Triana MME, Fernández MJI, Cabrera ZJL, Zapata VJ, Morejón RO

Language: Spanish
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ABSTRACT

Objectives: to describe the lipoproteic profiles depending on the type of diabetic macroangiopathy in the lower limbs, and to identify whether the profile of diabetics with the occluded type differs from that of the non-diabetics with peripheral arterial disease.
Methods: sixty patients with type 2 diabetes divided into groups according to the type of diabetic macroangiopathy, 20 non-diabetic patients with peripheral arterial disease and 20 healthy individuals were studied. Lipoprotein and glycemic control variables were studied. The TC/HDL-C, HDL-C/F and HDL2-C/HDL3-C ratios were estimated.
Results: when comparing the diabetics, it was found that the non- occluded type patients had lower concentration values for TC, LDL-C and CT/HDL-C than the group with vascular damage and the occluded type group (p< 0.05). In turn, the latter had lower values of HDL-C (p< 0.05) and higher figures of CT/HDL-C than the vascular damage group and the non-occluded type group (p< 0.05); no significant differences with respect to the peripheral arterial disease group was found in any of the variables. The group without vascular damage and the non-occluded type group showed increased concentration values of HDL3-C, HDL2-C and high values of HDL-C/F ratio (p< 0.05).
Conclusions: there are characteristic lipoprotein profiles for each type of diabetic macroangiopathy, which may be considered as high vascular risk in diabetics without vascular damage, with no vascular risk in the non-occluded type macroangiopathy patients and as acceptable vascular risk in the occluded type. This last group with occluded type macroangiopathy presents a lipoprotein profile similar to that of the non-diabetic group with peripheral arterial disease.