Samper NJA, Llibre RJJ, Sánchez CC, Pérez RCL, Morales JE, Sosa PS, Solórzano RJ

Language: Spanish
References: 27
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ABSTRACT

Introduction: the mini-mental state examination (MMSE) is a brief, rapid test which may be performed in 5 to 10 minutes and is broadly used to evaluate cognitive decline.
Objective: characterize subjects with mild cognitive impairment based on results obtained with the mini-mental state examination.
Methods: a descriptive cross-sectional study was conducted with consecutive subjects aged ³ 50, who were evaluated in consultation at the dementia service of "Dr. Carlos J. Finlay" Central Military Hospital. The 46 subjects included were distributed in two groups: 26 with and 20 without mild cognitive impairment.
Results: alterations were found in the areas of Registration, Attention and Calculation and Recall. Registration and Recall were only affected in the mild cognitive impairment group. Total MMSE score was significantly lower in patients with mild cognitive impairment versus the group without the condition.
Conclusions: the subjects with mild cognitive impairment were basically characterized by total MMSE scores below normal values and the presence of alterations, mainly in the Recall area, but also in Registration.

REFERENCES

1. Reischies FM, Hellweg R. Prediction of deterioration in mild cognitive disorder in old age-: neuropsychological and neurochemical parameters of dementia diseases. Compr Psychiatry. 2000;41(2 Supl.1):66-75.

2. Lopera F. Anamnesis en el estudio del paciente con demencia. Rev Neurol. 2001;32 (12):1187-91.

3. Otero JL, Fontán L. La frontera entre el envejecimiento cognitivo normal y la enfermedad de Alzheimer. El concepto de deterioro cognitivo. Rev Med Uruguay. 2003;19:4-13.

4. Petersen RC, Morris JC. Clinical features. In: Petersen RC. Mild cognitive impairment: aging to Alzheimer's disease. New York: Oxford University Press; 2003. p.15-40.

5. Schmidtke K, Hermeneit S. High rate of conversion to Alzheimer's disease in a cohort of amnestic MCI patients. International Psychogeriatrics. 2008;20(1):96-108.

6. Mangone CA. Heterogeneidad clínica de la enfermedad de Alzheimer. Diferentes perfiles clínicos pueden predecir el intervalo de progresión. Rev Neurol. 2004;38(7):675-81.

7. Folstein M, Folstein S, MCHugh PR. Minimental State: a practical method for grading the cognitive state of the patients for the clinician. J Psychiatr Res. 1975;12:189-98.

8. Pérez O, Castillo V, Pérez J, Reiteri J, Gómez N, Roselló H, et al. Prevalencia de demencia en La Habana. Rev Esp Neurol. 1993;8:18-22.

9. Gómez Viera N, Bonnin Rodríguez BM, Gómez de Molina Iglesias MT, Yánez Fernández B, González Zaldívar A. Caracterización clínica de pacientes con deterioro cognitivo. Rev Cubana Med. 2003;42:127.

10. Casanova Carrillo P. Estudio clínico de las principales causas de trastornos cognoscitivos en la atención primaria. Rev Cubana Med Gen Integr. 2001;17:309-15.

11. Libre JJ, Guerra MA, Pérez Cruz H, Bayarre H, Fernández Ramírez S, González Rodríguez M, et al. Síndrome demencial y factores de riesgo en adultos mayores de 60 años residentes en La Habana. Rev Neurol. 1999;29(10):908-11.

12. Fontán Scheitler LE, Lorenzo-Otero L, Silveira Brussain A. Perfil de alteración en el Mini-Mental State Examination en pacientes con deterioro cognitivo leve. Rev Neurol. 2004;39(4):316-21.

13. Petersen RC. Conceptual overview. In: Petersen RC, ed. Mild cognitive impairment: aging to Alzheimer's disease. New York: Oxford University Press, Inc; 2003. p. 1-14.

14. Petersen RC. Mild cognitive impairment. Neurobiol Aging. 2002;23:S145.

15. Petersen RC. Mild cognitive impairment as a diagnostic entity. J Internal Med. 2004;256:183-94.

16. Petersen RC, Stevens JC, Ganguli M, Tangalos EG, Cummings JL, DeKosky ST. Practice parameter-early detection of dementia: mild cognitive impairment (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology. 2001;56:1133-42.

17. Hänninen T, Hallikainen M, Tuomainen S, Vanhanen M, Soininen H. Prevalence of mild cognitive impairment: a population-based study in elderly subjects. Acta Neurol Scand. 2002;106:148-54.

18. Barbeau E, Didic M, Tramoni E, Felician O, Joubert S, Sontheimer A, et al. Evaluation of visual recognition memory in MCI patients. Neurology. 2004;62:13-22.

19. Mungas D, Harvey D, Reed BR, Jagust WJ, DeCarli C, Beckett L, et al. Longitudinal volumetric MRI change and rate of cognitive decline. Neurology. 2005;65:565-71.

20. Zhang Y, Schuff N, Jahng GH, Bayne W, Mori S , Schad L, et al. Diffusion tensor imaging of cingulum fibers in mild cognitive impairment and Alzheimer's disease. Neurology. 2007;68:13-9.

21. Sánchez de Machado LM, Rubano Martínez MC, García Caamiña JD, Cantero Arias CR, Gárate Delgado LM, Florentín-Ocampo BR. Factores de comportamiento y déficit sensoriales identificatorios como predictores de la demencia tipo Alzheimer. Rev Neurol. 2007;44(4):198-202.

22. Barrero Hernández FJ, Vives Montero F, Morales Gordo B. Evaluación de la versión española del Memory Impairment Screen. Rev Neurol. 2006;43 (1):15-9.

23. McKahnn G, Drachman D, Folstein MD, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group. Neurology. 1984;34:939-44.

24. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th . Washington DC: American Psychiatric Association; 1994.

25. Xu G, Meyer JS, Thornby J, Chowdhury M, Quach M. Screening for mild cognitive impairment (MCI) utilizing combined mini-mental-cognitive capacity examinations for identifying dementia prodromes. Int J Geriatr Psychiatry. 2002;17:1027-33.

26. Vinyoles Bargalló E, Vila Doménech J, Argimon JM, Espinás Boquet J, Abo Pueyo T, Limón Ramírez E. Concordancia entre el Mini-examen cognoscitivo y el Mini-Mental State Examination en el cribado del déficit cognitivo. Aten Primaria. 2002;30(1):5-15.

27. Pérez Martínez DA, Baztán JJ, González Becerra M, Socorro A. Evaluación de la utilidad diagnóstica de una adaptación española del Memory Impairment Screen de Buschke para detectar demencia y deterioro cognitivo. Rev Neurol. 2005;40(11):644-8.