medigraphic.com

2011, Number 4

<< Back Next >>

Arch Med Actual Trac Gen Inf 2011; 3 (4)

Neoplasia Intraepitelial Vulvar

Gay PE

Language: Spanish
References: 43
Page: 15-24
PDF size: 136.25 Kb.


ABSTRACT

The incidence of vulvar intraepithelial neoplasia (VIN) associated with human papillomavirus (HPV) is increasing worldwide. When considering only women with 50 years or less, it was observed that the incidence of VIN has increased 392%, while that of invasive carcinoma increased by only 157%, which was interpreted as a predictable consequence of neoplastic transformation NIV. The NIV was first described by Bowen in 1912, which reported large lesions, which extend laterally and histology associated with squamous cell carcinoma in situ. It was not until 1986 that recommended the use of terminology ISSVD VIN in place of the classification of 1976. According to the biological nature of the injury, the VIN can be divided into two groups, each has its own characteristics. Both are precursors New International Version squamous cell carcinoma of the vulva. No specific clinical signs or symptoms of VIN lesions, so the diagnosis is histological. Morphological and clinical evidence that the NIV has the potential of progression to invasive cancer and, more rarely, regression. Treatments that are effective and do not distort the normal anatomy is increasingly recognized. Only the quadrivalent vaccine is approved for protection against precancerous lesions and cancer of the vulva and vagina. In conclusion, treatment of VIN is based on a comprehensive understanding of the natural history of this disease and the need to control the symptoms


REFERENCES

  1. Sturgeon, SR, Brinton, LA, Devesa, SS et al. In situ and invasive vulvar cancer incidence trends (1973 to 1987). Am J Obstet Gynecol, 166 (5): 1482-1485, 1992.

  2. Jones, RW. Vulval intraepithelial neoplasia: current perspectives. Eur J Gynaecol Oncol, 22: 393-402, 2001.

  3. Jones RW, Rowan DM, Stewart AW. Vulvar intraepithelial neoplasia. Aspects of the natural history and outcome in 405 women. Obstet Gynecol 2005;106:1319-26.

  4. Sykes P, Smith N, McCormick P, Frizelle FA. High-grade vulval intraepithelial neoplasia (VIN 3): a retrospective analysis of patient characteristics, management, outcome and relationship to squamous cell carcinoma of the vulva 1989-1999. Aust N Z J Obstet Gynaecol. 2002;42(1):69-74.

  5. Joura EA, Lösch A, Haider-Angeler, MG, et al. Trends in vulvar neoplasia. Increasing incidence of vulvar intraepithelial neoplasia and squamous cell carcinoma of the vulva in young women. J Reprod Med. 2000;45(8):613-5.

  6. Fonseca-Moutinho JA. Neoplasia intra-epitelial vulvar: um problema atual. RBGO 2008; 30(8): 420-6.

  7. Holschneider CH. Vulvar intraepithelial neoplasia. Disponível em: http/www.uptodate.com/online/content/topic.do=3ftopicKey=3dgyne_onc/5090=26view=3dprint. Última atualização em abril 2010. Acesso em 15/01/2011.

  8. Hildesheim A, Han CL, Brinton LA, Kurman RJ, Schiller JT. Human 18. papillomavirus type 16 and risk of preinvasive and invasive vulvar cancer: results from a seroepidemiological case-control study. Obstet Gynecol. 1997;90(5):748-54.

  9. Madeleine MM, Daling JR, Carter JJ, Wipf GC, Schwartz SM, McKnight B, et al. Cofactors with human papillomavirus in a population-based study of vulvar cancer. J Natl Cancer Inst. 1997;89(20):1516-23.

  10. Campaner AB, Santos RE, Galvão MAL. Importância do tabagismo na carcinogênese do colo uterino. Femina 2007;35(11):713-717.

  11. Massad LS, Silverberg MJ, SPRINGER G. et al. Effect of antiretroviral therapy on the incidence of genital warts and vulvar neoplasia among women with the human immunodeficiency virus. Am J Obstet Gynecol, 190 (5): 1241-1248, 2004.

