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2002, Number 6

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Cir Cir 2002; 70 (6)

T/NK type-cell centrofacial angiocentric lymphomas. Histopathologic considerations and some clinical considerations of 30 patients at the Mexican National Institute of Cancerology

Meneses-García A, Súchil-Bernal L, Garza-Salazar J, Gómez-González E

Language: Spanish
References: 39
Page: 410-416
PDF size: 88.99 Kb.


ABSTRACT

Introduction: Thirty patients with diagnosis of angiocentric centrofacial lymphoma were studied at the Instituto Nacional de Cancerología in Mexico City. Material and methods: At the Instituto Nacional de Cancerología in Mexico City, were analyzed clinical and histologic features of 30 patients with NK-type cell angiocentric centrofacial lymphomas. Among these features were included age, sex, primary tumor site, main symptoms, treatment, outcome, and histopathologic findings. Results: There was a male-to-female ratio of 1.7:1 with mean age of 40.6 years (range 18-67 years). The most frequent initial manifestation was in nasal cavity (56.6%) followed by palate (13.3%). Main symptoms included fever, nasal obstruction, and rhinorrea. Treatment was grouped into four categories as follows: four patients received chemotherapy, 11 patients received chemotherapy followed of radiotherapy, 10 patients were treated with radiotherapy, and chemotherapy, and five patients received only radiotherapy. Patients who additionally developed tuberculosis and AIDS had an aggressive treatment course. Average follow-up in these 30 patients was 40.6 months. Patients treated with radiotherapy followed by chemotherapy and patients who received only radiotherapy showed better response and survival. Discussion: Angiocentric centrofacial lymphoma of T/NK-type cells is an aggressive, quick progressive disease associated with EBV and more aggressive in immunocompromised patients, mainly in patients with AIDS and tuberculosis. The treatment scheme with best results consisted of patients receiving only or radiotherapy followed by chemotherapy.


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