Sánchez-Ávila D, Granados-Romero JJ, Martínez G, Estrada-León F

Language: Spanish
References: 18
Page: 172-177
PDF size: 87.98 Kb.

ABSTRACT

Ocasionally there is abrupt change in the curse of an illness; the cancer present for many years without progression an in invasion shows quick growth. In general this was associated to biological changes from the same tumor and histologic changes in the origin the of original carcinoma to the transformation carcinoma indiference. This reports the case of one patient with thyroid neoplasms and biopsy report papillary carcinoma. In the transoperatory period, the report presents thyroid tumoration that displaces the tracheal to the right, approximately 4 cm. We did a tumorectomy with a sacrifice form the left recurrent laryngeal nerve, cervical esofagectomy, tracheostomy, and stamm-stype gastrostomy. The patology report of the surgery was anaplasic tumor of thyroid with follicular pattern that invaded the capsule. The surgical treatment of this kind of tumor presents different natures and this kind of tumor is so invasive frequently that they invalue critical sites. The patient, the subject of this report, is an example of histologic transformation of papillary carcinoma to thyroid anaplasic carcinoma, previously documented by of then authors. The co-existence of carcinomas-some well differentiated and others not differentiated-with transitional microscopic changes, together with an abrupt change in the clinical course, supports the concept of progression from well differentiated carcinomas.

REFERENCES

1. Crile G Jr, Wilson D. Transformation of low grade papillary carcinoma of the thyroid and anaplasic carcinoma after treatment with radioiodine. Surg Gynecol Obst 1959; 108: 357-360.

2. Frazell E, Foote F. Papillary cancer of the thyroid a review of 25 years of experience. Cancer 1958; 11: 895-922.

3. Hutter R, Tollefsen H, DeCosse J, Foote F Jr, Frazell E. Spindle and giant cell metaplasia in papillary carcinoma the thyroid. Am J Surg 1965; 110: 660-668.

4. Tanekazu H, Junihiko I, Katsutaro S, Yasuhiro H, Kazuhiro Y. Cancer 1997; 39: 2588-2596.

5. Nel C, Van Heerden J, Goellner J, Gharib H, McCohaney W, Taylor W, Grant C. Mayo Clinic Proc 1985; 60: 51-58

6. Loh K, Greenspan F, Gee L, Miller T, Yeo P. Clin Endocrinol Metabol 1997; 82: 3553-3562.

7. Jaffe R. Epithelial metaplasia of the thyroid gland. Arch Pathol 1937; 23: 821-850.

8. Hermann M, Kober F, Hollinsky C, Heiss A. Reinterventions in anaplasic cancers and sarcomas of the thyroid gland. Wiew Klin Wochenschr 1990; 102: 260-264.

9. Tan RK, Finley RK, Driscoll D. Anaplasic carcinoma of the thyroid a 24 year experience. Head Neck 1996; 18: 36-41.

10. Kobayashi T, Asakawa H, Umeshita K. Treatment of 37 patients with anaplasic carcinoma of the thyroid head neck 1996; 18: 36-41.

11. Levendag PC, De Porre PM, Van Putten WL. Anaplasic carcinoma of the thyroid gland treated by radiation therapy. Int J Radiat Oncol Biol Phys 1993; 26: 125-128.

12. Kim JH, Tleeper RD. Treatment of locally advanced thyroid carcinoma with combination dexerrubicin and radiation therapy. Cancer 1987; 60: 2372-2375.

13. Kim JH, Leeper RD. Treatment of anaplasic giant and spindle cell carcinoma of the thyroid gland with combination adriamycin and radiation therapy. Cancer 1983; 52: 954-957.

14. Tenvall J, Lundell G, Hallquist A, Wahlberg P, Wallin G, Tibblin S. Combined doxorubicin, hyperfractionated radiotherapy, and surgery in anaplasic thyroid carcinoma. Cancer 1994; 74: 1348-1354.

15. Asakawa H, L Kobayashi T, Komoike Y, Wakasugi E, Maruyama H, Tamaki Y, Matasuzawa Y, Monden M. Establishment of anaplasic thyroid carcinoma cell lines useful for analysis of chemosensitivy and carcinogenesis. Clin Endocrinol Metabol 1996; 81: 3547-3552.

16. Blagosklonny M, Giannakakou P, Wajtowicz M, Romanava L, Ain K, Bates S. Effects pf p-53 expresing adenovirus on the chemosensitivy and differentiation of anaplasic thyroid cancer cellss. Clin Endocrinol Metabol 1998; 83: 2516-2522.

17. Gillenwater A, Goepfert H. Surgical management of laryngotracheal and esophageal involvement by locally advanced thyroid cancer. Semin Surg Oncol 1999; 16: 19-29.

18. Arscott P, Stoker T, Myc A, Giordano T, Thompson N, Baker J. Fas (CD 95) expression is up-regulated in papillary thyroid carcinoma 1999; 84: 4246-4252.