  12. Duong TH, Flowers LC. Vulvo-vaginal cancers: risks, evaluation, prevention and early detection. Obstet Gynecol Clin North Am. 2007;34(4):783-802.

  13. Heller et al. Update on intraepithelial neoplasia of the vulva: proceedings of a Workshop at the 2009 World Congress of the International Society for the Study of Vulvovaginal Diseases, Edinburgh, Scotland, September 2009. J Low Genit Tract Dis. 2010 Oct;14(4):363-73.

  14. Ueda Y, Enomoto T, Kimura T, Yoshino K, Fujita M, Kimura T. Two distinct pathways to development of squamous cell carcinoma of the vulva. J Skin Cancer. 2011;2011:951250.

  15. Scurry J, Wilkinson EJ. Review of terminology of precursors of vulvar squamous cell carcinoma. J Low Genit Tract Dis. 2006;10(3):161-9.

  16. van de Nieuwenhof HP, Massuger LF, van der Avoort IA, Bekkers RL, Casparie M, Abma W, van Kempen LC, de Hullu JA. Vulvar squamous cell carcinoma development after diagnosis of VIN increases with age. Eur J Cancer. 2009;45(5):851-6.

  17. Blanc B, Benmoura D, D´Ercole C. Diagnostic and therapeutic approach of VIN3 among young woman. In: MONSONEGO, J. Challenges of Modern Medicine Volume 9: Papillomavirus in Human Pathology. Roma: Ares-Serono Symposia Publications, 1995, p. 413-418.

  18. Modesitt SC, Waters AB, Walton,L et al. Vulvar intraepithelial neoplasia III: occult cancer and the impact of margin status on recurrence. Obstet Gynecol, 92 (6): 962-966, 1998.

  19. Husseinzadeh N, Recinto C. Frequency of invasive cancer in surgically excised vulvar lesions with intraepithelial neoplasia (VIN 3). Gynecol Oncol, 73 (1): 119-120, 1999.

  20. Smith JS, Backes DM, Hoots BE, et al. Human papillomavirus type-distribution in vulvar and vaginal cancers and their associated precursors. Obstet Gynecol. 2009;113(4):917-24.

  21. Garland SM, Insinga RP, Sings HL, Haupt RM, Joura EA. Human papillomavirus infections and vulvar disease development. Cancer Epidemiol Biomarkers Prev. 2009;18(6):1777-84.

  22. van Seters M, van Beurden M, de Craen AJ. Is the assumed natural history of vulvar intraepithelial neoplasia III based on enough evidence? A systematic review of 3322 published patients. Gynecol Oncol. 2005;97(2):645-51.

  23. Jones WJ, Rowan DM. Spontaneous regression of vulvar intraepithelial neoplasia 2-3. Obstet Gynecol, 96 (3): 470-472, 2000.

  24. Kaufman RH. Intraepithelial neoplasia of the vulva. Gynecol Oncol, 56 (1): 8-21, 1995.

  25. Wright VC, Davies E. Laser surgery for vulvar intraepithelial neoplasia: principles and results. Am J Obstet Gynecol, 156 (2): 374-378, 1987.

  26. Reid R, Elfont EA, Zirkin RM. et al. Superficial laser vulvectomy. II. The anatomic and biophysical principles permitting accurate control over the depth of dermal destruction with the carbon dioxide laser. Am J Obstet Gynecol, 152 (3): 261-271, 1985.

  27. Shatz P, Bergeron C, Wilkinson EJ, et al. Vulvar intraepithelial neoplasia and skin appendage involvement. Obstet Gynecol, 74 (5): 769-774, 1989.

  28. Jayne CJ, Kaufman RH. Treatment of vulvar intraepithelial neoplasia 2/3 with imiquimod. J Reprod Med, 47 (5): 395-398, 2002.

