García-Frade RLF, Villanueva SE, Peláez PJC

Language: Spanish
References: 12
Page: 314-319
PDF size: 406.20 Kb.

ABSTRACT

Background: We present the case of a patient being given anti-hypertensive treatment for 3 months and with a daily 100 mg dosage of acetylsalicylic acid who began showing symptoms 3 weeks prior to the examination with muscular pain, arthralgia and chills, followed by abdominal distension and pain in the right side with irradiation to the left infraescapular region. After the original exam in the emergency room an abdominal ultrasound and tomography showed the presence of hematoma in the left lobe of the liver. Not having shown record of previous trauma, a bleeding time test using the Ivy method was performed with a result of 11 minutes and an altered aggregometry slope. A 24 hour desmopressin infusion was used to correct the bleeding time test. A magnetic resonance corroborated the presence of hepatic hematoma. Drainage by laparoscopic surgery is performed and in 7 days time the patient is released.
Discussion: no reports were found about the relationship of hepatic hematoma and the use of platelet drugs.
Conclusion: it is possible that the presence of atypical manifestations of bleeding after the consumption of platelet drugs is from multifactor phenomena like: high dosage; pharmacological, nutritional or herbal interactions; non-perceivable trauma; or an elevated response to the effect of the acetylsalicylic acid with different genetic polymorphisms.

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