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2011, Number 1

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Rev Educ Bioquimica 2011; 30 (1)

Tolerancia a la glucosa en personas mayores de 60 años

Garcia SJJ, Serrano GLB, Recio VR, Calderón SJV

Language: Spanish
References: 37
Page: 3-11
PDF size: 348.41 Kb.


ABSTRACT

Age increasing in people is frequently associated with carbohydrate intolerance, insulin resistance, metabolic syndrome, prediabetes and diabetes. It almost seems that these metabolic disturbances are inevitable with age increasing. By the other hand, standard diagnostic tests are frequently misunderstood by making comparisons with younger people increasing the possibility of a wrong diagnostic and a wrong label to 60 year old patients that can take them even to hypoglycemic states. In the present work, changes in metabolism related to changes on carbohydrate metabolism in elderly are analyzed, the consequences, the ways to compensate this changes and the relationship with glucose intolerance and insulin resistance. Also, the results of glucose tolerance test curves in patients of ages from 60 to 70, 70 to 80 and 80 and older are presented, analyzing changes by decades, emphasizing the importance and necessity of an individual evaluation, using standards according to age and keeping in mind the process of elderly and metabolic changes that comes with it.


REFERENCES

  1. OMS. Segunda Asamblea Mundial sobre el Envejecimiento. Madrid España del 18- 12 de Abril, 2002.http://inmayores.mides.gub.uy/innovaportal/file/1625/1/Plan%20Internacional%20de%20Madrid%20sobre%20Envejecimiento%2C%202002.pdf.

  2. Ham Ch R (1993) México: País en proceso de envejecimiento. Comercio Exterior México 3(7):688-696.

  3. SSA (2007) Dirección General de Estadística e Informática. Mortalidad. Información Técnica. México.http://www.inegi.gob.mx/inegi/contenidos/espanol/prensa/contenidos/estadisticas/2007/cancer07.pdf.

  4. Hazzard WR, Blass JP, Ettinger WH, Halter JB, Ouslander J (1999) Principles of Geriatric Medicine and Gerontology. Fourth Edition. McGraw Hill. New York pp. 876.

  5. Halter JB. Carbohydrate Metabolism. En Handbook of Physiology Aging. Bethesda M.D. Am J Physiol Soc 1995, sect 11. Capt 7 pp 119-145.

  6. United Nations. Problems of the elderly and the aged Draft programmed and arrangements for the World Assembly on The Elderly Report The Secretary General. New York. U.N. 1980 Document A/35/130.

  7. Kevin K, Velkoff VA. American Ageing World (2001) International Population Reports. Issue. Nov, US. Department of Health and Human Services National Institute of Health, National Institute of Ageing.

  8. Halter JB (1995) Aging and carbohydrate metabolism. Handbook of Physiology. En Masoro E.J. Ed. New York. Oxford University Pres.

  9. International Diabetes Federation (2009) Diabetes Atlas at the 20th World Diabetes Congress in October 2009. Montreal, Canada. http://www.diabetesatlas.org/. Accessed february 2011.

  10. Kuri Morales P, Vargas Cortés M, Juárez Vergara P (2001) La Diabetes en México. Dirección General de Epidemiología SSA. Periodismo de Ciencia y Tecnología. Investigación y Desarrollo. México.

  11. IMSS Guía Diagnóstica Terapéutica. Diabetes Mellitus tipo 2. Rev. Med. IMSS. 2009; 313-336. http://www.imss.gob.mx/NR/rdonlyres/DEB03CD4-53C6-423C-8F89-1F5CF03C2188/0/GERDiabetesMellitusTipo2.pdf

  12. Andres R (1971) Aging and Diabetes. Med Clin North Am 55(4):835-86.

  13. Ham’s JB, Harris WC, Knowler WC, Bennett PH (1987) Prevalence of Diabetes and impaired glucose tolerance and plasma glucose levels in US Population. Diabetes 36:523-534.

  14. Saaristo T, Peltonmen M, Lindstrom S, Saariskoski L, Sundvall J, Eriksson JG, Tuomilehto J (2005) Cross sectional evaluation of the finish Diabetes Risk Score: a tool to identify undetected type 2 diabetes, abnormal glucose tolerance and metabolic syndrome. Diab Vasc Dis Res 2(2):67-72.

  15. Richard JL, Sultan A, Dauses JP, Vanneream D, Parer-Richard C (2002) Diagnosis of diabetes mellitus and intermediate glucose abnormalities in obese patients based on ADA (1997) and WHO (1985). Criteria Diab Med 19(4): 292-9.

  16. Decode Study Group (2003) Age and Sex specific prevalence of diabetes and impaired glucose regulation in European Cohorts 26(1):61-69.

  17. Kanaya AM, Wassel Fry CL, de Rekeneire N, Shorr RI, Scwartz AV, Goodpaster BH, Neuman AB, Harris T, Banet Connos E (2005) Predicting the development of diabetes in older adults: the derivation and validation of a prediction rule. Diabetes Care 28(2):404-408.

