medigraphic.com
ISSN 0188-9796 (Print)

2011, Number 2

<< Back Next >>

Rev Endocrinol Nutr 2011; 19 (2)

Acromegaly and well-differentiated thyroid carcinoma

Mendoza-Hernández FC, Segovia-Palomo A, Carrasco-Tobón G, Peralta-Calcáneo JA, Sánchez-Pedraza V, Arellano-Montaño SA

Language: Spanish
References: 10
Page: 83-86
PDF size: 66.24 Kb.


ABSTRACT

The presence of thyroid cancer has been reported in 4.8% of acromegalic patients. TSH is important in thyroid carcinoma pathogenesis; nevertheless there are more factors involved such as IGF-I, IGF-II, EGF, Erb-B2, hepatocyte growth factor (HGF)/SF, IR, IGF-IR, VEGF. We report two patients with acromegaly who were found to have thyroid nodules that turned out to be papillary carcinoma.


REFERENCES

  1. Renehan AG, Brennan BM. Acromegaly, growth hormone and cancer risk. Best Pract Res Clin Endocrinol Metab 2008; 22: 639-657.

  2. Baris D, Gridley G, Ron E, Weiderpass E, Mellemkjaer L, Ekbom A, Olsen JH, Baron JA, Fraumeni JF Jr. Acromegaly and cancer risk: A cohort study in Sweden and Denmark. Cancer Causes Control 2002; 13: 395-400.

  3. Vella V, Sciacca L, Pandini G, Mineo R, Squatrito S, Vigneri R, Belfiore A. The IGF system in thyroid cancer: new concepts. Mol Pathol 2001; 54: 121-125.

  4. Cheung NW, Boyages SC. The thyroid gland in acromegaly; an ultrasonographic study. Clin Endocrinol 1997; 46: 545-549.

  5. Miyakawa M, Saji M, Tsushima T, Wakai K, Shizume K. Thyroid volume and serum thyroglobulin levels in patients with acromegaly: correlation with plasma insulin-like growth factor I levels. J Clin Endocrinol Metab 1988; 697: 973-978.

  6. Kurimoto M, Fukuda I, Hizuka N, Takano K. The prevalence of benign and malignant tumors in patients with acromegaly at a single institute. Endocr J 2008; 55: 67-71.

  7. Völzke H, Friedrich N, Schipf S, Haring R, Lüdemann J, Nauck M, Dörr M, Brabant G, Wallaschofski H. Association between serum insulin-like growth factor-I levels and thyroid disorders in a population-based study. J Clin Endocrinol Metab 2007; 92: 4039-4045.

  8. Ruchala M, Skiba A, Gurgul E, Uruski P, Wasko R, Sowinski J. The occurrence of thyroid focal lesions and a need for fine needle aspiration biopsy in patients with acromegaly due to an increased risk of thyroid cancer. Neuro Endocrinol Lett 2009; 30: 382-386.

  9. Tita P, Ambrosio MR, Scollo C, Carta A, Gangemi P, Bondanelli M, Vigneri R, Uberti E, Pezzino V. High prevalence of differentiated thyroid carcinoma in acromegaly. Clin Endocrinol 2005; 63: 161-167.

  10. Gydee H, O´Neill T, Patel A, Bauer A, Tuttle M, Francis G. Differentiated thyroid carcinomas from children and adolescents express IGF-I and the IGF-I receptor (IGF-I-R). Cancers with the most intense IGF-I-R expression may be more aggressive. Pediatr Res 2004; 55: 709-715.




2020     |     www.medigraphic.com