medigraphic.com
Órgano Ofical de la Facultad de Estomatología de la Benemérita Universidad Autónoma de Puebla

2010, Number 33

<< Back Next >>

Oral 2010; 11 (33)

Minocyclina gel efectivity in the periodontal therapy

Castillo BKJ, Guerrero ÁF, Torres BJM, Cortazar AC, Vilches AR, Téllez JH

Language: Spanish
References: 31
Page: 557-560
PDF size: 112.28 Kb.


ABSTRACT

Objetive. Evaluate the clinical effectiveness of local topic minocycline on periodontal therapy.
Introduction. Antibiotics are just an alternative treatment when conventional periodontal therapy is not enough to obtain the spected results. Establish adequated dosification and concentration on topic form is necessary to achieve a maximum therapeutic benefit. Hydrochlorate Minocycline on gel presentation has a high endurance, liposubility, broad-spectrum, minor phototoxity and anti-inflammatory effect, also inhibits bone resorption, prostaglandins synthesis and reduces the gingival index and probing depth.
Methods. Eighteen patients between 27 to 66 years old systemically healthy, both genders, that presented moderated to advanced chronic periodontal disease, with a probing depth of ›4mm. Two measurements were made first at the patients check-in, and the last after 21 days.
Results. 221 dentary organs were analyzed with an observed reduction of plaque index of 62% at the beginning and 23% after 21 days also a reduction of bleeding on probing index from 94% to 28% after 21 days. Pocket depth had a reduction on mesio and disto-vestibular as in mesio and disto-palatine sites.
Discussion. There were significant results on the climical parameters of the present study with a reliable reduction on plaque index, bleeding on probing index and pocket depth.


REFERENCES

  1. Brook I. Management and Prevention of Dental Infection. Medscape 2003.

  2. Feres-Filho EJ., et al. Treatment of chronic Periodontitis with systemic antibiotics only. Journal of Clinical Periodontology 2006; 33: 936-937.

  3. Choudhury, M., et. Systemic and local antimicrobial use in periodontal therapy in England and Wales. Journal of Clinical Periodontology 2001; 28: 833-839.

  4. Haffajee, A.D. Systemic antibiotics: to use or not to use in the treatment of periodontal infections. That is the question” Journal of Clinical Perio dontology 2006; 33: 359-361.

  5. Fonseca, A. Antimicrobianos de uso sistémico en la enfermedad periodontal. Odus Científica, 2004; Vol. V, No. 1.

  6. Kleinfelder, J.W., et. Antibiotic susceptibility of putative periodontal pathogens in advanced periodontitis patients”. Journal of Clinical Periodontology 1999; 26: 347-351.

  7. Awartani, F.A., et. Comparación de los efectos clínicos entre la aplicación subgingival de gel metronidazol al 25% y raspado en el tratamiento de la periodontitis del adulto. Quintessence, 1999; Vol. No. 1.

  8. LaPorta, V.N.J., et. (Minocycline- associated intra-oral soft-tissue pigmentation: clinicopathologic correlations and review. Journal of Clinical Periodontology, 2005; 32: 119-122.

  9. O'Connor, B.C., et. (Susceptibility and Resistance of Plaque Bacteria to Minocycline. Journal of Clinical Periodontology, 1990; Apr 228-233.

  10. Larsen, T., et. Development of resistance to metronidazole and minocycline in vitro. Journal of Clinical Periodontology, 1997; 24: 254-259.

  11. Silverstein, L., et. Clinical and Microbiologic Effects of Local Tetracycline Irrigation on Periodontitis. Journal of Clinical Periodontology 1988; May 301–305.

  12. Martínez, J., et. Efecto de la Minociclina como coadyuvante en el tratamiento de la Enfermedad Periodontal. Acta Odontológica Venezolana 2003; Vol. 41 No. 1.

  13. Graca, M.A., et. A randomized controlled trial of a 2% minocycline gel as an adjunct to non-surgical periodontal treatment, using a design with multiple matching criteria. Journal of Clinical Periodontology, 1997; 24:249-253.

  14. McColl, E., et. Supportive periodontal therapy using mechanical instrumentation or 2% minocycline gel: a 12 month randomized, controlled, single masked pilot study. Journal of Clinical Periodontology 2006; 33: 141-150.

  15. Radva, R.M., et. Comparison of 3 Periodontal Local Antibiotic Therapies in Persistent Periodontal Pockets. Journal of Clinical Periodontology, 1996; 860-865.

  16. Greentein, G. Clinical Significance of Bacterial Resistance to Tetracyclines in the Treatment of Periodontal Diseases. Journal of Clinical Periodontology, 1995; 925-932.

  17. Jones, A., et. Clinical and Microbiological Effects of Controlled-Release Locally Delivered Minocycline in Periodontitis. Journal of Clinical Periodontology ,1994; 1058-1066.

  18. Ciancio, S.G. Tissue Concentration and Localization of Tetracycline Following Site-Specific Tetracycline Fiber Therapy. Journal of Clinical Periodontology, 1992; 849-853.

  19. Ünsal, E., et. The Effect of a Single Application of Subgingival Antimicrobial or Mechanical Therapy on the Clinical Parameters of Juvenile Periodontitis. Journal of Clinical Periodontology, 1995; 47-51.

  20. Needleman, I.G.The Effect of 1% Metronidazole Gel in Routine Maintenance of Persistent Furcation Involvement in Human Beings. Journal of Clinical Periodontology, 1989; 699-703.

  21. Calderón, E.J. Aplicación Clínica de los Antibióticos y Quimioterapéuticos. Séptima Edición, 1997.

  22. Salazar, E., et. Rol de la Azitromicina en el tratamiento de Abscesos Periodontales. Facultad de Odontología; Universidad de Caracas Venezuela, 2001.

  23. Schenkein, H., et. The Pathogenesis of Periodontal Diseases. Journal of Clinical Periodontology, 1999; 70:457-470.

  24. Salazar, E.P. Rol de la Azitromicina en el tratamiento de abscesos periodontales. Revista Odontológica UCV, Febrero, 2001.

  25. Committee on Research, Sciencie and Therapy, A.A.P. The potencial Role of Controlled-Release Chemotherapy for Periodontitis,1994.

  26. Lindhe, J.,et.Periodontología Clínica e Implantología Odontológica, 4ª. Edición.

  27. Carranza, F., et. Periodontología Clínica. 9ª. Edición.

  28. Slots, J., et. Systemic Antibiotics in Periodontics, Journal of Clinical Periodontology, 1996 Ago (831-838).

  29. Genco, R., et. Antibiotics in the Treatment of Human Periodontal Diseases. Journal of Clinical Periodontology, 1981 Sep (545-558).

  30. Holroyd S., et. “(Antibiotics in the Practice of the Periodontics” Journal of Clinical Periodontology 1971 Sep (584-589).

  31. Bascones, A., et. Documento de consenso sobre el tratamiento antimicrobiano de las infecciones bacterianas odontogénicas. Medicina Oral, Patología Oral y Cirugía Bucal, v.9 n.5, Valencia nov-dic, 2004.




2020     |     www.medigraphic.com