medigraphic.com
ISSN 0185-3252 (Print)
Revista de la Asociación Médica del Centro Médico ABC

2001, Number 3

<< Back Next >>

An Med Asoc Med Hosp ABC 2001; 46 (3)

Solid-pseudopapillary tumors of the pancreas

Cuesta MT, León BB, Baquera HJ, Cervantes MF, Quijano OF

Language: Spanish
References: 28
Page: 142-146
PDF size: 145.46 Kb.


ABSTRACT

The report of solid pseudopapillary pancreatic tumors, defined as potentially malignant or real malignant tumor has increased, due to their wide identification and characterization as anatomopathological entity. The tumor has a 2% of frequency considering all exocrine pancreatic neoplasms. They grow slowly with no exact correlation between the histological aspect and biological behaviour. We present herein two cases of female patients (24 and 15 year-old / Case 1 -and Case 2), with excellent evolution after the post-surgical diagnosis of solid-pseudopapillary pancreatic tumors, at the ABC Medical Center, in Mexico City. The two patients presented with abdominal pain; one of them (case 2) after a slight abdominal trauma. The tumors measured 14 cm and 12 cm respectively. Case 1 was predominantly cyst and case 2 was predominantly solid. The two cases had similar histological aspect: solid zones alternating with papillary areas and myxoid change. The immunostain was positive for vimentin and variable expression for neuroendocrine markers was found. The tumor cells expressed cytokeratin, and some of them were positive for progesteron receptors. The presence of ductuloinsular complexes in the residual pancreatic parenchyma was an interesting finding highlighted by the immunohistochemistry. Conclusions: Solid-pseudopapillary tumors present mainly in young women. Their solid-cystic gross aspect, its easy surgical resection, the large size, and the solid-papillary histological aspect, suggest the diagnosis and avoid excessive surgical resection.


REFERENCES

  1. Gruber GB. Pathologie der Bauchspeich el drüse (Mit Ausnahme der Langrhanschen In seln and Diabetesfrage). In: Henke F, Lubarsh D (eds). Handbuch der Speziellen Pathologischen Anatomic and Histologie. Berlin, Germany 1929: 211-621.

  2. Frantz VK. Tumors of the pancreas. In: Altas of Tumor Pathology. Section VII, fasc 27 and 28. Washington, DC: Armed Forces Institute of Pathology 1959.

  3. Compagno J, Oertel JE, Kremzar M. Solid and papillary epitelial neoplasm of the pancreas, probably of small duct origin: A clinico-pathologic study of 52 cases. Lab Inv 1979; 40: 248-249.

  4. Nishihara K, Tsuneyoshi M, Ohshima A, Yamaguchi K. Papillary cystic tumor of the pancreas. Is it a hormonedependent neoplasm? Pathol Res Pract 1993; 189: 521-526.

  5. Hernandez-Maldonado JJ, Rodriguez-Bigas M, Gonzalez de Pesante A et al. Papillary cystic neoplasm of the pancreas. A report of a case presenting with carcinomatosis. Am Surg 1989; 55: 552-569.

  6. Boor PJ, Swanson MR. Papillary cystic neoplasm of the pancreas. Am J Surg Pathol 1979; 3: 69-75.

  7. Hamoudi AB, Misugi K, Grosfeld JL, Reiner CB. Papillary epithelial neoplasm of pancreas in child. Cancer 1970; 26: 1126-1134.

  8. Valdes-Gonzalez R, Molinar L, Ortega-Salgado JA. Solid and cystic papillary epithelial neoplasms of the pancreas. Images of the tumor and follow-up. Gac Med Mex 1999; 135: 333-337.

  9. D’Amato A et al. Solid cystic tumor of the head of the pancreas in a young woman. Hepatogastroenterology 1998; 45: 541-544.

  10. Sharma MC, Safaya R, Chumber S, Srivastra A, Kataria R, Sharma R. Solid cystic tumour of the pancreas-clinico-pathological study of three cases. Indian J Pathol Microbiol 1997; 40: 157-160.

  11. Benjamin E, Wright DH. Adenocarcinoma of the pancreas of childhood: A report of two cases. Histopathology 1980; 4: 87-104.

  12. Lack EE, Levey R, Cassady JR, Vawter GF. Tumors of the exocrine pancreas in children and adolescents: A clinical and pathologic study of eight cases. Am J Surg Pathol 1983; 7: 319-327.

  13. Cubilla A L, Fitzgerald P J. Tumors of the exocrine pancreas. In: Hartmann WH. Atlas of tumor pathology. 2nd Series, fasc 19. Washington, DC: Armed Forces Institute of Pathology 1984: 201-207.

  14. Warren RB. Papillary cystic tumor of the pancreas. Arch Pathol Lab Med 1985, 109: 706-707.

  15. Lieber MR, Lack EE, Roberts JR Jr et al. Solid and papillary epithelial neoplasm of the pancreas: An ultrastructural and immunocytochemical study of six cases. Am J Surg Pathol 1987; 11: 85-93.

  16. Matsunou H, Konishi F. Papillary-cystic neoplasm of the pancreas: A clinicopathological study concerning the tumor aging and malignancy of nine cases. Cancer 1990; 65: 283-291.

  17. Kissane JM. Pancreatoblastoma and solid and cystic papillary tumor: Two tumors related to pancreatic ontogeny. Semin Diag Pathol 1994; 11: 152-164.

  18. Ladanyi M, Mulay S, Arsenau J. Estrogen and progesterone receptor determination in papillary cystic neoplasm of the pancreas. Cancer 1987; 60: 1604-1611.

  19. Pelosi G et al. Solid and cystic papillary neoplasm of the pancreas: a clinico-cytopathologic and immunocytochemical study of five new cases diagnosed by fine-needle aspiration cytology and review of the literature. Diagn Cytopathol 1995; 13: 233-246.

  20. Rückert K, Klöppel G, Treu H A. Solid-zystischer Acineeszell tumor des Pancreas. Dtschr Med Wschr 1982; 107: 1015-1020.

  21. Solcia E, Capella C, Klöppel G. Tumors of the exocrine pancreas. Atlas of tumor pathology. 3th serie, fasc 20. Washington DC: Armed Forces Institute of Pathology, 1997: 120-144.

  22. Karnauchow P N. Nesidioblastosis in adults without hiperfunction. Am J Clin Pathol 1982; 78: 511-513.

  23. Kamisawa T, Fukayama D, Koike M, Tatata I, Okamoto A. Socalled “papillary and cystic neoplasm of the pancreas”: An immunohistochemical and ultrastructural study. Acta Pathol Jpn 1987; 37: 785-794.

  24. Grant LD et al. Unbalanced chromosomal translocation, der (17) t (13;17) (q14;p11) in solid and cystic papillary epithelial neoplasm of the pancreas. Am J Surg Pathol 1996; 20: 339-345.

  25. Wrba F, Chott A, Ludvik B. Solid and cystic tumour of the pancreas: A hormonal-dependent neoplasm? Histopathology 1988; 12: 338-340.

  26. Johansson B, Bardi G, Heim S. Nonrandom chromosomal rearrangements in pancreatic carcinomas. Cancer 1992; 69: 1674-1681.

  27. Griffin C A et al. Chromosome abnormalities in pancreatic adenocarcinoma. Genes Chrom Cancer 1994; 9: 93-100.

  28. Wilson M B and col. Aspiration cytologic, ultrastructural, and DNA cytometric findings of solid and papillary tumor of the pancreas. Cancer 1992; 62: 2235-2243.




2020     |     www.medigraphic.com