medigraphic.com
ISSN 1561-2988 (Print)

2012, Number 2

<< Back Next >>

Rev Cubana Farm 2012; 46 (2)

Storage condition stability of Tamarindus indica L. leaf tablets

Rodríguez AJR, Lafourcade PA, Escalona AJC, Iraizoz CA, Sierra GG

Language: Spanish
References: 20
Page: 240-248
PDF size: 71.32 Kb.


ABSTRACT

Objective: to evaluate the physical stability, chemical and microbiological stability of the Tamarindus indica L tablets on shelf.
Methods: the physical and mechanical properties, the polyphenol concentrations, the dissolution profiles and the microbiological quality were evaluated for two years. Tablets were packed in high density PVP flasks and were stored in a dry and fresh place. Each of the properties was determined every three months.
Results: throughout the study, the tablets kept their characteristic light brown color, the same odour resembling ripe fruit and the same physical appearance. The physical properties remained unchanged during two years: hardness was higher than 5 kg/f (Monsanto), friability lower than 1 %, mass and height were within the allowable variability. Disintegration time was less than 10 min. The released percentage of polyphenols in 30 min was over 87 % in the course of study.
Conclusions: it was demonstrated that 120 mg Tamarind tablets can keep their physical-mechanical properties, the polyphenol concentrations and the microbiological and biopharmaceutical quality for 2 years. Thin layer chromatographic studies are currently conducted to assure more precisely the chemical stability of the tablets.


REFERENCES

  1. Dehesa MA, Jáuregui O, Cañigueral S. Estudio por HPLC-MS/MS de compuestos fenólicos presentes en las hojas de Tamarindus indica L. Rev de Fitoterapia 2006;6. [citado 3 Nov. 2008]. Disponible en: http://www.fitoterapia.net

  2. Escalona AJC, Pérez RR, Licea JI, Rodríguez AJR, Argota-Coello H, Cañizares-Lay J, et al. Chemical constituents of Tamarindus indica L. leaves. Rev Cubana Quím. 2010;23(3);65-71.

  3. Escalona AJC, Dahesa MA, Boizzan ML. Evaluación preclínica del efecto hepatoprotector de extractos flavonólicos de las hojas de Tamarindus indica L. Etnomedicine. 1995;1:147-56.

  4. Jouyex M, Mortimer F, Fleurentin J. Screening of antiradical, antilipoperoxidant and hepatoprotective effects of nine plants extracts used in Caribbean folk medicine. Phytotherapy Res. 1995;9:228-30.

  5. Escalona AJC, Peres RR, Urdaneta I, Camacho M, Rodriguez AJR, Licea JI. Evaluation of the antimicrobial activity of extracts from Tamarindus indica L. leaves. Pharmacognosy Magazine. 2010:6(23):242-7.

  6. Souza CRF. Comparative Study of the Production of Dried Extract of Bauhinia forficata Link by the Spray Dryer and the Spouted Bed Processes (Disertación), USP. Brazil. 2003. p. 180. Available from: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-66322005000200011

  7. Souza CRF, Oliveira WP. Spouted Bed Drying of Bauhinia forficata Link Extract: The Effects of Feed Atomizer Position and Operating Conditions on Equipment Performance and Product Properties. Braz J Chem Eng. 2005;22(2):239.

  8. Rodríguez AJR, Lafourcade PA, Escalona AJC. Formulación de comprimidos de tamarindo por el método de granulación húmeda. Rev Cubana Farm [Internet]. 2011 Sep [citado 18 Dic 2011];45(3):414-422. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034-75152011000300010&lng=es

  9. Rowe RC, Sheskey PJ, Owen SC. Handbook of Pharmaceutical Excipient. New York: Pharmaceutical Press & American Pharmacists Association; 2009.

  10. Rodríguez AJR, Lafourcade PA, Escalona AJ. Estudio de la estabilidad química acelerada de las tabletas de Tamarindus indica L. Rev Cubana Quím. 2011;23(1):9-16.

  11. Iraizoz A, Bilbao RO, Barrios MA. Conferencias de Tecnología Farmacéutica II. La Habana: IFAL. Universidad de La Habana, ENPES; 1992.

  12. United States Pharmacopeia. The official compendia of standards. Version 1.0. For Windows. New York: Pharm Convention Inc.; 2007.

  13. British Pharmacopoeia (BP). London: Stationary Office; 2010.

  14. Rodríguez AJR, Escalona AJC, Lafourcade PA, Rodríguez RR, Batista RA. Validación del método de cuantificación de polifenoles en el extracto fluido de Tamarindus indica L. Rev Cubana Quím. 2011;23(1):42-50.

  15. Lachman L, Lieberman H. Pharmaceutical Dosage Forms, Tablets. New Cork: Marcel Dekker; 1981.

  16. Martinelo F, Soares FM, Franco JJ, Santos AC, Sugohara A, García SB, et al. Hypolipemic and antioxidant activities from Tamarindus indica L. pulp fruit extract in hypercholesterolemic hamsters. Food Chem Toxicol. 2006;44:810-8.

  17. Gupta, AK, Chitme H, Dass DK, Misra N. Antioxidant activity of Chamomile recutita capitula methanolic extracts against CCl4-induced liver injury in rats. J Pharmacol Toxicol. 2006b;1:101-7.

  18. Troncoso L, Guija E. Efecto antioxidante y hepatoprotector del Petroselinum sativum (perejil) en ratas, con intoxicación hepática inducida por paracetamol. An Fac Med (Lima). 2007;68(4):333-43.

  19. Heba E, Youssif AA, Khedr Z, Mohamed ZM. Hepatoprotective and antioxidant effects of Zizyphus spina-christi fruits on carbon tetrachloride induced hepatotoxicity in rats. Nature Sci. 2011;9(2):1-7.

  20. Doughary JH. Antimicrobial activity of Tamarindus indica Linn. Trop J Pharm Res. 2006;5;597-603.




2020     |     www.medigraphic.com