Escobar M, Villamil M, Ruiz O

Language: Spanish
References: 16
Page: 351-357
PDF size: 347.31 Kb.

ABSTRACT

Introduction: An early diagnosis of subclinical hypothyroidism and the discovery of antithyroid antibodies are really valuable in preventing severe thyroid diseases. Objectives: To determine the prevalence of antithyroid antibodies in young men and women with subclinical and clinical hypothyroidism, and to compare their frequency among both genders. Materials and methods: The case study enrolled 280 students between 18 and 30 years of age from the Antonio Nariño University in Bogotá. TSH and free T4 was determined by chemoluminescence in all participants of the study for the identification of possible clinical and subclinical hypothyroidism. All individuals with alterations in their thyroid function tests had also their antiperoxidase and antithyroglobulin antibodies assessed by microelisa. Results: A high prevalence of antiperoxidase and antithyroglobulin antithyroid antibodies was detected in young people who had hypothyroidism, and the prevalence of hypothyroidism in young people was 4,64%. No statistically significant difference was found between the prevalence in men and women. Conclusion: There was a high prevalence of antibodies in the study population of young people with subclinical hypothyroidism, which could suggest an autoimmune cause in our university population. It is also necessary to carry out other clinical trials which could allow the investigation of possible causes of hypothyroidism like post-infectious, toxic and environmental and also a possible association between this disease and other autoimmune conditions.

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