2002, Number 2
<< Back Next >>
Cir Cir 2002; 70 (2)
D. Dimer in Preeclampsia-Eclampsia
Bravo-Topete EG, Morales-Esquivel JG, Briones-Vega CG, Díaz Leon-Ponce M, Briones-Garduño JC
Language: Spanish
References: 14
Page: 98-101
PDF size: 70.82 Kb.
ABSTRACT
Introduction: Obstetric patients, especially those complicated with any pregnancy-relate illness such as preeclampsia, are exposed to fibrinolytic disturbances.
Objective: Validation of D dimer determination in test obstetric patients this at hospital.
Matherial and method: We designed a transversal comparative study including two groups of patients selected randomly. Study group (A) was made up of 36 patients in the intensive care unit (ICU), with a pregnancy of 24 or more weeks complicated with preeclampsia-eclampsia. The control group (B) was made up of 33 patients with a pregnancy of 24 or more weeks without a pregnancy-related illness who came to this institution. We included the fibronosticon test as a routine exam, so there were no ethical implications to justify the use of a consent letter.
Results: We calculated sensitivity, specificity, positive and negative predictive values, and odds ratio (OR). We also compared the most important clinical and hematologic variables between both groups. We demonstrated that patients with a complicated pregnancy show significant elevations in D dimer levels and significant differences in the other variables compared.
We validated the test for D dimer determination for obstetric patients in this hospital.
REFERENCES
Briones GJC, Díaz de León PM, Gómez BTE, Avila EF, Briones VCG, Urrutia TF. Protocolo de manejo en preeclampsia-eclampsia. Estudio comparativo. Cir Ciruj 1999;67:4-10.
Verduzco RL, González PE, Manffrini MF, López AB. Dímero D en las diferentes etapas de la toxemia del embarazo. Estudio piloto. Ginec Obstet Mex 1998;66:77-80.
Dekker GA, Sibai BM. Etiology and pathogenesis of preeclampsia. Current concepts. Am J Obstet Gynecol 1998;179:1359-75.
Espinosa MML. Coagulación intravascular diseminada. En: Díaz de León PM, Aristondo MG, Briones GJG, editores. Medicina crítica. México: Distribuidora y Editora Mexicana, S.A. de C.V.; 2001.p.211-21.
Bellart J, Gilabert R, Anglés A, Piera V, Mirallos R, Monasterio J, Cabero L. Tissue factor levels and high ratio of fibrinopeptide A: D- dimer as a measure of endothelial procoaquiant disorder in pre-eclampsia. Br J Obstet Gynaecol 1999;106:594-597.
Herrera GI, Pinacho VJL, Velís PR. Sensibilidad y especificidad del dímero D2 de la fibrina, en el diagnóstico de la coagulación intravascular diseminada. Rev Mex Pediatr 1999;66(4):146-149.
Johansen M, Redman CWD, Wilkins T, Sargent L. Trophoblast deportation in human pregnancy its relevance for preeclampsia. Placenta 1999;20:531-539.
Ahlawat S, Pati HP, Bhatla N, Fatima L, Mittla S. Plasma platelet aggregating factor and platelet aggregation studies in pre-eclampsia. Acta Obstet Gynecol Scand 1996;75:428-43l.
Saleh AA, Sottoms SF, Farag AM, Dombrowsky MP, Welch RA, Norman G, Mammen EF. Markers for endothelial injury, clotting and platelet activation in preeclampsia. Arch Gynecol Obstet 1992;251: 105-110.
Grisaru D, Zwang E, Peyser M, Lessing R, Joseph B, Amiram E. The procoagulant activity of red blood cells from patients with severe preeclampsia. Am J Obstet Gynecol 1997;177:1513-6.
Grunewald C. Biochemical prediction of pre-eclampsia. Acta Obstet Gynecol Scand 1997;76(Suppl 164):104-107.
De García VP, García-Cáceres E. Thrombocytopenia, hypertension and seizures in eclampsia. Int J Gynecol Obstet 1998;61:15-20.
Dashe JS, Ramin S, Cunningham M, Gary F. The long term consequences of thrombotic microangiopathy (thrombotic thrombocytopenic purpura and hemolytic uremic syndrome) in pregnancy. Obstet Gynecol 1998;91:662-8.
McCrae KR, Douglas BC. Thrombotic microangiopathy during pregnancy seminars in hematology 1997;34(2):148-158.