2012, Number 1
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Rev Mex Patol Clin Med Lab 2012; 59 (1)
Degenerative lesion in patients operated for disc pathology. A histological study
Morales PV, Somonte ZDE, Expósito PE
Language: Spanish
References: 57
Page: 8-15
PDF size: 97.60 Kb.
ABSTRACT
The degenerative vertebral disc process is considered as the origin of the degenerative disease and the disc hernia. This is a global health problem with a great repercussion on the biosocial and economic spheres. In Cuba, the aforementioned problem is ranked among the first diseases affecting the locomotor apparatus. An analytical transversal study was carried out at the «Amalia Simoni» Hospital. The study included forty cases with a clinical and imaging diagnosis which had been surgically operated for lumbar disk disease. In every case, the affected vertebral disc was removed with the objective of analyzing the performance of the degenerative changes in it. Age, gender and predominant disc pathology were related. The histopathological changes were identified. Besides, it was established the correspondence between the imaging diagnosis and the histopathological diagnosis. The age group where the disc disease prevailed was the group ranging from 31 to 40 years old, and the prevailing gender was male. The disc pathology, according to the imaging diagnosis, was disc hernia. The main histopathological changes were: decreased cell density, formation of cell groups, acidophilia loss of collagen, and pale-staining of the amorphous matrix. There was no correlation between the imaging diagnosis and the histopathological diagnosis in the cases which had been diagnosed with disc hernia.
REFERENCES
Brodke D. Non surgical Management of low back pain and lumbar disc degeneration instructional course lectures. Vol 54 ed. JAOOS; 2005.
Gibson INA. Cirugía para prolapso de discos lumbares. In: The Cochrane Library, Issue 1, Oxford: Update Software; 2006.
Deyo RA. Outcome measures for low back pain research a proposal for standardized use. Spine 2003.
Herrera R. Límite de la artrodesis lumbar. Futuro y limitaciones de las nuevas técnicas en traumatología y ortopedia. Reflexiones. Controversias. MAPFRE; 1998.
Hanley E. Lumbar arthrodesis for the treatment of back pain. JBJS 1999; 81 (5).
Battié MC, Videman T, Parent E. Lumbar disc degeneration: epidemiology and genetics influences. Spine 2004; 29:2679-90.
Anderson G. Introduction. JBJS 2006; 88-A (S-2).
Roberts S. Histology and patology of the human intervertebral disc. JBJS Vol. 2006; 88-A (S-2).
Burke G. Dolor de espalda. Barcelona: ELICIEN; 1969.
http://www.geerarquis.org/afecciocl degenerativa Lumbar html. 2006
Miller P. Defining strategies for improving the identification and management of osteoporosis in the primary care setting. Presented at the ASNR, Washington, DC, 2003.
Niwayama G. Intervertebral disk herniation: Cartilaginous. Radiology 1978; 126: 57-65.
Rothman S. Implications of terminology. Presented at the ASNR, Washington, DC, 2003.
Gondim J, Ramos F. Thoracic spinal cord compression at two levels due to ligamentum flavum calcification. Arq Neuropsiquiatr 1998; 56 (2) 312-316.
Battié M. Lumbar Disc Degeneration: Epidemiology and Genetics JBJS 2006; 88-A (S-2).
Boos N, Weissbach S. Classification of age-related changes in lumbar intervertebral discs. Spine 2003; 29: 2668-2676.
Ala-Kokko L. Genetic risk factors for lumbar disc disease. Ann Med 2003; 34: 42-47.
Battié MC, Gibbons LE. Occupational driving and lumbar disc degeneration: A case-control study. Lancet 2003; 360: 1369-1374.
Solovieva S, Lohiniva J. COL9A3 gene polymorphism and obesity in intervertebral disc degeneration of the lumbar spine: evidence of gene-environment interaction. Spine 2003; 27: 2691-2696.
Yu Sw, Sether LA, Ho PS et al. Tears of the annulus fibrosus: correlation between MR pathologic findings in cadavers. AJR Am J Radiol 1988: 9: 367-370.
Armando Felipe Morán. Rev Cub Med Mil 1998; 27 (2).
Yu J, Fairbank JC. The elasctic fibre network of the annulus fibrosus of the normal and scoliotic human intervertebral disc. Spine 2005; 30: 1815-1820.
Boos N, Weissbach S. Classification of age-related changes in lumbar intervertebral discs. Spine 2004; 27: 2631-2644.
Fernández D, Sosa J. Estudio epidemiológico de las lesiones vértebro-medulares ocasionadas por accidentes laborales. Rehabilitación 1993 26: 74-78.
Resnick D. Guidelines for the performance of fusion procedures for degenerative disease of the lumbar spine. 2005; 2: 658-661.
Tash R. Preoperative and postoperative neuroradiologic evaluation of lumbar disc herniation. Mt Sinai J Med 1991; 58 (2): 129-132.
