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2011, Number 4

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Rev Cubana Plant Med 2011; 16 (4)

Development of a technology for obtaining the Momordica charantia L. aqueous extract

Salomón IS, López HOD, González SML

Language: Spanish
References: 14
Page: 304-312
PDF size: 160.97 Kb.


ABSTRACT

Introduction: Momordica charantia L. aqueous extracts have scientifically-confirmed therapeutical potential, which makes it possible to use it in the treatment of several diseases, particulary diabetes. Obtaining a standardized extract is of great importance to reproduce it at industrial scale and also to obtain a pharmaceutically active ingredient (FAI) for the development of orally administered finished forms.
Objectives: to develop a technology at lab scale to obtain standardized aqueous extract from Momordica charantia L.
Methods: the study of the operational parameters (vegetal matter-solvent ration and extraction time) was performed in a lab reactor designed according to the dimensions of an industrial reactor, with a 3-level surface design of factorial response (3^2).
Results: the studied factors significantly influence the extraction process in which time is the most influential. There exists direct proportion between vegetal matter-solvent ration and the content of extracted solids, being the latter inversely proportionate to the extraction time. The highest content of extracted solids was reached with vegetal matter-solvent ratio of 1:25 and extraction time of 0.5 hours.
Conclusions: the operational conditions that support the highest solid extraction in obtaining the aqueous extract at the experimental phase were determined when the vegetal matter-solvent ratio and the extraction time were 1:25 and 0.5 hours respectively.


REFERENCES

  1. Shih CC, Lin CH, Lin WL, Wu JB. Momordica charantia extract on insulin resistance and the skeletal muscle GLUT4 protein in fructose-fed rats. J Ethnopharmacol. 2009;123(1):82-90.

  2. Roig JT. Plantas medicinales, aromáticas o venenosas de Cuba. La Habana: Ed. Científico Técnica, Instituto Cubano del Libro; 1974. p. 318-20.

  3. Villaseñor JL, Espinosa FJ. Catálogo de malezas de México. Universidad Nacional Autónoma de México. Consejo Nacional Consultivo Fitosanitario. México, D. F.: Fondo de Cultura Económica; 1998.

  4. Grover JK, Yadav SP. Pharmacological actions and potential uses of Momordica charantia: a review. J Ethnopharmacol. 2004;93(1):123-32.

  5. Nerurkar PV, Lee YK, Linden EH, Lim S, Pearson L, Frank J, et al. Lipid lowering effects of Momordica charantia (Bitter Melon) in HIV-1-protease inhibitor-treated human hepatoma cells, HepG2. Br J Pharmacol. 2006;148(8):1156-64.

  6. Basch E, Gabardi S, Ulbricht C. Bitter melon (Momordica charantia): a review of efficacy and safety. Am J Health Syst Pharm. 2003;60(4):356-9.

  7. Abascal K, Yarnell E. Using bitter melon to treat diabetes. Altern Complemen Ther. 2005;11(4):179-84.

  8. Dans AM, Villarruz MV, Jimeno CA, Javelosa MA, Chua J, Bautista R, et al. The effect of Momordica charantia capsule preparation on glycemic control in type 2 diabetes mellitus needs further studies. J Clin Epidemiol. 2007;60(6):554-9.

  9. Ahmed I, Adeghate E, Sharma AK, Pallot DJ, Singh J. Effects of Momordica charantia fruit juice on islet morphology in the pancreas of the streptozotocindiabetic rat. Diabetes Res Clin Pract. 1998;40(3):145-51.

  10. Ahmed I, Lakhani MS, Gillett M, John A, Raza H. Hypotriglyceridemic and hypocholesterolemic effects of anti-diabetic Momordica charantia (karela) fruit extract in streptozotocin-induced diabetic rats. Diabetes Res Clin Pract. 2001;51(3):155-61.

  11. Dans AM, Villarruz MV, Jimeno CA, Javelosa MA, Chua J, Bautista R, Velez GG. The effect of Momordica charantia capsule preparation on glycemic control in type 2 diabetes mellitus needs further studies. J Clin Epidemiol. 2007;60(6):554-9.

  12. Lagarto Alicia, Couret Micaela, Guerra Isbel, López Raisell. Toxicidad aguda oral y ensayos de irritación de extractos acuoso e hidroalcohólico de Momordica charantia L. Rev Cubana Plant Med [serie en Internet]. 2008[citado 19 Oct 2010];13(3). Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1028- 47962008000300005&lng=es

  13. Anmdrews M. Process for the extraction of valerian root. US 6 383 526; 2000.

  14. Sharapin N, Pinsón SR. Fundamentos de tecnología de productos fitoterapéuticos. Sta. Fe de Bogotá, DC, Colombia; 2000. p. 57-145.




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