González POG, Palma LM

Language: Spanish
References: 8
Page: 117-120
PDF size: 174.74 Kb.

ABSTRACT

Epilepsy is the cause of one of the most frequent neurological in human people. It´s control usually requires a lot of drugs. A majority of the patients that suffer epilepsy are frecuent in women in fertile age, that in case of pregnancy migth exposse the product of conception to the effect of the drugs.
The following review is based on information from diferent articles about the use of anticonvulsants in pregnancy, their potential teratogenics risks and obstetrical complications.

REFERENCES

1. Brodie MJ, Dichter MA. Antiepileptics Drugs. N Engl J Med. 1996; 334: 168-74.

2. Brodie MJ, Dichter MA. New Antiepileptics Drugs. N Engl J Med. 1996; 334: 1583-90.

3. Hernandez-Díaz S, Werler MM, Walker AM, Mitchel AA. Folic acid antagonists during pregnancy and the risk of birth defects. N Eng J Med. 2000; 343: 1608-14.

4. Holmes LB, Harvey EA et al. The teratogenicity of anticonvulsants drugs. N Engl J Med 2001; 344: 1132-38.

5. Koren G, Pastuszak A, Ito S. Drugs in pregnancy. N Engl J Med 1998; 338: 1128-35.

6. McBride WG. Thalidomide and congenital abnormalities. Lancet 1961; 2: 1358.

7. Nau H. Species differences in pharmacokinetics and drug teratogenesis. Environ Health Perspect. 1986; 70: 113-29.

8. Teratology Society Public Affairs Committee. FDA Clasification of drugs for teratogenic risk. Teratology. 1994; 49: 446-7.