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ISSN 0188-9796 (Print)

2000, Number 2

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Rev Endocrinol Nutr 2000; 8 (2)

Bone mass lost during climacterium (Study of 490 cases in the femoral neck)

Barreira ME, Delezé HM, Morales TJ

Language: Spanish
References: 70
Page: 43-47
PDF size: 210.03 Kb.


ABSTRACT

The main reason of the study was to evaluate menopause female patients, and their femoral neck’s mineral density, among 44-55 years of age. In a six months densitometry study were registered 490 cases in three different cities of the country. This were splitted up in three groups, the first group among 40-45 year old range, the second group among 46-50 year old range, and the third group from 51-55 year old range in none of the cases it was specifically investigated the presence or absence risk factors of osteoporosis. The study results revealed that the first group (40-45 years) encountered osteopenia in a 29.91% and osteoporosis in a 2.56%; on the second group (46-50 years) the osteopenia had an increment to 42% and the osteoporosis had also an increment to 6.8%. Finally the third group encountered an osteopenia increase of 6.7% in relation to the second group and 18.79% in relation to the first group (48.7%), and an osteoporosis increase of 9.95% in relation to the second group and 14.19% in relation to the first group (16.75%). We considered of great importance the evaluation of hip bone mass during the first menopause years; since one of every six women suffer from hip fractures, which it has been determined the worst and most devastating complication on this sickness.


REFERENCES

  1. Consensus Development Conference: Diagnosis, prophylaxis and treatment of osteoporosis. Am J Med 1993; 94: 646-650.

  2. Anonymous. Osteoporosis: review of the evidence for prevention, diagnosis and treatment and cost-effectiveness analysis: status report. Osteoporosis Int 1998: 8 (suppl 4)S1-S88.

  3. Poor G et al. Determinants of Reduced Survival Following Hip Fractures in Men. Clin Orthop 1995; 319: 260-65.

  4. Kanis JA, Johnell O. The burden of osteoporosis. J Endocrinol Invest 1999; 22: 583-588.

  5. Riggs BL, Wahner WH, Dunn WL, Mazess RB, Offord KP, Melton U III. Differencial changes in bone mineral density of the appendicular and axial skeleton with aging.

  6. Relationship with to spinal osteoporosis. J Clin Invest 1981; 67: 328-335.

  7. Hansen MA, Overgaard K, Riis BJ, Christiansen C. Role of peak bone mass and bone loss in postmenopausal osteoporosis: 12 year study. Br Med J 1991; 303: 961-964.

  8. Delmas PD. Hormone replacement therapy in the prevention and treatment of osteoporosis. Osteoporosis Int 1997; Suppl 1: 5357.

  9. Riggs BL, Wahner WH, Seeman E, Offord KP, Dunn WL, Mazess RB, Johnson KA, Melton U III. Changes in bone mineral density of the proximal femur and spine whith aging. J Clin Invest 1982; 70: 716-723.

  10. Riggs BL, Wahner WH, Melton U III, Richelson LS, Judd L, Offord KP. Rates of bone loss in the appendicular and axial skeletons of women: Evidence of substantial vertebral bone loss before menopause. J Clin Invest 1986; 77: 1487-1491.

  11. Hui SL, Slemenda CW, Johnston CC, Appledorm CR. Effects of age and menopause on vertebral bone density. Bone Miner 1987; 2: 141-146 .

  12. Saambrook PN, Eisman JA, Furler SM, Pocock NA. Computer modeling and analysis of cross-sectional bone density studies with respect to age and the menopause. J Bone Miner Res 1987; 2: 119-114.

  13. Nilas L, Gotfresen A, Hadberg A, Christiansen C. Age related bone loss in women evaluated by single and dual photon technique. Bone Miner 1988; 4: 95-103.

  14. Hedlund LR, Gallagher JC. The effect of age and menopause on bone mineral density of the proximal femur. J Bone Miner Res 1989; 4: 639-642.

  15. Rodin A, Murby B, Smith MA, Caleffi M, Fentiman I, Chapman MG, Fogelman I. Premenopausal bone loss in the lumbar spine and neck of femur: A study of 225 caucasian women. Bone 1990; 11: 1-5.

  16. Sowers MB, Clark MK, Hollis B, Wallace RB, Jannausch M. Radial bone mineral density in pre and perimenopausal women. A prospective study of rates and risk factors for loss. J Bone Miner Res 1992; 7: 647-657.

  17. Hansen MA. Assessment of age and risk factors on bone density and bone turnover in healthy premenopausal women. Osteoporosis Int 1994; 4: 123-128.

  18. Christiansen C. Postmenopausal bone loss and the risk of osteoporosis. Osteoporosis Int 1994; 4(Suppl 1): S47-S51.

  19. Recker R, Lappe J, Kimmel D, Davies K. Longitudinal studies of perimenopausal bone loss. J Bone Miner Res 1995; 10: S147.

  20. Hansen MA, Overgaard K, Christiansen C. Spontaneous postmenopausal bone loss in different skeletal areas: Followed up for 15 years. J Bone Miner Res 1995; 10: 205-210.

