Román UG

Language: Spanish
References: 28
Page: 285-290
PDF size: 153.47 Kb.

ABSTRACT

Some methods have been used for detection of High Risk Human Papillomavirus DNA, specifically for screening of cervical carcinoma in women. Compare and understand the real utility of these methods has become very important for physicians in the dialy clinical practice, and research. This is a review of the literature about the DNA Hybrid Capture Test HC2, which is available in Costa Rica and pretend to compare this method with the others, and to evaluate its specificity and sensibility. The conclusion is as follows: HC2 is very useful detection method in women with ASCUS who need more diagnostic studies, and specially in women older than 30. But results could be susceptible to misunderstanding, because of the possibility of cross reactions with low risk virus, and is a fact that many infections by HPV are transient. The traditional histological test Papanicolau (PAP) is still the gold standard for detection of cervical lesions; DNA detection by HC2 could add useful information because of its high sensibility, and both tests give valuable data. But the low specificity of DNA HC 2 is a warning for not making unnecessary studies; the clue is to use the test in the individual context, to obtain a complete clinical study of each patient.

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