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2008, Number 5

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Rev Med Inst Mex Seguro Soc 2008; 46 (5)

Larrea Tridentata. Effect on a Non-Metabolic Model of Urolithiasis in Rats

Portilla-de Buen E, Ramos L, Aguilar A, Ramos A, García-Martínez D, Cárdenas A, Rodríguez-Reynoso S, Leal C

Language: Spanish
References: 56
Page: 519-522
PDF size: 101.75 Kb.


ABSTRACT

Objective: to evaluate the effect of L. tridentata infusion on the development of urinary calculi in a non-metabolic model.
Methods: male Wistar rats were divided into two groups (n = 10 each). The experimental group received 1 mL of oral L. tridentata infusion three times daily for 95 days. Control group received 1 mL tap water. Five days after initiating treatment, urolithiasis was induced inserting a series of 15 knots of 5-0 chromic catgut into the urinary bladder. Measurements included body weight and water intake, complete blood counts, glucose, BUN, creatinine, bacterial culture, and weight of urinary stones and sands.
Results: no statistically significant differences were found between groups for any variable.
Conclusions: an infusion of L. tridentata was not effective in the prevention of urolith formation in the suture-induced rat model. It produced no alterations in body weight gain, blood counts, or water intake. Future work is needed to completely rule out any effect of the plant on urolith formation.


REFERENCES

  1. Resnick MI, Persky L. Summary of the National Institutes of Arthritis, Diabetes, Digestive and Kidney Diseases. Conference on Urolithiasis: State of the Art and Future Research Needs. J Urol 1995; 153(1):4-9.

  2. Aguilar A, Camacho JR, Chino S, Jácquez P, López ME. Herbario medicinal del Instituto Mexicano del Seguro Social. México: Instituto Mexicano del Seguro Social; 1994.

  3. McDaniel S, Goldman GD. Consequences of using escharotic agents as primary treatment for nonmelanoma skin cancer. Arch Dermatol 2002;138:1593-1596.

  4. Arteaga S, Andrade-Cetto A, Cárdenas R. Larrea tridentata (creosote bush), an abundant plant of Mexican and US-American deserts and its metabolite nordihydroguaiaretic acid. J Ethnopharmacol 2005; 98(3):231-239.

  5. Granados H, Cárdenas R. Cálculos biliares en el hamster dorado. XXXVII. Acción preventiva de "gobernadora" (Larrea tridentata) en la colelitiasis pigmentaria producida por la vitamina A. Rev Gastroenterol Mex 1994;59:31-35.

  6. Meckes M, David-Rivera AD, Nava-Aguilar V, Jiménez A. Activity of some Mexican medicinal plant extracts on carrageenan-induced rat paw edema. Phytomedicine 2004;11(5):446-451.

  7. Gnabre JN, Brady JN, Clanton DJ, Ito Y, Dittmer J, Bates RB, et al. Inhibition of human immunodeficiency virus type 1 transcription and replication by DNA sequence-selective plant lignans. Proc Natl Acad Sci USA 1995;92:11239-1143.

  8. Gonzales M, Bowden T. Nordihydroguaiaretic acid-mediated inhibition of ultraviolet B-induced activator protein-1 activation in human keratinocytes. Mol Carcinog 2002;34:102-111.

  9. Luo J, Chuang T, Cheung J, Quan J, Tsai J, Sullivan C, et al. Masoprocol (nordihydroguaiaretic acid): a new antihyperglycemic agent isolated from the creosote bush (Larrea tridentata). Eur J Pharmacol 1998;346:77-79.

  10. Abou-Gazar H, Bedir E, Takamatsu S, Ferreira D, Khan IA. Antioxidant lignans from Larrea tridentata. Phytochemistry 2004;65:2499-505.

  11. Culver CA, Michalowski SM, Maia RC, Laster SM. The anti-apoptotic effects of nordihydroguaiaretic acid: inhibition of cPLA2 activation during TNF-induced apoptosis arises from inhibition of calcium signaling. Life Sci 2005;77:2457-2470.

  12. Lambert JD, Sang S, Dougherty A, Caldwell CG, Meyers RO, Dorr RT, et al. Cytotoxic lignans from Larrea tridentata. Phytochemistry 2005;66:811-815.

  13. Portilla E, Ramos A, Ramos ML, de Buen N, García D, Rodríguez-Reynoso S, et al. A model of sutureinduced urolithiasis with urographic control in the bladder of the rat. J Invest Surg 1999;12:205-211.

