report on the First Latin American Consensus Conference for Flow Citometry Immunophenotyping of Leukemia. Citometry 1988;34:39-42.
Ruiz-Argüelles A, Rivadeneyra-Espinoza L, Duque RE, Orfao A. Report on the second Latin American consensus conference for flow cytometric immunophenotyping of hematological malignancies. Cytometry 2005;708:39-44.
Valmary S, Danjoux M, Delsol G, Brousset P. Diagnostic value of anti-terminal deoxynucleotidyl transferase antibody (TdT) in hematologic pathology. Ann Pathol 2005;25(1): 25-32.
Petrella T, Bagot M, Willemze R, Beylot-Barry M, et al. Blastic NK-cell lymphomas (agranular CD4+CD56+ hematodermic neoplasms): A review. Am J Clin Pathol 2005;123(5):662-675.
Herling M, Teitell MA, Shen RR, Medeiros LJ, Jones D. TCL1 expression in plasmocytoid dendritic cells (DC2s) and the related CD4+ CD56+ blastic tumors of skin. Blood 2003;101(12): 5007-5009.
Pombo de Oliveira MS, Bossa YE, Alencar DM, Curvello C, et al. Acute leukemia with natural killer cells antigens in Brazilian children. Leuk Lymphoma 2004;45(4):739-743.
Ghobrial IM, Weenig RH, Pittlekow MR, Qu G, et al. Clinical outcome of patients with subcutaneous panniculitis-like T-cell lymphoma. Leuk Lymphoma 2005;46(5):703-708.
Wei SZ, Liu TH, Wang DT, Cao JL, et al. Hepatosplenic gamma delta T-cell lymphoma. World J Gastroenterol 2005;11(24):3729-3734.
Lee MY, Tsou MH, Tan TD, Lu MC. Clinicopathological analysis of T-cell lymphoma in Taiwan according to WHO classification: high incidence of enteropathy-type intestinal T-cell lymphoma. Eur J Haematol 2005;75(3):221-226.
Hodges E, Williams AP, Harris S, Smith JL. T-cell receptor molecular diagnosis of T cell lymphoma. Methods Mol Med 2005;115:197-215.
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