medigraphic.com
Boletín Médico del Hospital Infantil de México

2012, Number 3

<< Back Next >>

Bol Med Hosp Infant Mex 2012; 69 (3)

Meta-analysis of prognostic factors related to mortality in children with acute lymphoblastic leukemia

Villasís KMÁ, Arias GJ, Escamilla NA, Bonilla RJ

Language: Spanish
References: 32
Page: 175-189
PDF size: 4741.16 Kb.


ABSTRACT

Background. Acute lymphoblastic leukemia is one of the most common oncological diseases of the pediatric age. The study of the prognosis of these patients has led to identify variables that are associated with different endpoints. We conducted a systematic literature review and meta-analysis in order to have an overview of the factors associated with the prognosis, in terms of mortality, in pediatric patients with acute lymphoblastic leukemia (ALL).
Methods. The study selection was based on Medline. Using a peer-review process we identified the following group of publications: cohort studies of pediatric patients with ALL that were analyzed for prognostic factors associated with 5-year survival. In addition, we also included original or review articles in which prognostic factors or scales were related to mortality in ALL pediatric patients. Data collected are presented descriptively. In order to determine the magnitude of the factors identified associated with mortality, different meta-analyses were performed.
Results. We selected 29 publications. It was determined that the following patient characteristics at diagnosis are associated with more favorable survival: ages 1 to 9 years, female gender and without CNS infiltration. Favorable characteristics related to leukemic cells are white blood cell count ‹50,000 cell/µL, B-cell immunophenotype, DNA index 1.16–1.60 and absence of translocations t(9; 22), t(1; 19) and t(4, 11).
Conclusions. The study of prognostic factors of pediatric patients with ALL has contributed to reduced mortality; however, further research is required in this area.


REFERENCES

  1. Conter V, Rizari C, Sala A, Chiesa R, Cittero M. Leucemia linfoblástica aguda infantil. En: Sierrasesúmaga L, Antillón-Klussman F, Bernaola E, Patiño A, San Julián M, eds. Tratado de Oncología Pediátrica. Madrid: Pearson Education; 2006. pp. 251-293.

  2. Margolin JF, Poplack DG. Leukemia and lymphomas of childhood. En: DeVita VT, Lawrence TS, Rosenberg SA, eds. DeVita, Hellerman and Rosenberg’s Cancer: Principles and Practice of Oncology. Philadelphia: Lippincot Williams & Wilkins; 2008. pp. 2085-2093.

  3. Seibel NL. Treatment of acute lymphoblastic leukemia in children and adolescents: peaks and pitfalls. Hematology Am Soc Hematol Educ Program 2008:374-380.

  4. Lobato-Mendizábal E, López-Martínez B, Ruiz-Argüelles GJ. A critical review of the prognostic value of the nutritional status at diagnosis in the outcome of therapy of children with acute lymphoblastic leukemia. Rev Invest Clin 2003;55:31-35.

  5. Arya LS. Acute lymphoblastic leukemia: current treatment concepts. Indian Pediatr 2000;37:397-406.

  6. Pui CH. Acute lymphoblastic leukemia in children. Curr Opin Oncol 2000;12:3-12.

  7. Viana MB, Fernandes RA, de Oliveira BM, Murao M, de Andrade Paes C, Duarte AA. Nutritional and socio-economic status in the prognosis of childhood acute lymphoblastic leukemia. Haematologica 2001;86:113-120.

  8. Bhatia S. Influence of race and socioeconomic status on outcome of children treated for childhood acute lymphoblastic leukemia. Curr Opin Pediatr 2004;16:9-14.

  9. Pui CH, Schrappe M, Ribeiro RC, Niemeyer CM. Childhood and adolescent lymphoid and myeloid leukemia. Hematology Am Soc Hematol Educ Program 2004:118-145.

  10. Pieters R. Treatment of acute lymphoblastic leukaemia (ALL) in children and adolescents. 2007: SIOP Conference-International Society of Paediatric Oncology. Disponible en: http://www.cure-4kids.org/ums/home/public_area/pubcourse/?courses_id=78; http://www.cure4kids.org/private/courses_documents/m_259/Treatment%20of%20Acute%20Lymphoblastic%20Leukaemia%20(ALL)%20in%20Children%20and%20Adolecents.pdf

  11. Rogers PC. Relevance of nutrition to pediatric oncology. 2006: SIOP Conference-International Society of Paediatric Oncology. Disponible en: http://www.cure4kids.org/ums/home/public_area/pubcourse/?courses_id=60; http://www.cure4kids.org/ums/home/public_area/c4k_seminar/?ppts_id=1172

  12. Margolin JF, Steuber CP, Poplack DG. Acute lymphoblastic leukemia. En: Pizzo PA, Poplack DG, eds. Principles and Practice of Pediatric Oncology. Philadelphia: Lippincott Williams & Wilkins; 2006. pp 538-590.

  13. Bleyer WA, Sather H, Coccia P, Lukens J, Siegel S, Hammond GD. The staging of childhood acute lymphoblastic leukemia: strategies of the Children’s Cancer Study Group and a threedimensional technic of multivariate analysis. Med Pediatr Oncol 1986;14:271-280.