  14. D'Silva M, Gittes RF, Wolf P, Pirenne J, Munger K, Pascual J, et al. Rat kidney transplantation update with special reference to vesical calculi. Microsurgery 1990;11:169-176.

  15. Sheikh NM, Philen RM, Love LA. Chaparral-associated hepatotoxicity. Arch Intern Med 1997; 157:913-919.

  16. Smith AY, Feddersen RM, Gardner KD, Davis CJ. Cystic renal cell carcinoma and acquired renal cystic disease associated with consumption of chaparral tea: a case report. J Urol 1994;152(6 pt 1):2089-2091.

  17. Pittler MH, Ernst E. Systematic review: hepatotoxic events associated with herbal medicinal products. Aliment Pharmacol Ther 2003;18:451-471.

  18. Stedman C. Herbal hepatotoxicity. Semin Liver Dis 2002;22(2):2002.

  19. Brent J. Three new herbal hepatotoxic syndromes. Clin Toxicol 1999;37(6):715-719.

  20. Steenkamp V, Stewart MJ. Nephrotoxicity associated with exposure to plant toxins, with particular reference to Africa. Ther Drug Monit 2005; 27(3):270-277.

  21. Alderman S, Kailas S, Goldfarb S, Singaram C, Malone DG, et al. Cholestatic hepatitis after ingestion of chaparral leaf: confirmation by endoscopic retrograde cholangiopancreatography and liver biopsy. J Clin Gastroenterol 1994;19:242-247.

  22. Lambert JD, Zhao D, Meyers RO, Kuester RK, Timmermann BN, Dorr RT. Nordihydroguaiaretic acid: hepatotoxicity and detoxification in the mouse. Toxicon 2002;40(12):1701-1708.

  23. Sorensen JS, Heward E, Dearing MD. Plant secondary metobolites alter the feeding patterns of mammalian herbivore (Neotoma lepida). Oecologia 2005;146(3):415-422.

  24. Travis CC, White RK, Ward RC. Interspecies extrapolation of pharmacokinetics. J Theor Biol 1990; 142:285-304.

  25. Obermeyer WR, Musser SM, Betz JM, Casey RE, Pohland AE, Page SW. Chemical studies of phytoestrogens and related compounds in dietary supplements: flax and chaparral (43824). Proc Soc Exp Biol Med 1995;208:6-12.

  26. Heron S, Yarnell E. The safety of low-dose Larrea tridentata (DC) Coville (creosote bush or chaparral): a retrospective clinical study. J Altern Complement Med 2001;7(2):175-185.

  27. Milroy E. An experimental study of the calcification and absorption of polyglycolic acid and catgut sutures within the urinary tract. Invest Urol 1976;14(2):141-142.

  28. Verástegui MA, Sánchez CA, Heredia NL, García- Alvarado JS. Antimicrobial activity of extracts of three major plants from the Chihuahuan desert. J Ethnopharmacol 1996;52:175-177.

  29. Resnick MI, Persky L. Summary of the National Institutes of Arthritis, Diabetes, Digestive and Kidney Diseases. Conference on Urolithiasis: State of the Art and Future Research Needs. J Urol 1995; 153(1):4-9.

  30. Aguilar A, Camacho JR, Chino S, Jácquez P, López ME. Herbario medicinal del Instituto Mexicano del Seguro Social. México: Instituto Mexicano del Seguro Social; 1994.

  31. McDaniel S, Goldman GD. Consequences of using escharotic agents as primary treatment for nonmelanoma skin cancer. Arch Dermatol 2002;138:1593-1596.

  32. Arteaga S, Andrade-Cetto A, Cárdenas R. Larrea tridentata (creosote bush), an abundant plant of Mexican and US-American deserts and its metabolite nordihydroguaiaretic acid. J Ethnopharmacol 2005; 98(3):231-239.

  33. Granados H, Cárdenas R. Cálculos biliares en el hamster dorado. XXXVII. Acción preventiva de "gobernadora" (Larrea tridentata) en la colelitiasis pigmentaria producida por la vitamina A. Rev Gastroenterol Mex 1994;59:31-35.

  34. Meckes M, David-Rivera AD, Nava-Aguilar V, Jiménez A. Activity of some Mexican medicinal plant extracts on carrageenan-induced rat paw edema. Phytomedicine 2004;11(5):446-451.

  35. Gnabre JN, Brady JN, Clanton DJ, Ito Y, Dittmer J, Bates RB, et al. Inhibition of human immunodeficiency virus type 1 transcription and replication by DNA sequence-selective plant lignans. Proc Natl Acad Sci USA 1995;92:11239-1143.

