2011, Number 2
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Rev Cubana Invest Bioméd 2011; 30 (2)
Coronary calcium score and thickness of carotid middle intima in patients with suspicion of ischemic heart disease
Rodríguez HY, Mendoza-Rodríguez V, Llerena RLR, Olivares AEW, Zaldívar-O´Farri A, Rodríguez DY, San Román GE, Morales SE, Morales PLM, Hevia SL, López CG, González TA
Language: Spanish
References: 24
Page: 208-225
PDF size: 234.48 Kb.
ABSTRACT
INTRODUCTION: The coronary calcium's score and the quantification of media intima thickness are developing methods used in atherosclerosis diagnosis.
OBJECTIVE: To assess the coronary calcium score relation to classic cardiovascular risk factors and the carotid media intima thickness.
METHODS: Sample included 70 patients with suspicion of ischemic heart disease. In all of them the coronary calcium was quantified by 64 scans tomography and the media intima thickness by medias of ultrasound (US). Using continuously the dependent variable (coronary calcium score) we made a simple linear regression to obtain the regression coefficients (ß). The statistic significance level (α) used was of 95 % (value p< 0,05 as statistically significant).
RESULTS: Calcium score was higher in male sex subjects increasing linearly and annually with age in 11.4 UA. The correlation coefficient between calcium score and age was of 0.36 statistically significant (p= 0,002). The 88.9 % of patients with a media intima thickness greater than 1mm had some degree of coronary calcification, was twice greater than those with a media intima thickness less than 1 mm. Correlation value (r) with carotid media intima thickness was of 0.24 (p= 0.04).
CONCLUSIONS: Age, male sex and increase of carotid media intima thickness, is significantly related to presence and quantity of coronary calcification.
REFERENCES
Ibáñez B, Piñero A, Orejas M, Badimón JJ. Nuevas técnicas de imagen para la cuantificación de la carga aterosclerótica global. Rev Esp Cardiol. 2007;60:299-309.
Budoff MJ, McClelland RL, Nasir K, Greenland P, Kronmal RA, Kondos GT, et al. Cardiovascular events with absent or minimal coronary calcification: the Multi- Ethnic Study of Atherosclerosis (MESA). American Heart Journal. 2009;158:554-61.
Rampersaud E, Bielak LF, Parsa A, Shen H, Post W, Ryan KA, et al. The association of Coronary Artery Disease Risk Factors in Asymptomatic Adults. Am J Epidemiolol. 2008; 168:1016-24.
Bild DE, Detrano R, Peterson D. Ethnic differences in coronary calcification: The Multi-Ethnic Study of Atherosclerosis (MESA). Circulation. 2005;111:1313-20.
Caro P, Delgado R, Dapena F, Nuñez A. Valoración de las calcificaciones coronarias. Rev Nefrol. 2007;27:721-8.
Preis SR, Hwang SJ, Fox CS, Massaro JM, Levy D, Hoffmann U, et al. Eligibility of individuals with subclinical coronary artery calcium and intermediate coronary heart disease risk for reclassification (from the Framingham Heart Study. The American Journal of Cardiology. 2009;103:1710-5.
Hoffmann U, Massaro JM, Fox CS, Manders E, O'Donnell CJ. Defining normal distributions of coronary artery calcium in women and men (from the Framingham Heart Study). The American Journal of Cardiology. 2008;102:1136-41.
Arad Y, Goodman KJ, Roth M, Newstein D, Guerci AD. Coronary calcification, coronary disease risk factors, C-reactive protein, and atherosclerotic cardiovascular disease events: the St. Francis Heart Study. Journal of the American College of Cardiology. 2005;46:158-65.
Terry GJ, Carr J, Tang R, W. Evans G, O. Kouba E , Shi R, et al. Coronary Artery Calcium Outperforms Carotid Artery Intima-Media Thickness as a Noninvasive Index of Prevalent Coronary Artery Stenosis. Arterioscler Thromb Vasc Biol. 2005;25:1723-8.