  14. Schmiegelow K, Forestier E, Hellebostad M, Heyman M, Kristinsson J, Söderhäll S, et al. Long-term results of NOPHO ALL-92 and ALL-2000 studies of childhood acute lymphoblastic leukemia. Leukemia 2010;24:345-354.

  15. Möricke A, Zimmermann M, Reiter A, Henze G, Schrauder A, Gadner H, et al. Long-term results of five consecutive trials in childhood acute lymphoblastic leukemia performed by the ALL-BFM study group from 1981 to 2000. Leukemia 2010;24:265-284.

  16. Salzer WL, Devidas M, Carroll WL, Winick N, Pullen J, Hunger SP, et al. Long-term results of the pediatric oncology group studies for childhood acute lymphoblastic leukemia 1984-2001: a report from the children’s oncology group. Leukemia 2010;24:355-370.

  17. Schultz KR, Pullen DJ, Sather HN, Shuster JJ, Devidas M, Borowitz MJ, et al. Risk- and response-based classification of childhood B-precursor acute lymphoblastic leukemia: a combined analysis of prognostic markers from the Pediatric Oncology Group (POG) and Children's Cancer Group (CCG). Blood 2007;109:926-935.

  18. Gaynon PS, Angiolillo AL, Carroll WL, Nachman JB, Trigg ME, Sather HN, et al. Long-term results of the children´s cancer group studies for childhood acute lymphoblastic leukemia 1983-2002: a Children’s Oncology Group Report. Leukemia 2010;24:285-297.

  19. Silverman LB, Stevenson KE, O'Brien JE, Asselin BL, Barr RD, Clavell L, et al. Long-term results of Dana-Farber Cancer Institute ALL Consortium protocols for children with newly diagnosed acute lymphoblastic leukemia (1985-2000). Leukemia 2010;24:320-334.

  20. Smith M, Arthur D, Camitta B, Carroll AJ, Crist W, Gaynon P, et al. Uniform approach to risk classification and treatment assignment for children with acute lymphoblastic leukemia. J Clin Oncol 1996;14:18-24.

  21. Escherich G, Horstmann MA, Zimmermann M, Janka-Schaub GE; COALL study group. Cooperative study group for childhood acute lymphoblastic leukemia (COALL): long-term results of trials 82, 85, 89, 92 and 97. Leukemia 2010;24:298-308.

  22. Mitchell C, Richards S, Harrison CJ, Eden T. Long-term followup of the United Kingdom medical research council protocols for childhood acute lymphoblastic leukaemia. 1980-2001. Leukemia 2010;24:406-418.

  23. Liang DC, Yang CP, Lin DT, Hung IJ, Lin KH, Chen JS, et al. Long-term results of Taiwan Pediatric Oncology Group studies 1997 and 2002 for childhood acute lymphoblastic leukemia. Leukemia 2010;24:397-405.

  24. Kamps WA, van der Pal-de Bruin KM, Veerman AJ, Fiocco M, Bierings M, Pieters R. Long-term results of Dutch Childhood Oncology Group studies for children with acute lymphoblastic leukemia from 1984 to 2004. Leukemia 2010;24:309-319.

  25. Tsuchida M, Ohara A, Manabe A, Kumagai M, Shimada H, Kikuchi A, et al. Long-term results of Tokyo Children’s Cancer Study Group trials for childhood lymphoblastic leukemia, 1984-1999. Leukemia 2010;24:383-396.

  26. Tsurusawa M, Shimomura Y, Asami K, Kikuta A, Watanabe A, Horikoshi Y, et al. Long-term results of the Japanese Childhood Cancer and Leukemia Study Group studies 811, 841, 874 and 911 on childhood acute lymphoblastic leukemia. Leukemia 2010;24:335-344.

  27. Conter V, Aricò M, Basso G, Biondi A, Barisone E, Messina C, et al. Long-term results of the Italian Association of Pediatric Hematology and Oncology (AIEOP) Studies 82, 87, 88, 91 and 95 for childhood acute lymphoblastic leukemia. Leukemia 2010;24:255-264.

  28. Stark B, Nirel R, Avrahami G, Abramov A, Attias D, Ballin A, et al. Long-term results of the Israeli National Studies in childhood acute lymphoblastic leukemia: INS 84, 89 and 98. Leukemia 2010;24:419-424.

  29. Stary J, Jabali Y, Trka J, Hrusak O, Gajdos P, Hrstkova H, et al. Long-term results of treatment of childhood acute lymphoblastic leukemia in the Czech Republic. Leukemia 2010;24:425-428.

  30. Pui CH, Pei D, Sandlund JT. Long term results of St Jude total therapy studies 11, 12, 13 A, 13B, and 14 for childhood acute lymphoblastic leukemia. Leukemia 2010;24:371-382.

  31. Hammond D, Sather H, Nesbit M, Miller D, Coccia P, Bleyer A, et al. Analysis of prognostic factors in acute lymphoblastic leukemia. Med Pediatr Oncol 1986;14:124-134.

  32. Greenberg PL, Gordeuk V, Issaragrisil S, Siritanaratkul N, Fucharoen S, Ribeiro RC. Major hematologic diseases in the developing world –new aspects of diagnosis and management of thalassemia, malarial anemia, and acute leukemia. Hematology Am Soc Hematol Educ Program 2001:479-498.




2020     |     www.medigraphic.com