2012, Number 1
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Rev Mex Urol 2012; 72 (1)
Chronic kidney failure frequency and associated factors in kidney cancer patients having undergone nephrectomy
García-Salcido FJ, Santana-Rios Z, Urdiales-Ortiz A, Fulda-Graue S, Pérez-Becerra R, Fernández-Noyola G, Martínez JA, Ahumada-Tamayo S, Camacho-Castro A, Muñoz-Ibarra EL, Osornio-Sánchez V, Mayorga-Gómez E, Garza-Saenz G, Martínez-Arroyo C, Cantellano-Orozco M, Morales-Montor G, Pacheco-Gahbler C
Language: Spanish
References: 14
Page: 3-7
PDF size: 431.01 Kb.
ABSTRACT
Introduction: For many years radical nephrectomy has been the treatment of choice in kidney tumor management. Currently nephron-sparing surgery in T1 tumors is the indicated therapy. Patients with kidney cancer are at risk for developing chronic kidney failure after surgical treatment when presenting with risk factors such as diabetes, high blood pressure, obesity, and smoking.
Objective: To determine the presence of chronic kidney failure and associated factors involved in its development in patients having undergone partial or radical nephrectomy due to kidney cancer.
Material and methods: The variables of sex, body mass index, diabetes mellitus, high blood pressure, smoking, and preoperative and postoperative kidney function were analyzed in fifty-two patients having undergone partial or radical nephrectomy over a five-year period. Patients with preoperative kidney damage were excluded.
Results: Forty-seven patients fit the inclusion criteria, fortythree underwent radical nephrectomy, four underwent partial nephrectomy, eleven presented with diabetes mellitus, twenty-five presented with high blood pressure, and nineteen patients were smokers. Of the radical nephrectomy patients, eleven (23%) developed chronic kidney damage. No patient having undergone partial nephrectomy developed kidney damage.
Conclusions: Patients undergoing partial or radical nephrectomy are at greater risk for developing chronic kidney damage, regardless of other risk factors.
REFERENCES
Mckiernan J, Simmons R, Katz J, et al. Natural History of Chronic Renal Insufficiency After Partial and Radical Nephrectomy. Urology 2002;59:816-820.
Russo P. Renal cell carcinoma: presentation, staging, and surgical treatment. Semin Oncol 2000;27:160-176.
Zini L, Perrote P, Capitanio U, et al. Radical versus Partial Nephrectomy. Effects on overall and noncancer mortality. Cancer 2009;115:1465-1471.
Huang WC, Levey AS, Serio AM, et al. Chronic kidney disease after nephrectomy in patients with renal cortical tumours: a retrospective cohort study. Lancet Oncol 2006;7:735-740.
Riehle RA Jr, Steckler R, Naslund EB, et al. Selection criteria for the evaluation of living related renal donors. J Urol 1990;144:845-848.
Pettus JA, Jang TL, Thompson RH, Yossepowitch O, Kagiwada M, Russo P. Effect of baseline glomerular filtration rate on survival in patients undergoing partial or radical nephrectomy for renal cortical tumors. Mayo Clin Proc. 2008 Oct; 83(10):1101-6.
Pettus J, Jang TL, Thompson RH, et al. Baseline GFR Impacts Survival in Patients Undergoing Partial or Radical Nephrectomy for Renal Cortical Tumors. Mayo Clin Proc 2008;83:1101-1106.
Juan I, Puchades MJ, Solís MA, et al. Evolución de la Función Renal y Factores de Progresión en Pacientes Nefrectomizados. Nefrologia 2010;30:202-207.
Barlow LJ, Korets R, Laudano M, et al. Predicting Renal Functional Outcomes After surgery for Renal Cortical Tumours: A multifactorial analysis. BJU Int 2010;106:489-492.
Huang WC, Elkin EB, Levey AS, et al. Partial Nephrectomy Versus Radical Nephrectomy in Patients With Small Renal Tumors- Is There a Difference in Mortality and Cardiovascular Outcomes. J Urol 2009;181:55-61.
Sorbellini M, Kattan MW, Snyder ME, Hakimi AA, Sarasohn DM, Russo P. Prognostic monogram for renal insufficiency after radical or partial nephrectomy. J Urol. 2006 Aug; 176(2):472-6; discussion 476.
Karim Touijer, Didier Jacqmin, Louis R, et al. The Expanding Role of Partial Nephrectomy: A Critical Analysis of Indications, Results, and Complications. Eur Urol 2010;57:214-222.
Klarenbach S, Moore RB, Chapman DW, et al. Adverse renal outcomes in subjects undergoing nephrectomy for renal tumors: a population-based analysis. Eur Urol 2011;59:333-339.
Jeon HG, Jeong IG, Lee JW, et al. Prognostic Factors for Chronic Kidney Disease After Curative Surgery in Patients with Small Renal Tumors. Urology 2009;74:1064-1068.