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Colegio de Medicina Interna de México.

2011, Number 3

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Med Int Mex 2011; 27 (3)

Cognitive function in patients with type 2 diabetes mellitus: metabolic correlation and magnetic resonance imaging

Cervantes-Arriaga A, Rodríguez-Violante M, Calleja-Castillo J, Ramírez-Bermudez J

Language: Spanish
References: 28
Page: 217-223
PDF size: 357.24 Kb.


ABSTRACT

Background: Cognitive impairment is common in patients with type 2 diabetes mellitus and its etiology is still not precisely known since there are multiple factors involved.
Material and Methods: We conducted a cross sectional study including subjects over 40 years old with established diagnosis of type 2 diabetes mellitus and with at least one year of duration, who attended the outpatient internal medicine clinic. A neuropsychological evaluation, metabolic study and an MRI brain scan was performed.
Results: We analyzed 51 patients with diabetes mellitus. No significant correlation was found between metabolic factors and the cognitive function in subjects with type 2 diabetes mellitus. However, differences were found in the score of neuropsychological instruments in relation to the presence or absence of small vessel disease on the magnetic resonance imaging scan (p = 0.01). An association was found between the presence of dyslipidemia and small vessel disease in patients with diabetes mellitus (p=0.02).
Conclusions: No correlation between metabolic factors and cognitive function in subjects with type 2 diabetes mellitus was found. On the other hand, an assosciation between the presence of dyslipidemia and small vessel disease was found in diabetic patients with cognitive impairment which suggests a macrovascular mechanism.


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