2012, Number 1
<< Back Next >>
Enf Infec Microbiol 2012; 32 (1)
Analysis of an outbreak of Candida albicans in the Newborn Unit of Civil Hospital Fray Antonio Alcalde in Guadalajara, Mexico
Becerra G, Rivera MC, Kimble PEL, Plascencia HA, Sánchez GRA, Hernández CII
Language: Spanish
References: 14
Page: 11-14
PDF size: 222.82 Kb.
ABSTRACT
The genus
Candida is involved in different pathological processes in intrahospitalary infections. Development of diagnostic methods has made possible isolation, identification and monitoring of genus
Candida. The purpose of this study was to describe a
Candida albicans outbreak at the Newborn Unit.
Methods. Three clinical cases were described by a mycological and molecular study in order to identify the microorganism and obtain a correct diagnosis of the yeast isolated from blood culture.
Results. The
Candida albicans were phenotypically and genotypically identified. We evaluated the clinical cases and identified the risk factors associated to the outbreak.
Conclusion. The risk factors of transmission were use of broad spectrum antibacterial agents and use of intravenous catheters.
REFERENCES
Kossoff E H, Buescher E S, Karlowicz M G 1998. “Candidemia in a neonatal intensive care unit: trends during fifteen years and clinical features of 111 cases”. Pediatr Infect Dis J 7:504–508.
Saiman L, Ludington E, Dawson JD, Patterson JE, Rangel-Frausto S, Wiblin RT, Blumberg HM, Pfaller M, Rinaldi M, Edwards JE, Wenzel RP, Jarvis W 2001. “Risk factors for Candida species colonization of neonatal intensive care unit patients”. Pediatr Infect Dis J 20:1119–1124.
Baron EJ, Landry ML, Jorgensen JH y Pfaller MA 2007. Murray PR. Manual of clinical microbiology. 9a ed. Vol. II, ASM Press, Washington, p. 2256.
Filler SG, y Sheppard DC 2006. « Fungal Invasion of normally non-phagocytic host cells”. PLoS Pathog 2: 129.
Diekema DJ, Pfaller MA, Jones RN, Doern GV, Kugler KC, Beach ML, Sader HS 2000. “Trends in antimicrobial susceptibility of bacterial pathogens isolated from patients with blood stream infections in the USA, Canada, and Latin America SENTRY Participants Group”. Int J Antimicrob Agents 13:257–271.
Tortorano AM, Kibbler C, Peman J, Bernhardt H, Klingspor L, Grillot R 2006. “Candidaemia in Europe: epidemiology and resistance”. Int J Antimicrob Agents 27: 359-366.
Swinne D, Watelle M, Van der Flaes M, Nolard N 2004. “In vitro activities of voriconazole (UK-109, 496), fluconazole, itraconazole and amphotericin B against 132 non-albicans bloodstream yeast isolates (CANARI study)”. Mycoses 47:177-83.
Pfaller M A, Jones R N, Doern GV, Sader HS, Messer SA, Houston A, Coffman S, Hollis RJ 2000. “Bloodstream infections due to Candida species: SENTRY Antimicrobial Surveillance Program in North America and Latin America, 1997–1998”. Antimicrob Agents Chemother 44:747–751.
Godoy P, Tiraboschi IN, Severo LC, Bustamante B, Calvo B, Almeida LP, da Matta DA, Colombo AL 2003. “Species distribution and antifungal susceptibility profile of Candida spp. Bloodstream isolates from latin american hospitals”. Mem Inst Oswaldo Cruz 98: 401-405.
Bautista-Muñoz C, Boldo XM, Villa-Tanaca L, Hernández-Rodríguez C 2003. “Identification of Candida spp. by randomly amplified polymorphic DNA analysis and differentiation between Candida albicans and Candida dubliniensis by direct PCR methods”. J Clin Microbio 41:414-20.
Olivas-Escárcega V, Rui-Rodríguez MS, Fonseca-Leal MP, Santos-Díaz MA, Gordillo-Moscoso A, Nernández- Sierra JF, de J Pozos-Guillén A. 2008. “Prevalence of oral candidiasis in chronic renal failure and renal transplant pediatric patients”. J Clin Pediatr Dent 32:313-317.
Fujita SI, Senda Y, Nakaguchi S, Hashimoto T 2001. “Multiplex PCR Using Internal Transcribed Spacer 1 and 2 Regions for Rapid Detection and Identification of Yeast Strains”. J Clin Microbiol 39: 3617–3622.
Schelonka RL, Infante AJ 1998. “Neonatal immunology”. Semin Perinatol 22:2-14.
Damjanovic V, Connolly CM, van Saene HK, Cooke RW, Corkill JE, van Belkum A, van Velzen D 1993. “Selective decontamination with nystatin for control of a Candida outbreak in a neonatal intensive care unit”. J Hosp Infect 24: 245-259.