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2010, Number 2

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Rev Hematol Mex 2010; 11 (2)

Treatment of adult immune thrombocytopenic purpura

Flores LA, Orna ME

Language: Spanish
References: 22
Page: 95-100
PDF size: 72.54 Kb.


ABSTRACT

There is not any absolutely effective and unique treatment for immune thrombocytopenic purpura (ITP) in adults. Most of the patients never need it, others respond well, and some are resistant to almost all therapies. Steroids are effective in most cases, while IV immunoglobulin enables immediate responses. During 50 years splenectomy was the only alternative treatment, and remains the most effective therapeutic method. The remaining therapies are less effective or are under study. This is the case of the monoclonal antibody anti-CD20 (rituximab) and the thrombopoietin analogues. Pregnancy and childbirth are the most delicate situations to control ITP. Many drugs can not be used during this period, with IV immunoglobulin and, to a lesser extent, prednisone, being the more useful therapy.


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