  21. Garnero P, Sornay-Rendu E, Chapuy MC, Delmas PD. Increased bone turnover in late postmenopausal women is a major determinant of osteoporosis. J Bone Miner Res

  22. 1996; 11: 337-349.

  23. Kanis JA, Melton U, Christiansen C, Johnston C. The diagnosis of osteoporosis. J Bone Min Res 1994; 9: 1137-1141.

  24. World Health Organization. Assessment of fracture risk and its application to screening of postmenopausal osteoporosis. WHO Technical Report Series 843, WHO Geneva, 1994.

  25. Genant HK, Gramp SG, Glüer CC, Faulker KG, Jergas M et al. Universal Standarization for Dual X-ray absorciometry: Patient and Phantom Cross-Calibration Results. J Bone Min Res 1994; 9(10): 1503-1514.

  26. Reid DM, Lanham SA, McDonald AG et al. Speed and comparability of three dual-energy X-ray absorpciometer (DXA) models. In: Overgaard K, Christiansen C (eds). Osteoporosis 1990; 2: 575-577.

  27. Lauritzen JB, Schwarz P, Lund B, McNair P. Changing incidence and residual lifetime risk of common osteoporosis-related fractures. Osteoporosis Int 1993; 3: 127-132.

  28. Cooper C. The crippling consequences of fractures and their impact on quality of life. Am J Med 1997; 103: 125-195.

  29. Meunier PJ. Evidence-based medicine and osteoporosis. A comparison of fracture risk reduction data from osteoporosis randomized trials. Int J Clin Pract 1999; 53: 122-129.

  30. Hoerger TJ et al. Healthcare use among US women aged 45 and older. Total costs and costs selected postmenopausal health risk. J Womens Health 1998; 8: 1077-1089.

  31. Kanis JA, Delmas P, Burckhardt et al. Guidelines for diagnosis and management for osteoporosis. The European Foundation for Osteoporosis and Bone Disease. Osteoporosis Int 1997; 7: 390-406.

  32. Jalovaara P, Virkkunen H. Quality of life after primary hemiarthroplasty for femoral neck fracture: 6-year followup of 185 patients. Acta Orthop Scand 1991; 62: 208-217.

  33. Allander E et al. Falls and hip fracture. A reasonable basis for prevention? Scand J Rheumatol 1996; 25(suppl 103): 49-52.

  34. Delezé M, Aguirre E, Villa A, Calva J, Cons F et al. The Prevalence of Osteoporosis and Osteopenia by DEXA in an Apparently Healthy Mexican population. A Multicenter Study. Arthritis Rheum 1997; (suppl)40: 9: S41.

  35. Delezé M, Aguirre E, Villa A, Calva J, Cons F et al. Prevalencia de osteopenia y osteoporosis en México. Estudio Multicéntrico. Rev Med Intern Mex 1997; 13: (suppl): 4.

  36. Arlot ME, Sonray-Rendu E, Garnero P, Vey-Marty B, Delmas PD. Apparent Pre and Postmenopausal bone loss evaluated by DXA at different skeletal sites in women: The OFELY cohort. J Bone Miner Res 1997; 12(4): 683-690.

  37. Consensus Development Conference: Diagnosis, prophylaxis and treatment of osteoporosis. Am J Med 1993; 94: 646-650.

  38. Anonymous. Osteoporosis: review of the evidence for prevention, diagnosis and treatment and cost-effectiveness analysis: status report. Osteoporosis Int 1998: 8 (suppl 4)S1-S88.

  39. Poor G et al. Determinants of Reduced Survival Following Hip Fractures in Men. Clin Orthop 1995; 319: 260-65.

  40. Kanis JA, Johnell O. The burden of osteoporosis. J Endocrinol Invest 1999; 22: 583-588.

  41. Riggs BL, Wahner WH, Dunn WL, Mazess RB, Offord KP, Melton U III. Differencial changes in bone mineral density of the appendicular and axial skeleton with aging. Relationship with to spinal osteoporosis. J Clin Invest 1981; 67: 328-335.

  42. Hansen MA, Overgaard K, Riis BJ, Christiansen C. Role of peak bone mass and bone loss in postmenopausal osteoporosis: 12 year study. Br Med J 1991; 303: 961-964.

  43. Delmas PD. Hormone replacement therapy in the prevention and treatment of osteoporosis. Osteoporosis Int 1997; Suppl 1: 5357.

  44. Riggs BL, Wahner WH, Seeman E, Offord KP, Dunn WL, Mazess RB, Johnson KA, Melton U III. Changes in bone mineral density of the proximal femur and spine whith aging. J Clin Invest 1982; 70: 716-723.

  45. Riggs BL, Wahner WH, Melton U III, Richelson LS, Judd L, Offord KP. Rates of bone loss in the appendicular and axial skeletons of women: Evidence of substantial vertebral bone loss before menopause. J Clin Invest 1986; 77: 1487-1491.

