Antonio-Valdiviezo A, Gómez-Rivera S, Martínez-Torres J

Language: Spanish
References: 22
Page: 557-560
PDF size: 224.76 Kb.

ABSTRACT

Background: The progressive multifocal leukoencephalopathy (PML) is a disease histological anatomy characterized by the presence of multifocal areas of demyelization spread out over the central nervous system.The PML is caused by the polyomavirus, a papovavirus.
Clinical case: a female patient with 27 years aged began with malaise, musculosqueletal pain, paresthetic, hyperthermia and diaphoresis; 72 hours later she presented quadriplegic with neurological damage that progressed to stupor and generalized clonic-tonic seizures. The spinal fluid showed no infection signs. The simple and contrasted computed tomography (CT) was normal. The magnetic resonance imaging (MRI) from encephalon reported lesion in white substance in hemispheres, callosal corpus, cerebellum and tallus. Angioresonance showed an increased number of hyperdense areas in the white substance.
Final pathological diagnosis was: progressive multifocal leukoencephalopathy. There was no confirmation of immunological disease after the exhaustive studies realized. The patient’s survival was two years after the diagnosis was made.

REFERENCES

1. Gnocchi M, Salamano R, Mañana G, Lasalvia E, Riera R, Hernández O. Leucoencefalopatía multifocal progresiva: a propósito de un caso clínicopatológico en un paciente infectado por VIH. Rev Med Uruguay 2003;19:78-82.

2. Cedeno F, Penalva-de Oliveira AC, Vidal JE, Trujillo JR. Virus neurotrópicos: el virus JC y la leucoencefalopatía multifocal progresiva. Rev Mex Neuroci 2006;7(1):46-54.

3. Gatto EM, Zurr MC, Alctlas J, Tartaglione J. Imágenes de difusión en leucoencefalopatía multifocal progresiva. Rev Neurol Arg 2003;20(4): 226- 229.

4. Sedel F, Tourbah A, Baumann N, Fontaine B, Aubourg P, et al. Adult onset hereditary leukoencephalopathies. Revue Neurologique 2005;161(10): 916-931.

5. Bartt RE. Multiple sclerosis, natalizumab therapy, and progressive multifocal leukoencephalopathy. Curr Opin Neurol 2006;19(4):341-349.

6. Freim Wahl SG, Folvik MR, Torp SH. Progressive multifocal leukoencephalopathy in a lymphoma patient with complete remission after treatment with cytostatics and rituximab: case report and review of the literature. Clin Neuropathol 2007;26 (2):68-73.

7. Rieder CR, Ziomkowski SC. Head tremor and progressive multifocal leukoencephalopathy in AIDS patients: report of two cases. Arq Neuropsiquiatr 2005;63(1):150-153.

8. De Luca A, Giancola ML, Ammassari A, et al. Potent anti-retroviral therapy with or without cidofovir for AIDS-associated progressive multifocal leukoencephalopathy: extended follow-up of an observational study. J Neurovirol 2001;7:364-368.

9. Blanco-Barrios A, Zancada Díaz-de Entre Sotos F, Gutiérrez-Vivas A, Calderón-Mario N. Progressive multifocal leukoencephalopathy in AIDS patients. Hepatotoxicity of HAART in patients with hepatitis B or C. An Med Intern 2005;22(8):376-378.

10. Garcia AM, Corral I, Cobo J, Quereda C. Pure alexia secondary to progressive multifocal leukoencephalopathy as first manifestation of HIV infection. Neurologia 2006;21(4)213-217.

11. Giessen HJ, Neuen-Jacob E, Dörries K, Jablonowski H, Roick H, Arendt G. Diagnostic criteria and clinical procedures in HIV-1 associated progressive multifocal leukoencefalopathy. J Neurol Sci 1997; 147:63-72.

12. Gnocchi M, Salamano R, Mañana G, Lasalvia E, Riera R, Hernández O. Leucoencefalopatía multifocal progresiva: a propósito de un caso clínicopatológico en un paciente infectado por VIH. Rev Med Uruguay 2003;19:78-82.

13. Cedeno F, Penalva-de Oliveira AC, Vidal JE, Trujillo JR. Virus neurotrópicos: el virus JC y la leucoencefalopatía multifocal progresiva. Rev Mex Neuroci 2006;7(1):46-54.

14. Gatto EM, Zurr MC, Alctlas J, Tartaglione J. Imágenes de difusión en leucoencefalopatía multifocal progresiva. Rev Neurol Arg 2003;20(4): 226-229.

15. Sedel F, Tourbah A, Baumann N, Fontaine B, Aubourg P, et al. Adult onset hereditary leukoencephalopathies. Revue Neurologique 2005;161(10): 916-931.

16. Bartt RE. Multiple sclerosis, natalizumab therapy, and progressive multifocal leukoencephalopathy. Curr Opin Neurol 2006;19(4):341-349.

17. Freim Wahl SG, Folvik MR, Torp SH. Progressive multifocal leukoencephalopathy in a lymphoma patient with complete remission after treatment with cytostatics and rituximab: case report and review of the literature. Clin Neuropathol 2007;26 (2):68-73.

18. Rieder CR, Ziomkowski SC. Head tremor and progressive multifocal leukoencephalopathy in AIDS patients: report of two cases. Arq Neuropsiquiatr 2005;63(1):150-153.

19. De Luca A, Giancola ML, Ammassari A, et al. Potent anti-retroviral therapy with or without cidofovir for AIDS-associated progressive multifocal leukoencephalopathy: extended follow-up of an observational study. J Neurovirol 2001;7:364-368.

20. Blanco-Barrios A, Zancada Díaz-de Entre Sotos F, Gutiérrez-Vivas A, Calderón-Mario N. Progressive multifocal leukoencephalopathy in AIDS patients. Hepatotoxicity of HAART in patients with hepatitis B or C. An Med Intern 2005;22(8):376-378.

21. Garcia AM, Corral I, Cobo J, Quereda C. Pure alexia secondary to progressive multifocal leukoencephalopathy as first manifestation of HIV infection. Neurologia 2006;21(4)213-217.

22. Giessen HJ, Neuen-Jacob E, Dörries K, Jablonowski H, Roick H, Arendt G. Diagnostic criteria and clinical procedures in HIV-1 associated progressive multifocal leukoencefalopathy. J Neurol Sci 1997; 147:63-72.