  18. Fuchigami M, Nakano H, Oba K, Metori B (1994) Oral glucose tolerance test using a continuous blood sampling technique for analysis of blood glucose curve. Nipon Ronen Igakki Zasshi 31(7): 518-24.

  19. Nozaki T (2001) Pancreatic b cell function and glucose in elderly subjects with glucose intolerance. Nippon Ika DaDaigaku Zassi 52(5): 223-227.

  20. Serrano R, Villar M, Gallardo N, Carrascosa JM, Martinez C, Andrés A (2009) The effect of aging on insulin signalling pathway is tissue dependent: central role of adipose tissue in the insulin resistance of aging. Mech Ageing Dev 130(3):189-97.

  21. Villar M, Serrano R, Gallardo N, Carrascosa JM, Martinez C, Andrés A (2006) Altered subcellular distribution of IRS-1 and IRS-3 is associated with defective Akt activation and GLUT4 translocation in insulin-resistant old rat adipocytes. Biochim Biophys Acta 1763(2):197-206.

  22. Semba RD, Beck J, Sun K, Egan JM, Carlson OD, Varadhan R, Ferrucci L (2010) Relationship of a dominant advanced glycation end product, serum carboxymethyl-lysine, and abnormal glucose metabolism in adults: The Baltimore longitudinal study of aging. The Journal of Nutrition, Health & Aging Vol 14 (7):507-13.

  23. Elhai D, Muller DC, Egan JM, Andres R, Veldhyvist J, Menelly GS (2002) Glucose tolerance, glucose utilization and insulin secretion in ageing. Norvartis Found Symp 222-224 discussion 246-9.

  24. Chen M, Bergman RN, Pacini G, Porte D Jr (1985) Pathogenesis of age related glucose intolerance in man: Insulin resistance and decreased beta cell function. J Clin Endocrinol Metab 60(1):13-20.

  25. Pacini G, Beccaro F, Valerio A (1996) Reduced b cell secretion and insulin hepatic extraction in healthy elderly subjects. J Am Geriatr Soc 38:1283.

  26. Bourney RE, Kahrt WM, Kirwan JP (1993) Relationship between glucose tolerance and glucose stimulated insulin response in 65 years olds. J Gerontol 48(4):122-127.

  27. Iozzo P. Becker-Nielsen H, Laakso M, Smith U. Yki-Järvinen H, Ferrannini E (1999) Independent influence of age basal on insulin secretion in non diabetic humans. J Clin Endocrionol Metab 84:863-868.

  28. Festa A, D´Agostino R Jr, Hanley AJG, Karter AJ, Saad MF, Haffner SM (2004) Differences in insulin Resistance in Non diabetic subjects with isolated impaired glucose tolerance or isolated impaired fasting glucose. Diabetes 53:1549-1555.

  29. Krishnan RK, Hernandez JM, Williamson DL (1998) Age related differences in the pancreatic ß cell response to hyperglycaemia after eccentric exercise AM J Physol: (EndocrinolMetab 38):E 463.

  30. Raeven G (2003) Age and glucose intolerance, effect of fitness and fatness. Diabetes Care 26(2):539-40.

  31. Baker LD, Frank LL, Foster-Schubert K, Green PS, Wilkinson CW, McTiernan A, Cholerton BA, Plymate SR, Fishel MA, Watson GS, Duncan GE, Mehta PD, Craft S (2010) Aerobic exercise improves cognition for older adults with glucose intolerance, a risk factor for Alzheimer’s disease. J Alzheimers Dis 22(2):569-79.

  32. Walton C, Godsland IF, Prouder AJ (1992) Evaluation of four mathematical models of glucose and insulin dynamics with analysis of effects of age and obesity. Am J Physiol (Endocrinol Metab 25):E 755.

  33. Van Pelt RE, Jankowski CM, Gozansky WS, Wolfe P, Schwartz RS, Kohrt WM (2011) Sex differences in the association of thigh fat and metabolic risk in older adults. Obesity 19, 422-428.

  34. Oba K, Nakano H, Okasaki K (1996) Mild glucose intolerance in the elderly. Nippn Rinsho 54(10): 2773-8.

  35. Creutzfeldt W (2005) The [pre-] history of the incretin concept. Regul Pept 128: 87–91.

  36. Basu R, Breda E, Oberg AL, Powell CC, Man Chiara D, Basu A, Vittone JL, Klee GG, Arora P, Jensen MD, Toffolo G, Cobelli C, Rizza RA (2003) Mechanisms of the Age-Associated Deterioration in Glucose Tolerance. Contribution of Alterations in Insulin Secretion, Action and Clearance. Diabetes 52, 52:1738–1748.

  37. Davidson MB (1979) The effect of aging on carbohydrate metabolism: a view of the English Literature and practical approach to the diagnosis of Diabetes Mellitus in the elderly. Metabolism 28: 688-705.




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