Nasir K, Vasamreddy C, Blumenthal RS, Rumberger JA. Comprehensive coronary risk determination in primary prevention: an imaging and clinical based definition combining computed tomographic coronary artery calcium score and national cholesterol education program risk score. International Journal of Cardiology. 2006;110:129-36.
Wexler L, Brundage B, Crouse J, Detrano R, Fuster V, Maddhl J, et al. Coronary artery calcification: pathophysiology, epidemiology, imaging methods, and clinical implications; a statement for health professionals from the American Heart Association. Circulation. 1996; 94:1175-92.
Blaha M, Budoff MJ, Shaw LJ, Khosa F, Rumberger JA, Berman D, et al. Absence of coronary artery calcification and all-cause mortality. JACC. 2009;2:692-700.
Budoff MJ, Gul KM. Expert review on coronary calcium. Vascular Health and Risk Management. 2008;4:315-24.
Romanensa MR, Miserezb A, Ackermannc F, Riesend W, Spencee D, Dariolif R. Imaging as a cardiovascular risk modifier in primary care patients using predictor models of the European and international atherosclerosis societies. Kardiovaskuläre Medizin. 2007;10:139-50.
Rohani M, Jogestrand T, Ekberg M, van der Linden J, Kallner G, Jussila R, et al. Interrelation between the extent of atherosclerosis in the thoracic aorta, carotid intima-media thickness and the extent of coronary artery disease. Atherosclerosis. 2005;179:311-6.
Wagenknecht LE, Langefeld CD, Carr JJ, Riley W, Freedman BI, Moossavi S, et al. Race-specific relationships between coronary and carotidartery calcification and carotid intimal medial thickness. Stroke. 2004;35:97-9.
Hallerstam S, Larsson PT, Zuber E, Rosfors S. Carotid atherosclerosis is correlated with extent and severity of coronary artery disease evaluatedby myocardial perfusion scintigraphy. Angiology. 2004;55:281-8.
Pasierski T, Sosnowski C, Szulczyk A, Leszczynski L, Rewicki M. The role of ultrasonography of the peripheral arteries in diagnosing coronary artery disease. Pol Arch Med Wewn. 2004;111:21-25.
Alan S, Ulgen MS, Ozturk O, Alan B, Ozdemir L, Toprak N. Relation between coronary artery disease, risk factors and intima-media thickness of carotid artery, arterial distensibility, and stiffness index. Angiology. 2003;54:261-7.
Ogata T, Yasaka M, Yamagishi M, Seguchi O, Nagatsuka K, Minematsu K. Atherosclerosis found on carotid ultrasonography is associated with atherosclerosis on coronary intravascular ultrasonography. J Ultrasound Med. 2005;24:469-74.
Johnsen SH, Mathiesen EB, Joakimsen O, Stensland E, Wilsgaard T, Lochen ML, et al. Carotid atherosclerosis is a stronger predictor of myocardial infarction in women than in men: a 6-year follow-up study of 6226 persons: the Tromso Study. Stroke. 2007;38:2873-80.
Arad Y, Spadaro LA, Roth M, Scordo J, Goodman K, Sherman S, et al. Correlations between vascular calcification and atherosclerosis: a comparative electron beam CT study of the coronary and carotid arteries. J Comput Assist Tomogr. 1998;22:207-11.
Oei HH, Vliegenthart R, Hak AE, Iglesias del Sol A, Hofman A, Oudkerk M, et al. The association between coronary calcification assessed by electron beam computed tomography and measures of extracoronary atherosclerosis: the Rotterdam Coronary Calcification Study. J Am Coll Cardiol. 2002;39:1745-51.
Newman AB, Naydeck BL, Sutton-Tyrrell K, Edmundowicz D, O'Leary D, Kronmal R, et al. Relationship between coronary artery calcification and other measures of subclinical cardiovascular disease in older adults. Arterioscler Thromb Vasc Biol. 2002;22:1674-8.