medigraphic.com

2000, Number 4

<< Back Next >>

Cir Cir 2000; 68 (4)

Probable genetic background in acute appendicitis

Gamboa-Ojeda IA, Vázquez-Benítez A, Lorenzana-Merlín E, Sánchez-Cuautle MSL

Language: Spanish
References: 24
Page: 148-153
PDF size: 65.94 Kb.


ABSTRACT

Objective: To determine the existence of possible genetic factors in acute appendicitis with only the genealogic tree as an instrument. Material and methods: On 108 pedigrees taking as propositos 56 women and 52 adult males, physicians, medical students or individuals from the general population who accepted to answer the questionnaire, we know whether their first-degree relatives (parents or siblings) were or were not appendicectomized. Results: Six propositos answered affirmatively (5.55%) and 102 (94.45%) answered negatively. The first group had 37 first-degree relatives and the second group had 437, with eight and 32 appendicectomized individuals among them, respectively. Chi square test had a value of 9.874 (p ‹ 0.002). Conclusions: Despite many biases such as memory, the special answered type, the lacks of pathology studies in certain cases, the chi square value founded reinforced the idea that probably it exists some genetic factors in acute appendicitis. Perhaps the highest risk for a first-degree relative to acquire the infectious could be as high as 25%, but it is necessary for more epidemiological surveys to improve the accuracy. Inheritance model more adjusted to acute appendicitis is the multifactorial one.


REFERENCES

  1. Silen W. Acute appendicitis. In: Harrison’s principles of internal medicine. 13th ed. Ed McGraw Hill; 1994: p. 1433-5.

  2. Vargas Domínguez A, Ortega León LH, Miranda Fraga P. Utilidad de la clínica en el diagnóstico de apendicitis. 1995; 63: 93-6.

  3. Martínez-De Jesús FR, Gallardo Hernández R, Morales Guzmán M, Pérez Moralez A. Retardo en la hospitalización, el diagnóstico y la intervención quirúrgica de la apendicitis aguda. Rev Gastroenterol Mex 1995; 60: 17-21.

  4. Baeza Herrera C, Guido Ramírez O, González Galicia JA, Rojas Aro E. Apendicitis en niños menores de tres años. Rev Gastroenterol Mex 1994; 59-3.

  5. García-Murray OJ, García-Murray E, García-Pérez O, López Zendejas G, Vazquez del Mercado CR. Evaluación de 100 apendicectomías en un hospital pediátrico privado. Rev Mex Pericult y Pediatr 1997; 25: 32-6.

  6. García-García D, Hernández-Suárez JF. Apendicitis aguda perforada: signos radiológicos. Rev Mex Radiol 1995; 49: 139-41.

  7. Ortega León LH, Vargas Domínguez A, Miranda Fraga P. Complicaciones locales de la apendicitis. Rev Gastroenterol Mex 1994; 59.

  8. Eriksson S, Josephson T, Styrud J. A high degree of accuracy is possible in the diagnosis of appendicitis. Laboratory test, ultrasonography and computerized tomography are of great value. Lakartidningen 1999; 96: 3058-61.

  9. Hee P, Viktrup L. The diagnosis of appendicitis during pregnancy and maternal and fetal: outcome after appendectomy. Int J Gynaecol Obstet 1999; 65: 129:35

  10. Di Sebastiano P, Kink T, di Mola FF, Weihe E, Innocenti P, Friess H, Buchler MW. Neuroimmune appendicitis. Lancet 1999; 354: 461-6.

  11. Poon RT, Chu KW. Inflammatory cecal masses in patients presenting with appendicitis. World J Surg 1999; 7: 713-6 (discussion 716).

  12. del Río Martín JV, Ashraf Memon M. La justificación para apendicectomía laparoscópica. Rev Esp Enferm Diag 1999; 91: 447-55.

  13. Van Glabeke E, Larroquet M, Khairouni A, Audry G, Grapin C, Gruner M. Treatment of appendiceal peritonitis in Jildren by video laparoscopic conversion. Jirurgie 1999; 124: 304-6.

  14. Strassnann V, Velhote MC, Santoro S, Malzoni CE, Klajner S, Borges PC. Laparoscopy appendicectomy with linear stapler. Rev Hosp Clin Fac Med Sao Paulo 1998; 53: 230-3.

  15. Nguyen DB, Silen W, Hodin RA. Appendectomy in the pre- and postlaparoscopic eras. J Gastrointest Surg 1999; 3: 67-73.

  16. Bergeron E, Richer B, Gharib R, Giard A. Appendicitis is a place for clinical judgement. Am J Surg 1999; 177: 460-2.

  17. Fujiwara H, Nomura H, Yasuda K, Kuroda D, Kato M, Ohyanagi H, Acute appendicitis complicated with necrotizing soft tissue infections in the elderly: report of a case. Hepatogastroenterology 1999; 46: 1702-5.

  18. Kraemer M, Kremer K, Leppert R, Yang Q, Ohmann C, Fuchs KH. Perforating appendicitis: is it a separate disease? Acute Abdominal Pain Study Group. Eur J Surg 1999; 165: 473-80.

  19. Kokoska ER, Silen ML, Tracy TF Jr, Dillon PA, Kennedy DJ, Cradock TV, Weber TR. The impact of intraoperative culture on treatment and outcome in Jildren with perforated appendicitis. J Pediatr Surg 1999; 34: 749-53.

  20. McKusick VA. Appendicitis. In: Mendelian inheritance in man. 12th ed. Baltimore, MA, USA: John Hopkins Medical University Press; 1998: p. 172.

  21. Baker EGS. A family pedigree for appendicitis. J Hered 1937; 28: 187-91.

  22. Basta N, Morton BE, Mulvihill JJ, Radovanovic A, Radojicic C, Marinkovic D. Inheritance of acute appendicitis: familial aggregation and evidence of polygenic transmission. Am J Hum Genet 1990; 46: 377-82.

  23. Shamis I, Livshitz G, Feldman U. Ethnicity and familial factors in the etiology of acute appendicitis. Am J Hum Biol 1994; 6: 351-8.

  24. Feinstein A. Retrospective case-control (Trohoc) studies. In: Clinical epidemiology. The arJitecture of clinical research. WB Saunders Company; 1985: pp. 533-6.




2020     |     www.medigraphic.com