2012, Number 1
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Bol Med Hosp Infant Mex 2012; 69 (1)
Acute pancreatitis
Sánchez AC, García AJA
Language: Spanish
References: 34
Page: 3-10
PDF size: 300.83 Kb.
ABSTRACT
Suspicion of acute pancreatitis must arise with abdominal pain and oral food intolerance. This mainly occurs in a patient who has undergone abdominal trauma or presents an underlying systemic disease with an added infection, vascular or hemodynamic component, or if the patient is receiving multiple drugs. Apparently healthy children ‹4 years of age can display pancreatitis as a result of congenital alterations that favor the condition such as pancreas divisum and metabolic or hereditary diseases, emphasizing that the latter are related to recurrent or chronic pancreatitis. Diagnosis must be confirmed with pancreatic enzyme determination and an imaging study such as abdominal tomography or magnetic resonance. Immediate treatment is aimed at support, maintaining an appropriate hydration state and metabolic balance in addition to avoiding pancreatic stimulation through fasting and gastric decompression. In serious cases, the evolution tends to be prolonged. For this reason, in addition to these measures, opportune nutritional support must be instituted through parenteral nutrition or by enteral nutrition with nasojejunal catheter. Finally, it is indispensable to detect and to opportunely treat complications like pancreatic necrosis, secondary infection and multiple organ failure.
REFERENCES
Nydegger A, Couper RTL, Olive MR. Childhood pancreatitis. J Gastroenterol Hepatol 2006;21:499-509.
Vega-Franco L, García-Aranda JA, Meza-Camacho C, González R. Pancreatitis en niños lactantes con diagnóstico clínico de septicemia. Bol Med Hosp Infant Mex 1981;38:131-142.
Benifla M, Weizman ZJ. Acute pancreatitis in childhood: analysis of literature data. J Clin Gastroenterol 2003;37:169-172.
Kandula L, Lowe ME. Etiology and outcome of acute pancreatitis in infants and toddlers. J Pediatr 2008;152:106-110.
Sibert JR. Pancreatitis in children. A study in the North of England. Arch Dis Child 1975;50:443-448.
Katschinski BD, Giggs JA, Bourke JB. Incidence and geographical distribution of acute pancreatitis in Nottingham 1969 to 1983. Z Gastroenterology 1990;28:183-187.
Hirohashi S, Hirohashi R, Uchida H, Akira M, Itoh T, Haku E, et al. Pancreatitis: evaluation with MR cholangiopancreatography in children. Radiology 1997;203:411-415.
Park A, Latif SU, Shah AU, Tian J, Werlin S, Hsiao A, et al. Changing referral trends of acute pancreatitis in children: a 12-year single-center analysis. J Pediatr Gastroenterol Nutr 2009;49:316-322.
Rojas PNA, Márquez ELM, Flores CJ. Pancreatitis necróticohemorrágica en niños. Resúmenes de la XII reunión de investigación, Hospital de Pediatría del Centro Médico Nacional SXXI, Instituto Mexicano del Seguro Social; 12, 13 y 14 de febrero de 1992. Parte II. Bol Med Hosp Infant Mex 1992;49:718.
Datos del Departamento de Bioestadística del Hospital Infantil de México Federico Gómez; 2008.
Jackson WD. Pancreatitis: etiology, diagnosis, and management. Curr Opin Pediatr 2001;13:447-451.
Bhagat S, Wadhawan M, Sud R, Arora A. Hepatitis viruses causing pancreatitis and hepatitis: a case series and review of literature. Pancreas 2008;36:424-427.
Knoderer HM, Robarge J, Flockhart DA. Predicting asparaginase-associated pancreatitis. Pediatr Blood Cancer 2007;49:634-639.
Akel S, Khalifeh M, Makhlouf Akel M. Gallstone pancreatitis in children: atypical presentation and review. Eur J Pediatr 2005;164:482-485.
