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2012, Number 2

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Rev Cubana Pediatr 2012; 84 (2)

Primary hypothyroidism in patients with Down syndrome

Rivero GM, Cabrera PR, García GA, de León ONE

Language: Spanish
References: 25
Page:
PDF size: 126.86 Kb.


ABSTRACT

Introduction: hypothyroidism is the resulting clinical picture of a reduction in the biological activity of thyroid hormones due to their low production or little use. Its association with Down syndrome has been previously described by other authors; however, few studies on the frequency of association of both entities in Cuba and on the clinical form of hypothyroidism in these patients have been conducted.
Objectives: to evaluate the association of Down syndrome and hypothyroidism in patients seen at our service from January to December 2011.
Methods: twenty four patients with Down syndrome, aged 3 to 7 years, were attended at the endocrinology service of "William Soler" pediatric hospital.
Results: it was found that all these patients exhibited high values of hypophysial thyrotrop hormone, 18 had osseous age retardation (75 %) and 4 showed low size of less than 3 percentiles (16.6 %).
Conclusions: hypothyroidism is a frequent disease associated with Down syndrome, so its detection and early treatment in these children is of vital importance to improve their cognitive development and integral growth.


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