medigraphic.com
ISSN 1561-2988 (Print)

2011, Number 3

<< Back Next >>

Rev Cubana Farm 2011; 45 (3)

Encapsulation of a sunscreen (avobenzone) in liposomes

Pinillos MJF, Gallardo CC

Language: Spanish
References: 19
Page: 331-340
PDF size: 316.36 Kb.


ABSTRACT

This study was aimed at confirming the optimization of Avobenzone encapsulation in liposomes, and at evaluating whether this is a physical barrier to protect AVO from photodegradation in presence of octylmetoxycinnamate or not. An experimental design served to optimize the processes of encapsulation. The results showed a significant increase in the encapsulation efficiency since optimal relationship between the encapsulating agent and the agent to be encapsulated, as well as adequate interactions among the studied factors were found. The values of encapsulation efficiency were roughly 90.00 % and the particle size obtained was 9.156 mm. The Avobenzone photostability in presence of UVB filter octylmetoxycinnamate improved when being encapsulated in liposomes, with a degradation percentage of 22.07 % against 32.96 % of the non-encapsulated, and the colloidal stabilization of liposomal dispersion improved with the use of 1.00 % Carbopol 940. It can be concluded that the encapsulation of avobenzone in liposomes using isolecitine is highly efficient, and it is confirmed that Avobenzone photodegradation decreases when it is encapsulated, regardless of octylmetoxycinnamate.


REFERENCES

  1. Walters HA, Roberts MS. Dermatologic, Cosmeceutic, and Cosmetic Development. Therapeutic and Novel Approaches. Nueva York: Informa Healthcare; 2008.

  2. Barel AO, Paye M, Maibach H. Handbook of Cosmetic Science and Technology. 3a ed. Nueva York: Informa Healthcare; 2009.

  3. Gonzales S, Fernandez-Lorent EM, Gilaberte-Calzada Y. The Latest on Skin Protection. Clin Dermatol. 2008;26:614-26.

  4. Jacobs A, Brown P, Wilkin J. FDA considerations for sunscreens: New UV filters. Photochem Photobiol. 1999;69:53S-58S.

  5. Bouillon C. Recent advances in sun protection. J DermatolSci. 2000;23 (Suppl): S57-61.

  6. Chatelain E, Gabard B. Photostabilization of butyl methoxydibenzoylmethane (Avobenzone) and ethylhexylmethoxycinnamate by bis-ethylhexyloxyphenolmethoxyphenyltriazine (Tinosorb S), a new UV broadband filter. Photochem Photobiol. 2001;74:401-6.

  7. Pathak MA. Sunscreens: progress and perspectives on photoprotection of human skin against UVB and UVA radiation. J Dermatol. 1996;23:783-800.

  8. Schwack W, Rudolph T. Photochemistry of dibenzoyl methane UVA filters. I. J PhotochPhotobio B, 1995;28(3):229-34.

  9. Mturi GJ, Martincigh BS. Photostability of the sunscreening agent 4-tert-butyl- 4'-methoxydibenzoylmethane (avobenzone) in solvents of different polarity and proticity. J PhotochPhotobio A. 2008;200(2-3):410-20.

  10. Dondi D, Albini AA, Serpone N. Interactions between different solar UVB/UVA filters contained in commercial suncreams and consequent loss of UV protection. PhotochPhotobioSci, 2006;(5):835-43.

  11. Roscher NM, Lindemann MK, Kong SB, Cho CG, Jiang P. Photodescomposition of several compounds commonly used as sunscreens agents. J PhotochPhotobio A. 1994;80:417-421.

  12. Bangham AD, Standish MM, Watkins JC. Diffusion of univalent ions across the lamellae of swollen phospholipids. J Mol Biol. 1965;13:238-52.

  13. Vargha-Butler EI, Hurst EL. Study of liposomal drug delivery systems 1. Surface characterization of steroids loaded MLV liposomes. Colloid Surface B. 1995;3(2):287-95.

  14. Marrot L, Belaidi JP, Lejeune F, Meunier JR, Asselineau D, et al. Photostability of sunscreen products influences the efficiency of protection with regard to UV-induced genotoxic or photoageingrelated endpoints, Br J Dermatol. 2004;151:1234-44.

  15. López O, Cócera M, Walther P, Wehrli E, Coderch L, Parra JL, et al. Liposomes as protective agents of stratum corneum against octylglucoside: a study based on high-resolution, low-temperature scanning electron microscopy. Micron. 2001; 32(2):201-5.

  16. Betz G, Aeppli A, Menshutina N, Leueunberger H. In vivo comparison of various liposome formulations for cosmetic application. Int J Pharm. 2005;296:44-54.

  17. Vallejo JJ, Mesa M. Gallardo C. Evaluation of the avobenzone photostability in solvents used in cosmetic formulations, Vitae. 2011;18(1):63-71.

  18. Scalia S, Tursilli R, Sala N, Iannuccelli V. Encapsulation in lipospheres of the complex between butyl methoxydibenzoylmethane and hydroxypropyl-[beta]- cyclodextrin. Int J Pharm, 2006;320(1-2):79-85.

  19. Gaspar LR, Maia Campos PMBG. Evaluation of the photostability of different UV filter combinations in a sunscreen. Int J Pharm, 2006;307(2):123-8.




2020     |     www.medigraphic.com