Weber CK, Adler G. From acinar cell damage to systemic inflammatory response: current concepts in pancreatitis. Pancreatology 2001;1:356-362.
Saluja AK, Steer MLP. Pathophysiology of pancreatitis. Role of cytokines and other mediators of inflammation. Digestion1999;60(suppl 1):27-33.
Lerner A, Branski D, Lebenthal E. Pancreatic diseases in children. Pediatr Clin North Am 1996;43:125-156.
Whitcomb DC, Gorry MC, Preston RA, Furey W, Sossenheimer MJ, Ulrich CD, et al. Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene. Nat Genet 1996;14:141-145.
Pfützer RH, Barmada MM, Brunskill AP, Finch R, Hart PS, Neoptolemos J, et al. SPINK1/PSTI polymorphisms act as disease modifiers in familial and idiopathic chronic pancreatitis. Gastroenterology 2000;119:615-623.
Threadgold J, Greenhalf W, Ellis I, Howes N, Lerch MM, Simon P, et al. The N34S mutation of SPINK1 (PSTI) is associated with a familial pattern of idiopathic chronic pancreatitis but does not cause the disease. Gut 2002;50:675-681.
Haddock G, Coupar G, Youngson GG, MacKinlay GA, Paine PA. Acute pancreatitis in children: a 15-year review. J Pediatr Surg 1994;29:719-722.
Whitcomb DC, Lowe ME. Pancreatitis. Acute and chronic. En: Walker WA, Goulet O, Kleinman RE, Sherman PM, Shneider BL, Sanderson IR, eds. Pediatric Gastrointestinal Disease. Pathophysiology, Diagnosis, and Management. Ontario, BC: Decker; 2004. pp. 1584-1597.
Frank B, Gottlieb K. Amylase normal, lipase elevated: is it pancreatitis? A case series and review of the literature. Am J Gastroenterol 1999;94:463-469.
Muddana V, Whitcomb DC, Khalid A, Slivka A, Papachristou GI. Elevated serum creatinine as a marker of pan creatic necrosis in acute pancreatitis. Am J Gastroenterol 2009;104:164-170.
Elmas N. The role of diagnostic radiology in pancreatitis. Eur J Radiol 2001;38:120-132.
Darge K, Anupindi S. Pancreatitis and the role of US, MRCP and ERCP. Pediatr Radiol 2009;39(suppl 2):S153-S157.
Vaughn DD, Jabra AA, Fishman EK. Pancreatic disease in children and young adults: evaluation with CT. Radiographics 1998;18:1171-1187.
Nijs E, Callahan MJ, Taylor GA. Disorders of the pediatric pancreas: imaging features. Pediatr Radiol 2005;35:358-373.
Andriulli A, Leandro G, Clemente R, Festa V, Caruso N, Annese V, et al. Meta-analysis of somatostatin, octreotide and gabexate mesilate in the therapy of acute pancreatitis. Aliment Pharmacol Ther 1998;12:237-245.
Marik PE, Zaloga GP. Meta-analysis of parenteral nutrition versus enteral nutrition in patients with acute pancreatitis. BMJ 2004;328:1407. doi:10.1136/bmj.38118.593900.55
Jiang K, Chen XZ, Xia Q, Tang WF, Wang L. Early nasogastric enteral nutrition for severe acute pancreatitis: a systematic review. World J Gastroenterol 2007;13:5253-5260.
Doley RP, Yadav TD, Wig JD, Kochhar R, Singh G, Bharathy KG, et al. Enteral nutrition in severe acute pancreatitis. J Pancreas 2009;10:157-162.
Büchler MW, Gloor B, Müller CA, Friess H, Seiler CA, Uhl W. Acute necrotizing pancreatitis: treatment strategy according to the status of infection. Ann Surg 2000;232:619-626.
Spraker HL, Spyridis GP, Pui CH, Howard SC. Conservative management of pancreatic pseudocysts in children with acute lymphoblastic leukemia. J Pediatr Hematol Oncol 2009;31:957-959.