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ISSN 0185-3252 (Print)
Revista de la Asociación Médica del Centro Médico ABC

2000, Number 2

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An Med Asoc Med Hosp ABC 2000; 45 (2)

Genetic markers associated with proliferative diabetic retinopathy in Mexicans with non insulin dependent diabetes mellitus

Anda-Turati M, Granados AJ, Quiroz MH

Language: Spanish
References: 12
Page: 61-64
PDF size: 98.19 Kb.


ABSTRACT

Diabetic proliferative retinopathy (DPR) is one the most important complications related to diabetes mellitus. There is a high prevalence for the development of diabetes mellitus in Mexican mestizos and for these reason, it is interesting to know if there can be any genetic susceptibility or resistance for the development of these kind of complications related to diabetes mellitus. The goal of this study is to identify the alleli of the genes of the major histocompatibility complex as proliferative diabetic retinopathy in Mexican patients with no insulin dependent diabetes mellitus (NIDDM). We included 50 patients who were genetically classified in class I and II in the major histocompatibility complex. The results were analyzed by the c2 and Fisher’s test. We found significant increments of HLA-B35 and HLA-B40 in all our patients. The antigens that can provide protection for the development of DPR are DR-9, DR-10, DR-5. The antigen related to susceptibility is DR-6. Nevertheless our group is very small, we found statistically significant results, which we consider important.


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