  36. Gonzales M, Bowden T. Nordihydroguaiaretic acid-mediated inhibition of ultraviolet B-induced activator protein-1 activation in human keratinocytes. Mol Carcinog 2002;34:102-111.

  37. Luo J, Chuang T, Cheung J, Quan J, Tsai J, Sullivan C, et al. Masoprocol (nordihydroguaiaretic acid): a new antihyperglycemic agent isolated from the creosote bush (Larrea tridentata). Eur J Pharmacol 1998;346:77-79.

  38. Abou-Gazar H, Bedir E, Takamatsu S, Ferreira D, Khan IA. Antioxidant lignans from Larrea tridentata. Phytochemistry 2004;65:2499-505.

  39. Culver CA, Michalowski SM, Maia RC, Laster SM. The anti-apoptotic effects of nordihydroguaiaretic acid: inhibition of cPLA2 activation during TNF-induced apoptosis arises from inhibition of calcium signaling. Life Sci 2005;77:2457-2470.

  40. Lambert JD, Sang S, Dougherty A, Caldwell CG, Meyers RO, Dorr RT, et al. Cytotoxic lignans from Larrea tridentata. Phytochemistry 2005;66:811-815.

  41. Portilla E, Ramos A, Ramos ML, de Buen N, García D, Rodríguez-Reynoso S, et al. A model of sutureinduced urolithiasis with urographic control in the bladder of the rat. J Invest Surg 1999;12:205-211.

  42. D'Silva M, Gittes RF, Wolf P, Pirenne J, Munger K, Pascual J, et al. Rat kidney transplantation update with special reference to vesical calculi. Microsurgery 1990;11:169-176.

  43. Sheikh NM, Philen RM, Love LA. Chaparral-associated hepatotoxicity. Arch Intern Med 1997; 157:913-919.

  44. Smith AY, Feddersen RM, Gardner KD, Davis CJ. Cystic renal cell carcinoma and acquired renal cystic disease associated with consumption of chaparral tea: a case report. J Urol 1994;152(6 pt 1):2089-2091.

  45. Pittler MH, Ernst E. Systematic review: hepatotoxic events associated with herbal medicinal products. Aliment Pharmacol Ther 2003;18:451-471.

  46. Stedman C. Herbal hepatotoxicity. Semin Liver Dis 2002;22(2):2002.

  47. Brent J. Three new herbal hepatotoxic syndromes. Clin Toxicol 1999;37(6):715-719.

  48. Steenkamp V, Stewart MJ. Nephrotoxicity associated with exposure to plant toxins, with particular reference to Africa. Ther Drug Monit 2005; 27(3):270-277.

  49. Alderman S, Kailas S, Goldfarb S, Singaram C, Malone DG, et al. Cholestatic hepatitis after ingestion of chaparral leaf: confirmation by endoscopic retrograde cholangiopancreatography and liver biopsy. J Clin Gastroenterol 1994;19:242-247.

  50. Lambert JD, Zhao D, Meyers RO, Kuester RK, Timmermann BN, Dorr RT. Nordihydroguaiaretic acid: hepatotoxicity and detoxification in the mouse. Toxicon 2002;40(12):1701-1708.

  51. Sorensen JS, Heward E, Dearing MD. Plant secondary metobolites alter the feeding patterns of mammalian herbivore (Neotoma lepida). Oecologia 2005;146(3):415-422.

  52. Travis CC, White RK, Ward RC. Interspecies extrapolation of pharmacokinetics. J Theor Biol 1990; 142:285-304.

  53. Obermeyer WR, Musser SM, Betz JM, Casey RE, Pohland AE, Page SW. Chemical studies of phytoestrogens and related compounds in dietary supplements: flax and chaparral (43824). Proc Soc Exp Biol Med 1995;208:6-12.

  54. Heron S, Yarnell E. The safety of low-dose Larrea tridentata (DC) Coville (creosote bush or chaparral): a retrospective clinical study. J Altern Complement Med 2001;7(2):175-185.

  55. Milroy E. An experimental study of the calcification and absorption of polyglycolic acid and catgut sutures within the urinary tract. Invest Urol 1976;14(2):141-142.

  56. Verástegui MA, Sánchez CA, Heredia NL, García-Alvarado JS. Antimicrobial activity of extracts of three major plants from the Chihuahuan desert. J Ethnopharmacol 1996;52:175-177.




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