  29. Le T, Menard C, Hicks-Boucher W, Hopkins L, Weberpals J, Fung-Kee-Fung M. Final results of a phase 2 study using continuous 5% Imiquimod cream application in the primary treatment of high-grade vulva intraepithelial neoplasia. Gynecol Oncol. 2007;106(3):579-84.

  30. Mathiesen O, Buus SK, Cramers M.Topical imiquimod can reverse vulvar intraepithelial neoplasia: a randomised, double-blinded study. Gynecol Oncol. 2007 Nov;107(2):219-22.

  31. HAIDOPOULOS, D.; DIAKOMANOLIS, E.; RODOLAKIS, A. et al. Safety and efficacy of locally applied imiquimod cream 5% for the treatment of condylomata acuminata of the vulva. Arch Gynecol Obstet, 2003.

  32. Iavazzo C, Pitsouni E, Athanasiou S, Falagas ME. Imiquimod for treatment of vulvar and vaginal intraepithelial neoplasia. Int J Gynaecol Obstet. 2008;101(1):3-10.

  33. van Seters M, van Beurden M, ten Kate FJ, Beckmann I, Ewing PC, Eijkemans MJ, Kagie MJ, Meijer CJ, Aaronson NK, Kleinjan A, Heijmans-Antonissen C, Zijlstra FJ, Burger MP, Helmerhorst TJ. Treatment of vulvar intraepithelial neoplasia with topical imiquimod. N Engl J Med. 2008;358(14):1465-73.

  34. Diaz-Arrastia C, Arany I, Robazetti SC, et al. Clinical and molecular responses in high-grade intraepithelial neoplasia treated with topical imiquimod 5%. Clin Cancer Res, 7 (10): 3031-3033, 2001.

  35. Petrow W, Gerdsen R, Uerlich M, et al. Successful topical immunotherapy of bowenoid papulosis with imiquimod. Br J Dermatol, 145 (6): 1022-1023, 2001.

  36. Testa R, Marchitelli C, Secco G, et al. Tratamiento del VIN de alto grado con imiquimod. In: XI International Congress of Cervical Pathology and Colposcopy, 2002. Barcelona. Proceedings of the XI International Congress of Cervical Pathology and Colposcopy, 2002, p. 328-329.

  37. Richter ON, Petrow W, Waldermann E, et al. Bowenoid papulosis of the vulvaimmunotherapeutical approach with topical imiquimod. Archives of Gynecology and Obstetrics 2003. Acesso em: 23/Jan/2003.

  38. Travis LB, Weinberg JM, Krumholz BA. Successful treatment of vulvar intraepithelial neoplasia with topical imiquimod 5% cream in a lung transplanted patient. Acta Derm Venereol, 82 (6): 475-476, 2002.

  39. Redondo P, Lloret P. Topical imiquimod for Bowenoid papulosis in an HIVpositive woman. Acta Derm Venereol, 82 (3): 212-213, 2002.

  40. Mahto M, Nathan M, O'Mahony C. More than a decade on: review of the use of imiquimod in lower anogenital intraepithelial neoplasia. Int J STD AIDS. 2010;21(1):8-16.

  41. CDC. MMWR 59 (20), May 28, 2010. Disponível em http://www.cdc.gov/mmwr/pdf/wk/mm5920.pdf

  42. Olsson SE, Kjaer SK, Sigurdsson K, et al. Evaluation of quadrivalent HPV 6/11/16/18 vaccine efficacy against cervical and anogenital disease in subjects with serological evidence of prior vaccine type HPV infection. Hum Vaccin. 2009 Oct 14;5(10).

  43. Joura EA, Garland SM, Paavonen J, Ferris DG, Sings HL, James MK; for the FUTURE I and II Study Group. Impact of Gardasil® in women who have undergone definitive therapy. Abstract. Eurogin 2010; SS 4-3. Available from: http://www.eurogin.com/2010/EUROGIN2010_Abstracts.pd




2020     |     www.medigraphic.com