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Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatán

2011, Number 3

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Rev Biomed 2011; 22 (3)

Obesity and metabolic syndrome: impact on cardiovascular diseases

Contreras-Leal ÉA, Santiago-García J

Language: Spanish
References: 70
Page: 103-115
PDF size: 369.52 Kb.


ABSTRACT

Excessive caloric intake and a sedentary life style are factors that promote adipose tissue growth and obesity. Adipose tissue releases several bioactive molecules such as leptin, adiponectin, interleukin- 6 (IL-6), tumor necrosis factor-α (TNF-α) and plasminogen activator inhibitor-1 (PAI-I). Under the pathological conditions of obesity, the excess of dysfunctional adipose tissue alters the release and balance of these molecules; leptin, IL-6, and TNF-α are increased, whereas adiponectin decreases, leading to the development of the metabolic syndrome and cardiovascular diseases. In this article we review the main metabolic alterations derived from obesity, such as: dyslipidemia, oxidative stress, inflammation, diabetes, endothelial dysfunction, insulin resistance, risk factors that contribute to the development of atherosclerosis, myocardial infarction, and other cardiovascular diseases.


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