Río PAF, González LJA, Valdés DMA, Guerrero DFI

Language: Spanish
References: 13
Page: 310-313
PDF size: 337.09 Kb.

ABSTRACT

Acute promyelocytic leukemia (APL) is now the most curable subtype of acute myeloid leukemia in adults. The incidence is less 10%, is common the t (15;17) translocation. The incorporation of transretinoic acid (ATRA) in induction results in a high complete remission rate, leads to a rapid resolution of characteristic life-threatening coagulopathy, and most importantly, decreases the relapse rate compared with treatment with chemotherapy alone. It is usually well tolerated but may have side effects, of which the most severe ATRA syndrome is potentially fatal. The manifestations are fever, weight gain, pulmonary infiltrates, respiratory distress, pleural or pericardial effusion, hypotension, liver and kidney failure. The treatment is based on suspension of the ATRA, support measures and high doses of steroids.

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