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Boletín Médico del Hospital Infantil de México

2011, Number 4

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Bol Med Hosp Infant Mex 2011; 68 (4)

Infantile myofibromatosis: case report and literature review

Fasola MML, Manfrin L, Galluzo ML, Vilma SA

Language: Spanish
References: 24
Page: 296-301
PDF size: 378.49 Kb.


ABSTRACT

Background. Infantile myofibromatosis (IM) is a disease characterized by solitary or multiple benign tumors. The etiology is unknown. IM is a benign mesenchymal disorder of early infancy and is more frequent in males. IM may present in two manners: as a solitary lesion most commonly in skin, bone, muscle, subcutaneous tissue, in head, neck and trunk, with good prognosis, or a multicentric form of IM with or without visceral involvement (heart, lung, gastrointestinal tract, kidney) with a poor prognosis. The definitive diagnosis of IM is confirmed by pathology. Treatment may be conservative (observation with close follow-up) or surgery (solitary form) or chemotherapy (visceral form).
Case report. We report a case of a 16-months-old male patient with left neck tumor diagnosed as IM. He was admitted into intensive care unit because of respiratory distress with stridor caused by tumor compression. Mechanical ventilation was required by the patient who underwent surgery to resect the tumor. The patient had a favorable postoperative evolution.
Conclusions. IM must be considered in the differential diagnosis of tumors in early infancy, despite its low frequency. Treatment and prognosis depend on location, clinical form (solitary or multicentric), with or without visceral involvement.


REFERENCES

  1. Scheper MA, DiFabio VE, Sauk JJ, Nikitakis NG. Myofibromatosis: a case report with a unique clinical presentation. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2005;99:325-330.

  2. Pelluard-Nehmé F, Coatleven F, Carles D, Alberti EM, Briex M, Dallay D. Multicentric infantile myofibromatosis: two perinatal cases. Eur J Pediatr 2007;166:997-1001.

  3. Stout AP. Juvenile fibromatoses. Cancer 1954;7:953-978.

  4. Chung EB, Enzinger FM. Infantile myofibromatosis. Cancer 1981;48:1807-1818.

  5. Smith KJ, Skelton HG, Barrett TL, Lupton GP, Graham JH. Cutaneous myofibroma. Mod Pathol 1989;2:603-609.

  6. Daimaru Y, Hashimoto H, Enjoji M. Myofibromatosis in adults (adult counterpart of infantile myofibromatosis). Am J Surg Pathol 1989;13:859-865.

  7. Rubin BP, Bridge JA. Myofibroma/Myofibromatosis. En: Fletcher CDM, Unni KK, Mertens F, eds. World Health Organization Classification of Tumors. Pathology and Genetics of Tumors of Soft Tissue and Bone. Lyon: IARC Press; 2002. pp. 59-61. Disponible en: http://www.iarc.fr/en/publications/pdfs-online/pat-gen/bb5/BB5.pdf

  8. Franzese CB, Carron J. Infantile myofibromatosis: unusual diagnosis in an older child. Int J Pediatr Otorhinolaryngol 2005;69:865-868.

  9. Kaplan SS, Ojemann JG, Grange DK, Fuller C, Park TS. Intracranial infantile myofibromatosis with intraparenchymal involvement. Pediatr Neurosurg 2002;36;214-217.

  10. Wiswell TE, Davis J, Cunningham BE, Solenberger R, Thomas PJ. Infantile myofibromatosis: the most common fibrous tumor of infancy. J Pediatr Surg 1988;23:314-318.

  11. Muraoka I, Ohno Y, Kamitamari A, Okada M, Moriuchi H, Kanematsu T. Congenital occurrence of solitary infantile myofibromatosis of the spleen. J Pediatr Surg 2008;43:227-230.

  12. Stanford D, Rogers M. Dermatological presentations of infantile myofibromatosis: a review of 27 cases. Australas J Derm 2000;41:156-161.

  13. Prado Calleros HM, Castillo Ventura BB, Arrieta Gómez JR, García García MA, Sánchez Marín LA, et al. Tumores fibrosos/ miofibrosos en cabeza y cuello. Rev Hosp Gral Dr. M Gea González 2006;7:76-81.

  14. Rohrer K, Murphy R, Thresher C, Jacir N, Bergman K. Infantile myofibromatosis: a most unusual cause of gastric outlet obstruction. Pediatr Radiol 2005;35:808-811.

  15. Spadola L, Anooshiravani M, Sayegh Y, Jéquier S, Hanquinet S. Generalised infantile myofibromatosis with intracranial involvement: imaging findings in a newborn. Pediatr Radiol 2002;32:872-874.

  16. Short M, Dramis A, Ramani P, Parikh DH. Mediastinal and pulmonary infantile myofibromatosis: an unusual surgical presentation. J Pediatr Surg 2008;43:e29-e31.

  17. Hermida-Pérez JA, Ochoa-Montes de Oca J, Ochoa-Urdangararain O, Bastian-Manso L, Morell-Molina E. Miofibromatosis infantil. Su relación con el aparato genitourinario. Presentación de un caso y revisión de la literatura. Arch Esp Urol 2007;60:571-576.

  18. Okay O, Kulacoglu S, Ergungor MF, Secer M, Han O, Dalgic A. An unusual mesenchymal tumor of the skull: infantile myofibromatosis. Pediatr Neurosurg 2008;44:178-180.

  19. Rossbach C, Tannapfel A, Troebs RB, Hirsh W, Koerholz D. Successful treatment of relapsed multifocal nonvisceral infantile myofibromatosis. Pediatr Hematol Oncol 2005;22:695-698.

  20. Hyun Yoo J, Naeini RM, Hunter JV. Infantile myofibromatosis involving the choroid plexus. Pediatr Radiol 2008;38:107-110.

  21. Chapman P, Judd CD, Felgenhauer JL, Gruber DP, Mornin D. Infantile myofibromatosis of the posterior fossa. Am J Roentgenol 2005;184:1310-1312.

  22. Tamburrini G, Gessi M, Colosimo C Jr, Lauriola L, Giangaspero F, Di Rocco C. Infantile myofibromatosis of the central nervous system. Childs Nerv Syst 2003;19:650-654.

  23. Day M, Edwards AO, Weinberg A, Leavey PJ. Brief report: successful therapy of a patient with infantile generalized myofibromatosis. Med Pediatr Oncol 2002;38:371-373.

  24. Williams W, Craver RD, Correa H, Velez M, Gardner RV. Use of 2-chlorodeoxyadenosine to treat infantile myofibromatosis. J Pediatr Hematol Oncol 2002;24:59-63.




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