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Medicina & Laboratorio

2011, Number 09-10

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Medicina & Laboratorio 2011; 17 (09-10)

Hepatitis C

Restrepo GJC, Toro MAI

Language: Spanish
References: 89
Page: 411-428
PDF size: 1769.71 Kb.


ABSTRACT

Hepatitis C is a disease caused by hepatitis C virus and is the leading cause of cirrhosis and liver transplantation in the Western world. It is estimated that 3% of the world population is infected with this virus. Most infections are asymptomatic or can manifest nonspecific symptoms like fatigue, nausea, myalgia and fever, which can make the initial diagnosis more difficult. In the progression of the disease to the chronic stage, several factors can participate, including viral, host and external factors. The finding of abnormal laboratory tests or signs of cirrhosis should make the clinician consider hepatitis C. For the diagnosis, there are serological and virological assays available; serological assays detect antibodies against the virus, while virological assays can detect the viral RNA. The wide variety of quasispecies and the virus variability have not allowed the synthesis of a vaccine that provides protection.


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