García-Gómez E, González-Pedrajo B

Language: Spanish
References: 30
Page: 45-55
PDF size: 499.46 Kb.

ABSTRACT

Gram-negative bacteria use diverse protein secretion systems for numerous aspects of their life cycle. During the assembly process these systems need to span the inner and outer membranes, the periplasmic space and the cell wall or peptidoglycan meshwork. In order to traverse the cell wall, secretion systems require specialized enzymes named transport lytic transglycosylases (LTs). LTs have been identified associated to several secretion systems and are proposed to make gaps in the peptidoglycan layer in a temporally and spatially controlled fashion, allowing the insertion of multiprotein complexes in the cell envelope.

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