Martín-Viaña NP, García PCM, Bellma MA, Salomón S, González SML, Fusté MV, Agüero FS

Language: Spanish
References: 13
Page: 267-278
PDF size: 99.97 Kb.

ABSTRACT

Introduction: the natural raw materials as active pharmaceutical ingredients are increasingly spreading in the pharmaceutical industry to prepare drugs, cosmetic products and supplements. Noni (Morinda citrifolia L.) is a small evergreen tree that grows in the Hawaiian coastline and may be found in large 1 300-foot forests. The indigenous Hawaian population has used it for centuries. Traditional Polynesian healers used to employ all the Noni plant components such as flowers, bark, roots and particularly the fruit to treat health problems going from aphtae to rheumatism. The intestinal parasites, fevers and skin infections are some examples of the most common diseases that were treated with this Polynesian wonder.
Objective: to obtain juice from aqueous extract of dry Noni fruits as nutraceutic product for human use.
Methods: the technological development of the product was carried out along with the sensorial evaluation and the microbiological, toxicological and chemical-physical stability studies; it was stored in one-litre plastic containers at room temperature.
Results: the final amber solution had peculiar smell and taste and was tolerable to people; it mostly contained aqueous Noni extract and was innocuous and stable from the microbiological, chemical and physical viewpoints during the length of time and under the conditions set for the study.
Conclusions: the formulation of Noni juice coming in raspberry, lime, banana or vanilla flavours complied with the set quality standards of the manufacturer's technique and the National Institute of Food Hygiene approved it to be used by humans.

REFERENCES

1. Solomón N. El jugo de Noni la fruta tropical de los 101 usos medicinales. New York; 2002.

2. Mc Clacthey W. From polynesian healers to health food stores: changing perspectives of Morinda Citrifolia. Integr Cancer Ther. 2002;1(2):110-20.

3. Dixon AR, Mc Millen H, Erkin NL. Ferment this: the transformation of noni, a tradicional Polynesian medicine (Morinda citrifolia, Rubiaceae). Econ Bot. 1999;53:51- 68.

4. Wang MY, West BJ, Jensen CJ, Nowicki D, Su C, Palu AK, et al. Morinda citrifolia (Noni): a literature review and recent advances in Noni research. Acta Pharmacol Sin. 2002;23:1127-41.

5. Mueller BA, Scott MK, Sowinski KM, Prag KA. Noni juice (Morinda citrifolia): hidden potential for hyperkalemia? Am J Kydney Dis. 2000;35(2):310-2.

6. Carr ME, Klotz J, Bergeron M. Coumadin resistance and the vitamin supplement «Noni». Am J Hematol. 2004;77(1):103.

7. Milloning G, Stadlmann S, Vogel W. Herbal hepatotoxicity: acute hepatitis caused by a noni preparation (Morinda citrifolia). Eur J Gastroenterol Hepatol. 2005;17(4):445-7.

8. Stadlbauer V, Fickert P, Lackner C, Schmerlaib J, Krisper P, Trauner M, et al. Hepatotoxicity of noni juice: report of two cases. World J Gastroenterol. 2005;11(30):4758-60.

9. European Commission. 2002. Scientific Committee on Food. Opinion of the Scientific Committee on Food on Tahitian Noni Juice. SCF/CS/NF/DOS/18 ADD 2 Final. [cited Dec 11 2002]. Available from: http://europa.eu.int/comm/food/fs/sc/scf/out151_en.pdf

10. West BJ, Jense CJ, Westendorf J. Noni juice is not hepatotoxic. World J Gastroenterol. 2006;12(22):3616-19.

11. Newell GJ, Mc Farlane JD. Expanded tables for multiple comparison procederes in the analysis of ranked data. J Food Sci. 1987;526(6):1721-25.

12. USP 31-NF 26. Atributos Microbiológicos de Productos Farmacéuticos No Estériles. USP 31 Farmacopea de los Estados Unidos de América. NF 26 Formulario Nacional; 2008. p. 801.

13. OECD. Guideline for testing of chemical Acute Oral Toxicity Acute Toxic Class Method Nº 423 Adopted 20 December; 2001.