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2011, Number 2

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Rev Educ Bioquimica 2011; 30 (2)

El glutation y su asociación con las enfermedades neurodegenerativas, la esquizofrenia, el envejecimiento y la isquemia cerebral

Martínez-Sámano J, Torres-Durán PV, Juárez-Oropeza MA

Language: Spanish
References: 34
Page: 56-67
PDF size: 467.98 Kb.


ABSTRACT

Neurodegenerative diseases, schizophrenia, aging and brain ischemia are associated, at different stages of development, with the existence of oxidative stress. Antioxidants constitute an axis of protection against the production of reactive species; these include both enzyme and non-enzyme defenses. Glutathione, in its reduced form, is a non-enzyme defense, and is one of the first lines of defense against oxidative damage. The biological functions of glutathione involve its participation as: antioxidant, neuromodulator, detoxifying, so its deficiency is important in the pathogenesis of the diseases mentioned above, as at different stages of their development is a significant decrease in brain levels of this metabolite. Knowledge of the glutathione metabolism in the brain is necessary to understand the progression and even the development of diseases associated with neurodegeneration.


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