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ISSN 2992-8559 (Electronic)
ISSN 1405-0625 (Print)

1999, Number 2

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Cir Plast 1999; 9 (2)

Vasodilator comparative effect between pargeverine chlorhidrate and 2% simple lidocaine in rat carotide artery

Cerda-Mendoza RC, Romero-Zárate JL, Pastrana-Figueroa JM, Álvarez-Díaz CJ

Language: Spanish
References: 16
Page: 64-70
PDF size: 359.47 Kb.


ABSTRACT

The possibility of microsurgical tissue transfer yielding 100% success is not yet possible because of factors such as the secondary vascular spasm that brings about a circulatory flow reduction, thrombosis and transfer flaw. In this study the vasodilator effect of pargeverine chlorhidrate compared to 2% simple lidocaine controlled with a saline solution is determined, in 20 Fisher 344 rats that were divided in two groups, with a carotide basal measurement by a milimetrical acetate and a surgical microscope with an optical milimetrical measure lense, both carotides section producing pharmacologic vasospasm with 1:200,000 epinephrine. In group A saline solution was used in one artery and simple lidocaine in the other and in group B, saline solution on one side and pargeverine chlorhidrate in the other. Carotides diameter was measured before and after these substances local application was carried out, from 1.1 to 1.4 mm basal; from 1.0 to 1.2 mm, with epinephrine; from 1.0 to 1.3 mm, with saline solution; from 1.0 to 1.3 mm with 2% simple lidocaine, and 1.2 to 1.5 mm with pargeverine chlorhidrate (p ⁦ 0.00022). We concluded that pargeverine chlorhidrate had a greater vasodilation than the 2% simple lidocaine and saline solution, once the vasospasm produced pharmacological and surgical action was broken with a greater vasodilation than the basal diameter. With these findings, the possibility of clinical use in microsurgery is open.


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