Morales MVMI

Language: Spanish
References: 17
Page: 129-133
PDF size: 455.61 Kb.

ABSTRACT

Because of the widespread functions of dendritic cells, the aim of this review is to update the knowledge on dendritic cells (DC), as potent antigenpresenting cells (APC) expressing class II major histocompatibility (MHC) antigen. The different types of DC are derived from a common bone marrow precursor. They differentiate and migrate to lymphoid and non-lymphoid tissues under the influence of diverse stimuli. After binding antigen in their periphery they move to the lymph node activating T cells. Depending on the microenvironment, dendritic cells express several surface markers and secrete cytokines such as IL-12, IL-1 and TNFa. DC play a role in the pathogenesis of autoimmune and viral diseases being relevant in AIDS. These cells also infiltrate human tumors where they could be involved in the induction of anti-tumor immune response. The immunostimulatory properties of DC are currently applied in DC-based therapies of melanoma and lymphoma patients.

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