  46. Hui SL, Slemenda CW, Johnston CC, Appledorm CR. Effects of age and menopause on vertebral bone density. Bone Miner 1987; 2: 141-146 .

  47. Saambrook PN, Eisman JA, Furler SM, Pocock NA. Computer modeling and analysis of cross-sectional bone density studies with respect to age and the menopause. J Bone Miner Res 1987; 2: 119-114.

  48. Nilas L, Gotfresen A, Hadberg A, Christiansen C. Age related bone loss in women evaluated by single and dual photon technique. Bone Miner 1988; 4: 95-103.

  49. Hedlund LR, Gallagher JC. The effect of age and menopause on bone mineral density of the proximal femur. J Bone Miner Res 1989; 4: 639-642.

  50. Rodin A, Murby B, Smith MA, Caleffi M, Fentiman I, Chapman MG, Fogelman I. Premenopausal bone loss in the lumbar spine and neck of femur: A study of 225 caucasian women. Bone 1990; 11: 1-5.

  51. Sowers MB, Clark MK, Hollis B, Wallace RB, Jannausch M. Radial bone mineral density in pre and perimenopausal women. A prospective study of rates and risk factors for loss. J Bone Miner Res 1992; 7: 647-657.

  52. Hansen MA. Assessment of age and risk factors on bone density and bone turnover in healthy premenopausal women. Osteoporosis Int 1994; 4: 123-128.

  53. Christiansen C. Postmenopausal bone loss and the risk of osteoporosis. Osteoporosis Int 1994; 4(Suppl 1): S47-S51.

  54. Recker R, Lappe J, Kimmel D, Davies K. Longitudinal studies of perimenopausal bone loss. J Bone Miner Res 1995; 10: S147.

  55. Hansen MA, Overgaard K, Christiansen C. Spontaneous postmenopausal bone loss in different skeletal areas: Followed up for 15 years. J Bone Miner Res 1995; 10: 205-210.

  56. Garnero P, Sornay-Rendu E, Chapuy MC, Delmas PD. Increased bone turnover in late postmenopausal women is a major determinant of osteoporosis. J Bone Miner Res 1996; 11: 337-349.

  57. Kanis JA, Melton U, Christiansen C, Johnston C. The diagnosis of osteoporosis. J Bone Min Res 1994; 9: 1137-1141.

  58. World Health Organization. Assessment of fracture risk and its application to screening of postmenopausal osteoporosis. WHO Technical Report Series 843, WHO Geneva, 1994.

  59. Genant HK, Gramp SG, Glüer CC, Faulker KG, Jergas M et al. Universal Standarization for Dual X-ray absorciometry: Patient and Phantom Cross-Calibration Results. J Bone Min Res 1994; 9(10): 1503-1514.

  60. Reid DM, Lanham SA, McDonald AG et al. Speed and comparability of three dual-energy X-ray absorpciometer (DXA) models. In: Overgaard K, Christiansen C (eds). Osteoporosis 1990; 2: 575-577.

  61. Lauritzen JB, Schwarz P, Lund B, McNair P. Changing incidence and residual lifetime risk of common osteoporosis-related fractures. Osteoporosis Int 1993; 3: 127-132.

  62. Cooper C. The crippling consequences of fractures and their impact on quality of life. Am J Med 1997; 103: 125-195.

  63. Meunier PJ. Evidence-based medicine and osteoporosis. A comparison of fracture risk reduction data from osteoporosis randomized trials. Int J Clin Pract 1999; 53: 122-129.

  64. Hoerger TJ et al. Healthcare use among US women aged 45 and older. Total costs and costs selected postmenopausal health risk. J Womens Health 1998; 8: 1077-1089.

  65. Kanis JA, Delmas P, Burckhardt et al. Guidelines for diagnosis and management for osteoporosis. The European Foundation for Osteoporosis and Bone Disease. Osteoporosis Int 1997; 7: 390-406.

  66. Jalovaara P, Virkkunen H. Quality of life after primary hemiarthroplasty for femoral neck fracture: 6-year followup of 185 patients. Acta Orthop Scand 1991; 62: 208-217.

  67. Allander E et al. Falls and hip fracture. A reasonable basis for prevention? Scand J Rheumatol 1996; 25(suppl 103): 49-52.

  68. Delezé M, Aguirre E, Villa A, Calva J, Cons F et al. The Prevalence of Osteoporosis and Osteopenia by DEXA in an Apparently Healthy Mexican population. A Multicenter Study. Arthritis Rheum 1997; (suppl)40: 9: S41.

  69. Delezé M, Aguirre E, Villa A, Calva J, Cons F et al. Prevalencia de osteopenia y osteoporosis en México. Estudio Multicéntrico. Rev Med Intern Mex 1997; 13: (suppl): 4.

  70. Arlot ME, Sonray-Rendu E, Garnero P, Vey-Marty B, Delmas PD. Apparent Pre and Postmenopausal bone loss evaluated by DXA at different skeletal sites in women: The OFELY cohort. J Bone Miner Res 1997; 12(4): 683-690.




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