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Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado

2012, Number 2

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Rev Esp Med Quir 2012; 17 (2)

Expression of sialic acids in cervical cancer. An study of a population from Regional Hospital Lic. Adolfo Lopez Mateos

Serrano BMÁ, López VJL, Serrano BJR

Language: Spanish
References: 21
Page: 115-118
PDF size: 370.39 Kb.


ABSTRACT

Background: There are high concentrations of sialic acid in the serum of patients with neoplasms of the cervix.
Objective: To determine if sialic acids are more sensitive diagnostic markers of cervical cancer than Pap smear, that is the gold standard in the early detection of cellular changes.
Patients and method: We included 1,500 patients attended at Colposcopy Clinic, Regional Hospital Lic. Adolfo Lopez Mateos, ISSSTE from September 1, 2010 to September 1, 2011.
Results: We collected 500 samples, 103 of them were diagnosed with high degree intraepithelial lesion by the technique of smear, and had elevated concentrations of sialic acids. Low-grade intraepithelial lesion was observed in 238 cases, as well as evidence of human papilloma virus with Pap smear. In 377 samples an increased concentration of sialic acids was found at Alpha position 2,3 and Alpha position 2,6.
Conclusions: It is advisable to highlight the great importance of complementing the exfoliative cytology with other immunohistochemical tests, such as determination of sialic acids expression to detect early cervical cancer, which is the second leading cause of death by cancer in women worldwide and the first in developing countries. In Mexico, it has been the most common neoplasm in recent decades and the leading cause of death by cancer among women.


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