Cha CW. Gene therapy applications for spine fusion. Spine 2003; 28: S74-78.
Dvorak J. The outcome of surgery for the lumbar disc herniation. Spine 2004; 13; (12): 1418-1417.
Salas RJH. Hernias discales lumbares. Revisión de 100 casos. Rev Serv Med FAR 1974; 9 (1): 163-172.
Álvarez CR. Hernia discal lumbar. En: Tratado de cirugía ortopédica y traumatología. Habana, Cuba: Editorial Pueblo y Educación; 1986; TII: 268-283.
Eliseiev VG. Histología. Moscú: MIR; 1985.
Cormack DH. Histología de Ham. 9a ed. México: HARLA 1988; 413-414.
Johnson WE. Cell cluster formation in degenerate lumbar intervertebral discs is associated with increased disc cell proliferation. Connect Tissue Res 2004; 42:197-207.
Roberts S, Caterson B. Matrix metalloproteinases and aggrecanase: their role in disorders of the human intervertebral disc. Spine 2005; 25: 3005-3013.
Oegema TR Jr. Fibronectin and its fragments increase with degeneration in the human intervertebral disc. Spine 2004; 25: 2742-2747.
Freemont AJ, Ross ER. Nerve growth factor expression and innervation of the painful intervertebral disc. J Pathol 2004; 197: 286-292.
Roberts S. TNF alpha-stimulated gene product (TSG-6) and its binding protein, lalphal, in the human intervertebral disc: New molecules for the disc. Eur Spine 2005; 14: 36-42.
Bibby SR. Cell viability in scoliotic disc in relation to disc deformity and nutrient levels. Spine 2004; 27: 2220-2228.
Johnson WE. Human intervertebral disc cell morphology and cytoeskeletal composition: A preliminary study of reginal variations in health and disease. J Anat 2003; 203: 605-612.
Eyre DR. Collagen polymorphisms of the intervertebral disc. Biochem Soc Trans 2005; 30: 844-848.
Heinegard D. Glycosylated matrix proteins. In: Royce PM, Steimann B (eds). Connective tissue and its heritable disorders: molecular, genetic, and medical aspects. 2nd ed. New York: Wiley-Liss; 2005. p. 271-291.
Eyre DR. Recent developments in cartilage research: matrix biology of the collagen II/IX/XI heterofibril network. Biochem Soc Trans 2004; 30: 893-899.
Önnerfjord P. Identification of tyrosine sulfation in extracellular leucine-rich repeat proteins using mass spectrometry. J Biol Chem 2004; 279: 26-33.
Wiberg C. Complexes of matrilin-1 and biglycan or decorin connect collagen VI microfibrils to both collagen II and aggrecan. J Biol Chem 2003; 278: 37698-37704.
Lorenzo P. Altered patterns and synthesis of extracellular matrix macromolecules in early osteoarthritis. Matrix Biol 2004; 23: 381-391.
Seki S. A functional SNP in CILP, encoding cartilage intermediate layer protein, is associated with susceptibility to lumbar disc disease. Nat Genet 2005; 37: 607-612.
Rannou F. Cyclic tensile stretch modulates proteoglycan production by intervertebral disc annulus fibrosus cells through production of nitrite oxide. J Cell Biochem 2003; 90: 148-157.
Woods A. Integrin modulation by bilateral association. J Biol Chem 2006; 275: 24233-24236.
Heathfield TF. Cleavage of fibromodulin in cartilage explants involves removal of the N-terminal tyrosine sulphate-rich region by proteolysis at a site that is sensitive to matrix metalloproteinase 13. J Biol Chem 2004; 279: 6286-62895.
Haughton VM. Intervertebral disc pathology. Presented at XLI Annual Meeting ASRN, Washington, DC, 2003.
Volger JB, Murphy WA. Bone marrow imaging. Radiology 2004; 168: 679-693.
Resnik D. Correlation between radiographical and functional outcome. J Neurosurg Spine 2005; 2: 658-661.
Fardon DF. Nomenclature and classification of lumbar disc pathology. Recommendation of the North American Spine Society of Spine Radiology, and American Society of Neuroradiology. Spine 2004; 26: E93-E113.
Rothman S. Implications of terminology, presented at the ASRN, Washington DC 2003.
Stadnik TW et al. Annular tears and disc herniation: prevalence and contrast enhancement on MR images in the absence of low back pain or sciatica. Radiology 1998; 206: 49-55.
Pérez A, Salinas P. Comparación entre electromiografía y mielografía lumbar en el tratamiento de lumbalgias. Rev Fac Med Univers Andes 2003; 9: 1-4.
Önnerfjord P, Heinegard D. The extracellular matrix and inflammation: fibromodulin activates the classical pathway of complement by directly binding C1q. J Biol Chem 2005; 280: 32301-32308.